The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma
Micrometastases have been detected by immunocytochemical means in the lymph nodes of patients with otherwise node‐negative cancer of the colon and rectum. This study examines the incidence and prognostic significance of nodal micrometastases in Dukes' B carcinoma. Five hundred and fifty‐nine ly...
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| Veröffentlicht in: | The Journal of pathology 1994-02, Vol.172 (2), p.183-187 |
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| container_title | The Journal of pathology |
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| creator | Jeffers, Michael D. O'Dowd, Gerard M. Mulcahy, Hugh Stagg, Mary O'Donoghue, Diarmuid P. Toner, Mary |
| description | Micrometastases have been detected by immunocytochemical means in the lymph nodes of patients with otherwise node‐negative cancer of the colon and rectum. This study examines the incidence and prognostic significance of nodal micrometastases in Dukes' B carcinoma. Five hundred and fifty‐nine lymph nodes from 77 cases of Dukes' B carcinoma were examined for lymph node micrometastases by immunocytochemical staining for cytokeratin AE1:AE3. Micrometastases were detected in 19 cases (25 per cent). Cell clusters were present in ten cases, the remaining nine cases displaying only single cells. The presence of micrometastases was unrelated to age (P = 0·06), sex (P = 0·32), tumour site (P = 0·37), tumour size (P = 0·67), or tumour differentiation (P = 0·66). Ten‐year survival estimates by the Kaplan–Meier lifetable method was 47 per cent in patients with and without micrometastases (χ2 = 0·35 and 1 df, P = ns). The presence of nodal micrometastases detectable only by immunocytochemistry in patients with Dukes' B colorectal cancer does not justify reassignment to a more advanced disease stage. |
| doi_str_mv | 10.1002/path.1711720205 |
| format | Article |
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This study examines the incidence and prognostic significance of nodal micrometastases in Dukes' B carcinoma. Five hundred and fifty‐nine lymph nodes from 77 cases of Dukes' B carcinoma were examined for lymph node micrometastases by immunocytochemical staining for cytokeratin AE1:AE3. Micrometastases were detected in 19 cases (25 per cent). Cell clusters were present in ten cases, the remaining nine cases displaying only single cells. The presence of micrometastases was unrelated to age (P = 0·06), sex (P = 0·32), tumour site (P = 0·37), tumour size (P = 0·67), or tumour differentiation (P = 0·66). Ten‐year survival estimates by the Kaplan–Meier lifetable method was 47 per cent in patients with and without micrometastases (χ2 = 0·35 and 1 df, P = ns). The presence of nodal micrometastases detectable only by immunocytochemistry in patients with Dukes' B colorectal cancer does not justify reassignment to a more advanced disease stage.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.1711720205</identifier><identifier>PMID: 7513353</identifier><identifier>CODEN: JPTLAS</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Aged ; Biological and medical sciences ; Colorectal carcinoma ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; cytokeratin ; Epithelium - chemistry ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; immunocytochemistry ; Immunohistochemistry ; Incidence ; Keratins - analysis ; lymph node micrometastases ; Lymphatic Metastasis - diagnosis ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Prognosis ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Rate ; Tumors</subject><ispartof>The Journal of pathology, 1994-02, Vol.172 (2), p.183-187</ispartof><rights>Copyright © 1994 John Wiley & Sons, Ltd.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4775-15b23d82fbb66065d6d65321e98f0803d0fed0fe2adc0c2a627b030ab437400f3</citedby><cites>FETCH-LOGICAL-c4775-15b23d82fbb66065d6d65321e98f0803d0fed0fe2adc0c2a627b030ab437400f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.1711720205$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.1711720205$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4000873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7513353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeffers, Michael D.</creatorcontrib><creatorcontrib>O'Dowd, Gerard M.</creatorcontrib><creatorcontrib>Mulcahy, Hugh</creatorcontrib><creatorcontrib>Stagg, Mary</creatorcontrib><creatorcontrib>O'Donoghue, Diarmuid P.