Compartmental Modeling of Iodine-123-Iodobenzofuran Binding to Dopamine D2 Receptors in Healthy Subjects

Iodine-123-labeled iodobenzofuran ([123I]IBF) is a potent dopamine D2 antagonist that provides good visualization of D2 receptors in primates. The feasibility of measuring dopamine D2 binding potential with [123I]IBF in humans was evaluated in eight healthy subjects. Following [123I]IBF injection (6...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 1994-05, Vol.35 (5), p.743-754
Hauptverfasser:	Laruelle, Marc, van Dyck, Chris, Abi-Dargham, Anissa, Zea-Ponce, Yolanda, Zoghbi, Sami S, Charney, Dennis S, Baldwin, Ronald M, Hoffer, Paul B, Kung, Hank F, Innis, Robert B
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Sprache:	eng
Schlagworte:	Adult Benzofurans Brain - metabolism Data Interpretation, Statistical Feasibility Studies Female Humans Iodine Radioisotopes Male Models, Biological Pyrrolidines Receptors, Dopamine D2 - metabolism Tomography, Emission-Computed, Single-Photon
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container_title	The Journal of nuclear medicine (1978)
container_volume	35
creator	Laruelle, Marc van Dyck, Chris Abi-Dargham, Anissa Zea-Ponce, Yolanda Zoghbi, Sami S Charney, Dennis S Baldwin, Ronald M Hoffer, Paul B Kung, Hank F Innis, Robert B
description	Iodine-123-labeled iodobenzofuran ([123I]IBF) is a potent dopamine D2 antagonist that provides good visualization of D2 receptors in primates. The feasibility of measuring dopamine D2 binding potential with [123I]IBF in humans was evaluated in eight healthy subjects. Following [123I]IBF injection (6 mCi), scans were acquired every 10 min for 160 min with the brain-dedicated CERASPECT camera. Arterial activities were obtained at various intervals and corrected for the presence of metabolites by extraction followed by reverse-phase high-performance liquid chromatography. Reconstructed images exhibited adequate basal ganglia-to-occipital ratios (from 1.96 +/- 0.34 at 30 min to 3.54 +/- 0.71 at 150 min, mean +/- s.d.). Time-activity curves demonstrated reversibility, with peak basal ganglia uptake at 50 +/- 25 min. Regional time-activity curves were analyzed with kinetic three-compartment modeling and graphic analysis. In all subjects, D2 binding potential values, as derived by both methods, were in excellent agreement (mean +/- s.d. D2 binding potential = 129 +/- 51). An empiric count ratio method that does not require measurement of arterial tracer concentrations was evaluated and found to be in reasonable agreement with the model-derived binding potential. Iodine-131-IBF is a suitable ligand for quantitative studies of D2 receptor density with SPECT in humans.
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The feasibility of measuring dopamine D2 binding potential with [123I]IBF in humans was evaluated in eight healthy subjects. Following [123I]IBF injection (6 mCi), scans were acquired every 10 min for 160 min with the brain-dedicated CERASPECT camera. Arterial activities were obtained at various intervals and corrected for the presence of metabolites by extraction followed by reverse-phase high-performance liquid chromatography. Reconstructed images exhibited adequate basal ganglia-to-occipital ratios (from 1.96 +/- 0.34 at 30 min to 3.54 +/- 0.71 at 150 min, mean +/- s.d.). Time-activity curves demonstrated reversibility, with peak basal ganglia uptake at 50 +/- 25 min. Regional time-activity curves were analyzed with kinetic three-compartment modeling and graphic analysis. In all subjects, D2 binding potential values, as derived by both methods, were in excellent agreement (mean +/- s.d. D2 binding potential = 129 +/- 51). An empiric count ratio method that does not require measurement of arterial tracer concentrations was evaluated and found to be in reasonable agreement with the model-derived binding potential. 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The feasibility of measuring dopamine D2 binding potential with [123I]IBF in humans was evaluated in eight healthy subjects. Following [123I]IBF injection (6 mCi), scans were acquired every 10 min for 160 min with the brain-dedicated CERASPECT camera. Arterial activities were obtained at various intervals and corrected for the presence of metabolites by extraction followed by reverse-phase high-performance liquid chromatography. Reconstructed images exhibited adequate basal ganglia-to-occipital ratios (from 1.96 +/- 0.34 at 30 min to 3.54 +/- 0.71 at 150 min, mean +/- s.d.). Time-activity curves demonstrated reversibility, with peak basal ganglia uptake at 50 +/- 25 min. Regional time-activity curves were analyzed with kinetic three-compartment modeling and graphic analysis. In all subjects, D2 binding potential values, as derived by both methods, were in excellent agreement (mean +/- s.d. D2 binding potential = 129 +/- 51). An empiric count ratio method that does not require measurement of arterial tracer concentrations was evaluated and found to be in reasonable agreement with the model-derived binding potential. Iodine-131-IBF is a suitable ligand for quantitative studies of D2 receptor density with SPECT in humans.