Adenovirus-mediated gene transfer of soluble vascular cell adhesion molecule to porcine interposition vein grafts

The efficacy of aorto-coronary vein grafting is limited by early graft thrombosis and accelerated graft atherosclerosis. Direct adenovirus-mediated transfer of genes encoding inhibitory proteins may prevent or slow progression of vein graft disease. Recombinant adenoviruses containing the cDNA for t...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1994-05, Vol.89 (5), p.1922-1928
Hauptverfasser:	SHI-JEN CHEN, WILSON, J. M, MULLER, D. W. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Atherosclerosis (general aspects, experimental research) Base Sequence Biological and medical sciences Blood and lymphatic vessels Blood Vessel Prosthesis Cardiology. Vascular system Carotid Arteries - surgery Cell Adhesion Molecules - genetics Endothelium, Vascular - metabolism Fluorescent Antibody Technique Gene Expression Gene Transfer Techniques Genetic Vectors Graft Occlusion, Vascular - prevention & control Humans In Situ Hybridization Jugular Veins - transplantation Medical sciences Molecular Sequence Data Saphenous Vein - transplantation Swine Transfection Vascular Cell Adhesion Molecule-1
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