Synthesis, Characterization, and Analytical Studies of Adosupine, a Potential New Drug for Urinary Incontinence
□ The synthesis and the spectroscopic characterization of a new potential drug for urinary incontinence, adosupine, is described. Adosupine and its potential synthesis impurities were analyzed by a new HPLC method that was developed with a C18 reversed-phase column. The analysis was made under isocr...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1994-02, Vol.83 (2), p.137-142 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 83 |
| creator | Perico, A. Triolo, A. Viti, G. Mannucci, C. Caviglioli, G. Cocchini, A. Pestellini, V. Paoli, P. Dapporto, P. |
| description | □ The synthesis and the spectroscopic characterization of a new potential drug for urinary incontinence, adosupine, is described. Adosupine and its potential synthesis impurities were analyzed by a new HPLC method that was developed with a C18 reversed-phase column. The analysis was made under isocratic conditions, with a mobile phase of acetonitrile:water (15:85, v/v). Resolution of all synthesis Impurities was allowed. The method was also applied to stability studies of adosupine in solid state and in solution under different conditions. With the conditions used, only one degradation product was shown by HPLC analysis; it was isolated, characterized, and Identified as the hydrolysis product of the lactam ring present In the adosupine structure. |
| doi_str_mv | 10.1002/jps.2600830206 |
| format | Article |
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Adosupine and its potential synthesis impurities were analyzed by a new HPLC method that was developed with a C18 reversed-phase column. The analysis was made under isocratic conditions, with a mobile phase of acetonitrile:water (15:85, v/v). Resolution of all synthesis Impurities was allowed. The method was also applied to stability studies of adosupine in solid state and in solution under different conditions. With the conditions used, only one degradation product was shown by HPLC analysis; it was isolated, characterized, and Identified as the hydrolysis product of the lactam ring present In the adosupine structure.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600830206</identifier><identifier>PMID: 8169779</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Biological and medical sciences ; Chromatography, High Pressure Liquid ; Crystallography, X-Ray ; Dibenzazepines - analysis ; Dibenzazepines - chemical synthesis ; Dibenzazepines - chemistry ; Drug Stability ; Hydrolysis ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Medical sciences ; Molecular Conformation ; Pharmacology. Drug treatments ; Urinary Incontinence - drug therapy ; Urinary system</subject><ispartof>Journal of pharmaceutical sciences, 1994-02, Vol.83 (2), p.137-142</ispartof><rights>1994 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4566-4b14bed9bbbccbbf2ad12873f11faad428ef7461871774b117bdf7e88a7c11ef3</citedby><cites>FETCH-LOGICAL-c4566-4b14bed9bbbccbbf2ad12873f11faad428ef7461871774b117bdf7e88a7c11ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600830206$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600830206$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3927703$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8169779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perico, A.</creatorcontrib><creatorcontrib>Triolo, A.</creatorcontrib><creatorcontrib>Viti, G.</creatorcontrib><creatorcontrib>Mannucci, C.</creatorcontrib><creatorcontrib>Caviglioli, G.</creatorcontrib><creatorcontrib>Cocchini, A.</creatorcontrib><creatorcontrib>Pestellini, V.</creatorcontrib><creatorcontrib>Paoli, P.</creatorcontrib><creatorcontrib>Dapporto, P.</creatorcontrib><title>Synthesis, Characterization, and Analytical Studies of Adosupine, a Potential New Drug for Urinary Incontinence</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>□ The synthesis and the spectroscopic characterization of a new potential drug for urinary incontinence, adosupine, is described. Adosupine and its potential synthesis impurities were analyzed by a new HPLC method that was developed with a C18 reversed-phase column. The analysis was made under isocratic conditions, with a mobile phase of acetonitrile:water (15:85, v/v). Resolution of all synthesis Impurities was allowed. The method was also applied to stability studies of adosupine in solid state and in solution under different conditions. With the conditions used, only one degradation product was shown by HPLC analysis; it was isolated, characterized, and Identified as the hydrolysis product of the lactam ring present In the adosupine structure.