Epigenetic regulation of the maize Spm transposable element: Novel activation of a methylated promoter by TnpA

Spm is epigenetically inactivated by C-methylation near its transcription start site. We have investigated the interaction between TnpA, an autoregulatory protein that can reactivate a silent Spm, and the promoter of the element. The promoter undergoes rapid de novo methylation and inactivation in s...

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Veröffentlicht in:	Cell 1994-05, Vol.77 (3), p.427-437
Hauptverfasser:	Schläppi, Michael, Raina, Ramesh, Fedoroff, Nina
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences DNA - metabolism DNA Transposable Elements - genetics DNA-Binding Proteins Fundamental and applied biological sciences. Psychology Genes, Plant - genetics Genic rearrangement. Recombination. Transposable element Methylation Models, Genetic Molecular and cellular biology Molecular genetics Molecular Sequence Data Plant Proteins - genetics Plant Proteins - metabolism Plants, Genetically Modified - cytology Plants, Genetically Modified - genetics Promoter Regions, Genetic - genetics Protein Binding Protein Conformation Repressor Proteins Sequence Deletion - genetics Transcription, Genetic Transcriptional Activation - genetics Zea mays Zea mays - genetics
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