</description><subject>Adult</subject><subject>Benzofurans</subject><subject>Brain - metabolism</subject><subject>Data Interpretation, Statistical</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Iodine Radioisotopes</subject><subject>Male</subject><subject>Models, Biological</subject><subject>Pyrrolidines</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF9LwzAUxYMoc04_gpAn3wJN0zTpo27qBhPBP88laW_XjDapSYrMT2-HAzkP9zz8ONxzztCccsYJz3NxjuYJzSnhPOGX6CqEfZIkuZRyhmaSijzj2Ry1S9cPyscebFQdfnE1dMbusGvwxtXGAqEpI5N1GuyPa0avLH4wtj5C0eGVG1Q_YXiV4jeoYIjOB2wsXoPqYnvA76PeQxXDNbpoVBfg5nQX6PPp8WO5JtvX583yfkvalIlItKJVzaXQOtHVJFEIqQuoGGRNljZKTI-rrFGN0LmYGkhGoVCc1TJnoGvOFujuL3fw7muEEMvehAq6TllwYyin3oLSgk3g7QkcdQ91OXjTK38oT9P8B7Vm134bD6Udqw6UP8J72zNe8lJkjP0C6ZVvNQ</recordid><startdate>19940501</startdate><enddate>19940501</enddate><creator>Laruelle, Marc</creator><creator>van Dyck, Chris</creator><creator>Abi-Dargham, Anissa</creator><creator>Zea-Ponce, Yolanda</creator><creator>Zoghbi, Sami S</creator><creator>Charney, Dennis S</creator><creator>Baldwin, Ronald M</creator><creator>Hoffer, Paul B</creator><creator>Kung, Hank F</creator><creator>Innis, Robert B</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19940501</creationdate><title>Compartmental Modeling of Iodine-123-Iodobenzofuran Binding to Dopamine D2 Receptors in Healthy Subjects</title><author>Laruelle, Marc ; van Dyck, Chris ; Abi-Dargham, Anissa ; Zea-Ponce, Yolanda ; Zoghbi, Sami S ; Charney, Dennis S ; Baldwin, Ronald M ; Hoffer, Paul B ; Kung, Hank F ; Innis, Robert B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h237t-ba1cd587bb0bcbcb7978b9ec3e4f42fa7176a4faf7b67454831e9a53d863ebd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Benzofurans</topic><topic>Brain - metabolism</topic><topic>Data Interpretation, Statistical</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Iodine Radioisotopes</topic><topic>Male</topic><topic>Models, Biological</topic><topic>Pyrrolidines</topic><topic>Receptors, Dopamine D2 - metabolism</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laruelle, Marc</creatorcontrib><creatorcontrib>van Dyck, Chris</creatorcontrib><creatorcontrib>Abi-Dargham, Anissa</creatorcontrib><creatorcontrib>Zea-Ponce, Yolanda</creatorcontrib><creatorcontrib>Zoghbi, Sami S</creatorcontrib><creatorcontrib>Charney, Dennis S</creatorcontrib><creatorcontrib>Baldwin, Ronald M</creatorcontrib><creatorcontrib>Hoffer, Paul B</creatorcontrib><creatorcontrib>Kung, Hank F</creatorcontrib><creatorcontrib>Innis, Robert B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laruelle, Marc</au><au>van Dyck, Chris</au><au>Abi-Dargham, Anissa</au><au>Zea-Ponce, Yolanda</au><au>Zoghbi, Sami S</au><au>Charney, Dennis S</au><au>Baldwin, Ronald M</au><au>Hoffer, Paul B</au><au>Kung, Hank F</au><au>Innis, Robert B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Compartmental Modeling of Iodine-123-Iodobenzofuran Binding to Dopamine D2 Receptors in Healthy Subjects</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1994-05-01</date><risdate>1994</risdate><volume>35</volume><issue>5</issue><spage>743</spage><epage>754</epage><pages>743-754</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>Iodine-123-labeled iodobenzofuran ([123I]IBF) is a potent dopamine D2 antagonist that provides good visualization of D2 receptors in primates. The feasibility of measuring dopamine D2 binding potential with [123I]IBF in humans was evaluated in eight healthy subjects. Following [123I]IBF injection (6 mCi), scans were acquired every 10 min for 160 min with the brain-dedicated CERASPECT camera. Arterial activities were obtained at various intervals and corrected for the presence of metabolites by extraction followed by reverse-phase high-performance liquid chromatography. Reconstructed images exhibited adequate basal ganglia-to-occipital ratios (from 1.96 +/- 0.34 at 30 min to 3.54 +/- 0.71 at 150 min, mean +/- s.d.). Time-activity curves demonstrated reversibility, with peak basal ganglia uptake at 50 +/- 25 min. Regional time-activity curves were analyzed with kinetic three-compartment modeling and graphic analysis. In all subjects, D2 binding potential values, as derived by both methods, were in excellent agreement (mean +/- s.d. D2 binding potential = 129 +/- 51). An empiric count ratio method that does not require measurement of arterial tracer concentrations was evaluated and found to be in reasonable agreement with the model-derived binding potential. Iodine-131-IBF is a suitable ligand for quantitative studies of D2 receptor density with SPECT in humans.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>8176454</pmid><tpages>12</tpages></addata></record>
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source	MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects	Adult Benzofurans Brain - metabolism Data Interpretation, Statistical Feasibility Studies Female Humans Iodine Radioisotopes Male Models, Biological Pyrrolidines Receptors, Dopamine D2 - metabolism Tomography, Emission-Computed, Single-Photon
title	Compartmental Modeling of Iodine-123-Iodobenzofuran Binding to Dopamine D2 Receptors in Healthy Subjects
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