Selectins
The selectins are three related receptors that initiate rolling of leukocytes on activated platelets or endothelium through Ca 2+-dependent recognition of cell surface carbohydrates. Cell adhesion may be enhanced by a limited number of membrane glycoproteins that present high affinity carbohydrate l...
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| Veröffentlicht in: | Current opinion in immunology 1994-02, Vol.6 (1), p.75-84 |
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| container_title | Current opinion in immunology |
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| creator | McEver, Rodger P. |
| description | The selectins are three related receptors that initiate rolling of leukocytes on activated platelets or endothelium through Ca
2+-dependent recognition of cell surface carbohydrates. Cell adhesion may be enhanced by a limited number of membrane glycoproteins that present high affinity carbohydrate ligands to specific selectins. The synthesis and surface display of the selectins is normally tightly controlled, but inappropriate expression may contribute to inflammatory disorders. Recent
in vivo studies confirm the importance of the selectins in both physiological and pathological leukocyte recruitment. |
| doi_str_mv | 10.1016/0952-7915(94)90037-X |
| format | Article |
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2+-dependent recognition of cell surface carbohydrates. Cell adhesion may be enhanced by a limited number of membrane glycoproteins that present high affinity carbohydrate ligands to specific selectins. The synthesis and surface display of the selectins is normally tightly controlled, but inappropriate expression may contribute to inflammatory disorders. Recent
in vivo studies confirm the importance of the selectins in both physiological and pathological leukocyte recruitment.</description><identifier>ISSN: 0952-7915</identifier><identifier>EISSN: 1879-0372</identifier><identifier>DOI: 10.1016/0952-7915(94)90037-X</identifier><identifier>PMID: 7513527</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Carbohydrate Sequence ; Cell Adhesion Molecules - genetics ; Cell Adhesion Molecules - immunology ; Cell Adhesion Molecules - physiology ; E-Selectin ; Gene Expression Regulation ; Humans ; L-Selectin ; Ligands ; Molecular Sequence Data ; P-Selectin ; Platelet Membrane Glycoproteins - genetics ; Platelet Membrane Glycoproteins - immunology ; Platelet Membrane Glycoproteins - physiology ; Receptors, Immunologic - physiology ; Signal Transduction - physiology</subject><ispartof>Current opinion in immunology, 1994-02, Vol.6 (1), p.75-84</ispartof><rights>1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-90346ec9e42c005dc96f7b39e37174988ee3d223b9c3ed0ecdf8f5703eb5061c3</citedby><cites>FETCH-LOGICAL-c388t-90346ec9e42c005dc96f7b39e37174988ee3d223b9c3ed0ecdf8f5703eb5061c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/095279159490037X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7513527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McEver, Rodger P.</creatorcontrib><title>Selectins</title><title>Current opinion in immunology</title><addtitle>Curr Opin Immunol</addtitle><description>The selectins are three related receptors that initiate rolling of leukocytes on activated platelets or endothelium through Ca
2+-dependent recognition of cell surface carbohydrates. Cell adhesion may be enhanced by a limited number of membrane glycoproteins that present high affinity carbohydrate ligands to specific selectins. The synthesis and surface display of the selectins is normally tightly controlled, but inappropriate expression may contribute to inflammatory disorders. Recent
in vivo studies confirm the importance of the selectins in both physiological and pathological leukocyte recruitment.</description><subject>Animals</subject><subject>Carbohydrate Sequence</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Cell Adhesion Molecules - immunology</subject><subject>Cell Adhesion Molecules - physiology</subject><subject>E-Selectin</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>L-Selectin</subject><subject>Ligands</subject><subject>Molecular Sequence Data</subject><subject>P-Selectin</subject><subject>Platelet Membrane Glycoproteins - genetics</subject><subject>Platelet Membrane Glycoproteins - immunology</subject><subject>Platelet Membrane Glycoproteins - physiology</subject><subject>Receptors, Immunologic - physiology</subject><subject>Signal Transduction - physiology</subject><issn>0952-7915</issn><issn>1879-0372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoModa3-A72KHlYnO_m8CFL8goIHFXoL3WQWItuuJq3gv3fXlh71NAzzvO_Aw9gphysOXF2DlVWpLZcXVlxaANTlbI8V3Ghb9ku1z4odcsiOcn4HACkRRmykJUdZ6YIVL9SSX8VlPmYHzbzNdLKdY_Z2f_c6eSynzw9Pk9tp6dGYVWkBhSJvSVS-rwveqkbXaAk118IaQ4ShqrC2HikA-dCYRmpAqiUo7nHMzje9H6n7XFNeuUXMntp2vqRunZ1WQnMp8F-QK6OMwQEUG9CnLudEjftIcTFP346DG1S5wYMbPDgr3K8qN-tjZ9v-db2gsAtt3fT3m82dehtfkZLLPtLSU4ipV-ZCF_9-8AOS5XV7</recordid><startdate>19940201</startdate><enddate>19940201</enddate><creator>McEver, Rodger P.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19940201</creationdate><title>Selectins</title><author>McEver, Rodger P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-90346ec9e42c005dc96f7b39e37174988ee3d223b9c3ed0ecdf8f5703eb5061c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Carbohydrate Sequence</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Cell Adhesion Molecules - immunology</topic><topic>Cell Adhesion Molecules - physiology</topic><topic>E-Selectin</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>L-Selectin</topic><topic>Ligands</topic><topic>Molecular Sequence Data</topic><topic>P-Selectin</topic><topic>Platelet Membrane Glycoproteins - genetics</topic><topic>Platelet Membrane Glycoproteins - immunology</topic><topic>Platelet Membrane Glycoproteins - physiology</topic><topic>Receptors, Immunologic - physiology</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McEver, Rodger P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McEver, Rodger P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selectins</atitle><jtitle>Current opinion in immunology</jtitle><addtitle>Curr Opin Immunol</addtitle><date>1994-02-01</date><risdate>1994</risdate><volume>6</volume><issue>1</issue><spage>75</spage><epage>84</epage><pages>75-84</pages><issn>0952-7915</issn><eissn>1879-0372</eissn><abstract>The selectins are three related receptors that initiate rolling of leukocytes on activated platelets or endothelium through Ca
2+-dependent recognition of cell surface carbohydrates. Cell adhesion may be enhanced by a limited number of membrane glycoproteins that present high affinity carbohydrate ligands to specific selectins. The synthesis and surface display of the selectins is normally tightly controlled, but inappropriate expression may contribute to inflammatory disorders. Recent
in vivo studies confirm the importance of the selectins in both physiological and pathological leukocyte recruitment.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>7513527</pmid><doi>10.1016/0952-7915(94)90037-X</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0952-7915 |
| ispartof | Current opinion in immunology, 1994-02, Vol.6 (1), p.75-84 |
| issn | 0952-7915 1879-0372 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76471543 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Carbohydrate Sequence Cell Adhesion Molecules - genetics Cell Adhesion Molecules - immunology Cell Adhesion Molecules - physiology E-Selectin Gene Expression Regulation Humans L-Selectin Ligands Molecular Sequence Data P-Selectin Platelet Membrane Glycoproteins - genetics Platelet Membrane Glycoproteins - immunology Platelet Membrane Glycoproteins - physiology Receptors, Immunologic - physiology Signal Transduction - physiology |
| title | Selectins |
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