</creatorcontrib><creatorcontrib>Toner, Mary</creatorcontrib><title>The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>Micrometastases have been detected by immunocytochemical means in the lymph nodes of patients with otherwise node‐negative cancer of the colon and rectum. This study examines the incidence and prognostic significance of nodal micrometastases in Dukes' B carcinoma. Five hundred and fifty‐nine lymph nodes from 77 cases of Dukes' B carcinoma were examined for lymph node micrometastases by immunocytochemical staining for cytokeratin AE1:AE3. Micrometastases were detected in 19 cases (25 per cent). Cell clusters were present in ten cases, the remaining nine cases displaying only single cells. The presence of micrometastases was unrelated to age (P = 0·06), sex (P = 0·32), tumour site (P = 0·37), tumour size (P = 0·67), or tumour differentiation (P = 0·66). Ten‐year survival estimates by the Kaplan–Meier lifetable method was 47 per cent in patients with and without micrometastases (χ2 = 0·35 and 1 df, P = ns). The presence of nodal micrometastases detectable only by immunocytochemistry in patients with Dukes' B colorectal cancer does not justify reassignment to a more advanced disease stage.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>cytokeratin</subject><subject>Epithelium - chemistry</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>immunocytochemistry</subject><subject>Immunohistochemistry</subject><subject>Incidence</subject><subject>Keratins - analysis</subject><subject>lymph node micrometastases</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGL1DAUxoMo67h69iTkIN66-5I0SYunddAdYVEPI4KXkKav22jTdJsOOv-9GWYY8SQk5PD93nvf-0LISwZXDIBfT3bpr5hmTHPgIB-RFYNaFXVVq8dklQleiJLpp-RZSj8AoK6lvCAXWjIhpFiRadsjneZ4P8a0eEeTvx99550dHdLYUR_Cboy9T0t0PYYsDMOetrigW7Clwz5MPR1jizRrcwy42JQPJupH6uIQ5wzagTo7Oz_GYJ-TJ50dEr44vZfk64f32_WmuPt8-3F9c1e4UmtZMNlw0Va8axqlQMlWtUoKzrCuOqhAtNDh4XLbOnDcKq4bEGCbUugSoBOX5M2xb17uYYdpMcEnh8NgR4y7ZLQqVVVClcHrI5jtpzRjZ6bZBzvvDQNzyNgcMjZ_M84Vr06td03A9syfQs3665NuU86rm3OYPp2xbA8qfcDeHrFffsD9_6aaLzfbzT8mimN1_hr8fa6280-jtNDSfPt0a_KG39lmvTXvxB9aSaeA</recordid><startdate>199402</startdate><enddate>199402</enddate><creator>Jeffers, Michael D.</creator><creator>O'Dowd, Gerard M.</creator><creator>Mulcahy, Hugh</creator><creator>Stagg, Mary</creator><creator>O'Donoghue, Diarmuid P.</creator><creator>Toner, Mary</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199402</creationdate><title>The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma</title><author>Jeffers, Michael D. ; O'Dowd, Gerard M. ; Mulcahy, Hugh ; Stagg, Mary ; O'Donoghue, Diarmuid P. ; Toner, Mary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4775-15b23d82fbb66065d6d65321e98f0803d0fed0fe2adc0c2a627b030ab437400f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>cytokeratin</topic><topic>Epithelium - chemistry</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>immunocytochemistry</topic><topic>Immunohistochemistry</topic><topic>Incidence</topic><topic>Keratins - analysis</topic><topic>lymph node micrometastases</topic><topic>Lymphatic Metastasis - diagnosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeffers, Michael D.</creatorcontrib><creatorcontrib>O'Dowd, Gerard M.</creatorcontrib><creatorcontrib>Mulcahy, Hugh</creatorcontrib><creatorcontrib>Stagg, Mary</creatorcontrib><creatorcontrib>O'Donoghue, Diarmuid P.</creatorcontrib><creatorcontrib>Toner, Mary</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeffers, Michael D.</au><au>O'Dowd, Gerard M.</au><au>Mulcahy, Hugh</au><au>Stagg, Mary</au><au>O'Donoghue, Diarmuid P.</au><au>Toner, Mary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>1994-02</date><risdate>1994</risdate><volume>172</volume><issue>2</issue><spage>183</spage><epage>187</epage><pages>183-187</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><coden>JPTLAS</coden><abstract>Micrometastases have been detected by immunocytochemical means in the lymph nodes of patients with otherwise node‐negative cancer of the colon and rectum. This study examines the incidence and prognostic significance of nodal micrometastases in Dukes' B carcinoma. Five hundred and fifty‐nine lymph nodes from 77 cases of Dukes' B carcinoma were examined for lymph node micrometastases by immunocytochemical staining for cytokeratin AE1:AE3. Micrometastases were detected in 19 cases (25 per cent). Cell clusters were present in ten cases, the remaining nine cases displaying only single cells. The presence of micrometastases was unrelated to age (P = 0·06), sex (P = 0·32), tumour site (P = 0·37), tumour size (P = 0·67), or tumour differentiation (P = 0·66). Ten‐year survival estimates by the Kaplan–Meier lifetable method was 47 per cent in patients with and without micrometastases (χ2 = 0·35 and 1 df, P = ns). The presence of nodal micrometastases detectable only by immunocytochemistry in patients with Dukes' B colorectal cancer does not justify reassignment to a more advanced disease stage.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>7513353</pmid><doi>10.1002/path.1711720205</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Colorectal carcinoma Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology cytokeratin Epithelium - chemistry Female Gastroenterology. Liver. Pancreas. Abdomen Humans immunocytochemistry Immunohistochemistry Incidence Keratins - analysis lymph node micrometastases Lymphatic Metastasis - diagnosis Male Medical sciences Middle Aged Neoplasm Staging Prognosis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Rate Tumors |
| title | The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma |
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