</description><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Crystallography, X-Ray</subject><subject>Dibenzazepines - analysis</subject><subject>Dibenzazepines - chemical synthesis</subject><subject>Dibenzazepines - chemistry</subject><subject>Drug Stability</subject><subject>Hydrolysis</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mass Spectrometry</subject><subject>Medical sciences</subject><subject>Molecular Conformation</subject><subject>Pharmacology. Drug treatments</subject><subject>Urinary Incontinence - drug therapy</subject><subject>Urinary system</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9vFCEYhonR1LV69WbCwXjqrDA_YOa42dVabdYma9MjYeDDUmdhBca6_vXSzGaNB-OJw_u8Hx8PCL2kZE4JKd_e7eK8ZIS0FSkJe4RmtClJwQjlj9EsA2VRNXX3FD2L8Y4QwkjTnKCTlrKO826G_Gbv0i1EG8_w8lYGqRIE-0sm690Zlk7jhZPDPlklB7xJo7YQsTd4oX0cd9ZBhvCVT-CSzcQa7vEqjF-x8QFfB-tk2OMLp3yOHTgFz9ETI4cILw7nKbp-_-7L8kNx-fn8Yrm4LFTdMFbUPa170F3f90r1vSmlpmXLK0OpkVLXZQuG14y2nHKeYcp7bTi0reSKUjDVKXozzd0F_32EmMTWRgXDIB34MQrOatbSrsngfAJV8DEGMGIX7DavLSgRD4ZFNiz-GM6FV4fJY78FfcQPSnP--pDLmKWZIJ2y8YhVXck5qTLWTdi9HWD_n0vFx6vNXysUU9fGBD-PXRm-CcYr3oib9blYrT9Rsl7V4ibz7cRDNv7DQhBR2Yff0DaASkJ7-6_X_gb6Lbec</recordid><startdate>199402</startdate><enddate>199402</enddate><creator>Perico, A.</creator><creator>Triolo, A.</creator><creator>Viti, G.</creator><creator>Mannucci, C.</creator><creator>Caviglioli, G.</creator><creator>Cocchini, A.</creator><creator>Pestellini, V.</creator><creator>Paoli, P.</creator><creator>Dapporto, P.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199402</creationdate><title>Synthesis, Characterization, and Analytical Studies of Adosupine, a Potential New Drug for Urinary Incontinence</title><author>Perico, A. ; Triolo, A. ; Viti, G. ; Mannucci, C. ; Caviglioli, G. ; Cocchini, A. ; Pestellini, V. ; Paoli, P. ; Dapporto, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4566-4b14bed9bbbccbbf2ad12873f11faad428ef7461871774b117bdf7e88a7c11ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Crystallography, X-Ray</topic><topic>Dibenzazepines - analysis</topic><topic>Dibenzazepines - chemical synthesis</topic><topic>Dibenzazepines - chemistry</topic><topic>Drug Stability</topic><topic>Hydrolysis</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mass Spectrometry</topic><topic>Medical sciences</topic><topic>Molecular Conformation</topic><topic>Pharmacology. Drug treatments</topic><topic>Urinary Incontinence - drug therapy</topic><topic>Urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perico, A.</creatorcontrib><creatorcontrib>Triolo, A.</creatorcontrib><creatorcontrib>Viti, G.</creatorcontrib><creatorcontrib>Mannucci, C.</creatorcontrib><creatorcontrib>Caviglioli, G.</creatorcontrib><creatorcontrib>Cocchini, A.</creatorcontrib><creatorcontrib>Pestellini, V.</creatorcontrib><creatorcontrib>Paoli, P.</creatorcontrib><creatorcontrib>Dapporto, P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perico, A.</au><au>Triolo, A.</au><au>Viti, G.</au><au>Mannucci, C.</au><au>Caviglioli, G.</au><au>Cocchini, A.</au><au>Pestellini, V.</au><au>Paoli, P.</au><au>Dapporto, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, Characterization, and Analytical Studies of Adosupine, a Potential New Drug for Urinary Incontinence</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1994-02</date><risdate>1994</risdate><volume>83</volume><issue>2</issue><spage>137</spage><epage>142</epage><pages>137-142</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>□ The synthesis and the spectroscopic characterization of a new potential drug for urinary incontinence, adosupine, is described. Adosupine and its potential synthesis impurities were analyzed by a new HPLC method that was developed with a C18 reversed-phase column. The analysis was made under isocratic conditions, with a mobile phase of acetonitrile:water (15:85, v/v). Resolution of all synthesis Impurities was allowed. The method was also applied to stability studies of adosupine in solid state and in solution under different conditions. With the conditions used, only one degradation product was shown by HPLC analysis; it was isolated, characterized, and Identified as the hydrolysis product of the lactam ring present In the adosupine structure.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>8169779</pmid><doi>10.1002/jps.2600830206</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1994-02, Vol.83 (2), p.137-142 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Chromatography, High Pressure Liquid Crystallography, X-Ray Dibenzazepines - analysis Dibenzazepines - chemical synthesis Dibenzazepines - chemistry Drug Stability Hydrolysis Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Molecular Conformation Pharmacology. Drug treatments Urinary Incontinence - drug therapy Urinary system |
| title | Synthesis, Characterization, and Analytical Studies of Adosupine, a Potential New Drug for Urinary Incontinence |
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