Effect of arginase on splenic killer cell activity in patients with gastric cancer
Arginase has been detected in high levels in gastric cancer tissues. The effect of arginase on the activities of splenic natural killer (NK) cell, phytohemagglutinin activated killer (PAK) cell, and interleukin-2 activated killer (LAK) cell in patients with gastric cancer (N = 12) was evaluated in v...
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| Veröffentlicht in: | Digestive diseases and sciences 1994-05, Vol.39 (5), p.1107-1112 |
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| container_issue | 5 |
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| container_title | Digestive diseases and sciences |
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| creator | Wu, C W Chi, C W Ho, C K Chien, S L Liu, W Y P'eng, F K Wang, S R |
| description | Arginase has been detected in high levels in gastric cancer tissues. The effect of arginase on the activities of splenic natural killer (NK) cell, phytohemagglutinin activated killer (PAK) cell, and interleukin-2 activated killer (LAK) cell in patients with gastric cancer (N = 12) was evaluated in vitro. These activities in patients (N = 10) with trauma and benign lesions were used as control. The splenic NK and PAK cell activities in patients with gastric cancer were significantly lower than in the controls (P < 0.05), whereas LAK cell activity did not have significant difference. Arginase inhibited all splenic killer cell activities to a similar degree between patients with gastric cancer and the controls. The inhibition was dose-related. These data suggest that arginase may play a positive role in the spread of gastric cancer cells. However, LAK may be a potential approach of immunoadoptive therapy in the future. |
| doi_str_mv | 10.1007/BF02087565 |
| format | Article |
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The effect of arginase on the activities of splenic natural killer (NK) cell, phytohemagglutinin activated killer (PAK) cell, and interleukin-2 activated killer (LAK) cell in patients with gastric cancer (N = 12) was evaluated in vitro. These activities in patients (N = 10) with trauma and benign lesions were used as control. The splenic NK and PAK cell activities in patients with gastric cancer were significantly lower than in the controls (P < 0.05), whereas LAK cell activity did not have significant difference. Arginase inhibited all splenic killer cell activities to a similar degree between patients with gastric cancer and the controls. The inhibition was dose-related. These data suggest that arginase may play a positive role in the spread of gastric cancer cells. However, LAK may be a potential approach of immunoadoptive therapy in the future.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/BF02087565</identifier><identifier>PMID: 8174424</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Arginase - pharmacology ; Biological and medical sciences ; Colorimetry ; Cytotoxicity, Immunologic - drug effects ; Dose-Response Relationship, Drug ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; In Vitro Techniques ; Killer Cells, Lymphokine-Activated - drug effects ; Killer Cells, Lymphokine-Activated - immunology ; Killer Cells, Natural - drug effects ; Killer Cells, Natural - immunology ; Medical sciences ; Phytohemagglutinins ; Spleen - immunology ; Stomach Neoplasms - immunology ; Stomach. Duodenum. Small intestine. Colon. Rectum. 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The effect of arginase on the activities of splenic natural killer (NK) cell, phytohemagglutinin activated killer (PAK) cell, and interleukin-2 activated killer (LAK) cell in patients with gastric cancer (N = 12) was evaluated in vitro. These activities in patients (N = 10) with trauma and benign lesions were used as control. The splenic NK and PAK cell activities in patients with gastric cancer were significantly lower than in the controls (P < 0.05), whereas LAK cell activity did not have significant difference. Arginase inhibited all splenic killer cell activities to a similar degree between patients with gastric cancer and the controls. The inhibition was dose-related. These data suggest that arginase may play a positive role in the spread of gastric cancer cells. However, LAK may be a potential approach of immunoadoptive therapy in the future.</description><subject>Arginase - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Colorimetry</subject><subject>Cytotoxicity, Immunologic - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Killer Cells, Lymphokine-Activated - drug effects</subject><subject>Killer Cells, Lymphokine-Activated - immunology</subject><subject>Killer Cells, Natural - drug effects</subject><subject>Killer Cells, Natural - immunology</subject><subject>Medical sciences</subject><subject>Phytohemagglutinins</subject><subject>Spleen - immunology</subject><subject>Stomach Neoplasms - immunology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Killer Cells, Lymphokine-Activated - drug effects</topic><topic>Killer Cells, Lymphokine-Activated - immunology</topic><topic>Killer Cells, Natural - drug effects</topic><topic>Killer Cells, Natural - immunology</topic><topic>Medical sciences</topic><topic>Phytohemagglutinins</topic><topic>Spleen - immunology</topic><topic>Stomach Neoplasms - immunology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, C W</creatorcontrib><creatorcontrib>Chi, C W</creatorcontrib><creatorcontrib>Ho, C K</creatorcontrib><creatorcontrib>Chien, S L</creatorcontrib><creatorcontrib>Liu, W Y</creatorcontrib><creatorcontrib>P'eng, F K</creatorcontrib><creatorcontrib>Wang, S R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, C W</au><au>Chi, C W</au><au>Ho, C K</au><au>Chien, S L</au><au>Liu, W Y</au><au>P'eng, F K</au><au>Wang, S R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of arginase on splenic killer cell activity in patients with gastric cancer</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1994-05-01</date><risdate>1994</risdate><volume>39</volume><issue>5</issue><spage>1107</spage><epage>1112</epage><pages>1107-1112</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Arginase has been detected in high levels in gastric cancer tissues. The effect of arginase on the activities of splenic natural killer (NK) cell, phytohemagglutinin activated killer (PAK) cell, and interleukin-2 activated killer (LAK) cell in patients with gastric cancer (N = 12) was evaluated in vitro. These activities in patients (N = 10) with trauma and benign lesions were used as control. The splenic NK and PAK cell activities in patients with gastric cancer were significantly lower than in the controls (P < 0.05), whereas LAK cell activity did not have significant difference. Arginase inhibited all splenic killer cell activities to a similar degree between patients with gastric cancer and the controls. The inhibition was dose-related. These data suggest that arginase may play a positive role in the spread of gastric cancer cells. However, LAK may be a potential approach of immunoadoptive therapy in the future.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>8174424</pmid><doi>10.1007/BF02087565</doi><tpages>6</tpages></addata></record> |
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| ispartof | Digestive diseases and sciences, 1994-05, Vol.39 (5), p.1107-1112 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Arginase - pharmacology Biological and medical sciences Colorimetry Cytotoxicity, Immunologic - drug effects Dose-Response Relationship, Drug Gastroenterology. Liver. Pancreas. Abdomen Humans In Vitro Techniques Killer Cells, Lymphokine-Activated - drug effects Killer Cells, Lymphokine-Activated - immunology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Medical sciences Phytohemagglutinins Spleen - immunology Stomach Neoplasms - immunology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Effect of arginase on splenic killer cell activity in patients with gastric cancer |
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