The 24-h pattern and rate of leucine oxidation, with particular reference to tracer estimates of leucine requirements in healthy adults
Daily leucine oxidation and derived values for whole-body leucine balance, obtained by continuous measurement throughout a 24-h period, were compared with those predicted from short-term measurements during fasted and fed states in five healthy adults studied during two 6-d experimental diet periods...
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| Veröffentlicht in: | The American journal of clinical nutrition 1994-05, Vol.59 (5), p.1012-1020 |
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| creator | El-Khoury, AE Fukagawa, NK Sánchez, M Tsay, RH Gleason, RE Chapman, TE Young, VR |
| description | Daily leucine oxidation and derived values for whole-body leucine balance, obtained by continuous measurement throughout a 24-h period, were compared with those predicted from short-term measurements during fasted and fed states in five healthy adults studied during two 6-d experimental diet periods, each immediately followed by a 24-h continuous intravenous tracer infusion of l-[l-13C]leucine. Leucine intake was either 14 or 38.3 mg · kg−1· d−1.Mean measured daily leucine oxidation (mg leucine · kg−1· d−1) was 27.8 and 45.2 for the 14-and 38.3-mg intakes, respectively. Oxidation rates predicted by extrapolation of rates measured during the final hour of fasting (15 h after last meal) and the 5th h of feeding were ≈ 12% higher (P< 0.01) than measured rates for both diets. For the prediction based on the 12th h of fasting and 5th h of feeding, it was 4% higher or 0.4% lower than measured rates for the 38.3- and 14-mg intakes, respectively. Hence, relatively small differences exist between measured vs predicted estimates of daily leucine oxidation and balance. These studies support previous conclusions that the current, international requirement value for leucine in healthy adults is far too low. |
| doi_str_mv | 10.1093/ajcn/59.5.1012 |
| format | Article |
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Leucine intake was either 14 or 38.3 mg · kg−1· d−1.Mean measured daily leucine oxidation (mg leucine · kg−1· d−1) was 27.8 and 45.2 for the 14-and 38.3-mg intakes, respectively. Oxidation rates predicted by extrapolation of rates measured during the final hour of fasting (15 h after last meal) and the 5th h of feeding were ≈ 12% higher (P< 0.01) than measured rates for both diets. For the prediction based on the 12th h of fasting and 5th h of feeding, it was 4% higher or 0.4% lower than measured rates for the 38.3- and 14-mg intakes, respectively. Hence, relatively small differences exist between measured vs predicted estimates of daily leucine oxidation and balance. These studies support previous conclusions that the current, international requirement value for leucine in healthy adults is far too low.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/59.5.1012</identifier><identifier>PMID: 8172084</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Adult ; ADULTE ; ADULTOS ; BESOIN NUTRITIONNEL ; Biological and medical sciences ; Carbon Isotopes ; Fasting ; Female ; FEMME ; FISIOLOGIA DE LA NUTRICION ; Food ; HOMBRES ; HOMME ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Keto Acids - blood ; Kinetics ; LEUCINA ; LEUCINE ; Leucine - administration & dosage ; Leucine - metabolism ; Male ; MASSACHUSETTS ; Medical sciences ; Metabolic diseases ; MUJERES ; NECESIDADES DE NUTRIENTES ; Nutritional Requirements ; OXIDACION ; Oxidation-Reduction ; OXYDATION ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; PHYSIOLOGIE DE LA NUTRITION ; PLASMA SANGUIN ; PLASMA SANGUINEO ; RITMOS BIOLOGICOS ; RYTHME BIOLOGIQUE ; TECHNIQUE DE PREVISION ; TECHNIQUE DES TRACEURS ; TECNICAS DE PREDICCION ; TECNICAS DE TRAZADORES</subject><ispartof>The American journal of clinical nutrition, 1994-05, Vol.59 (5), p.1012-1020</ispartof><rights>1994 American Society for Nutrition.</rights><rights>1994 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. 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Leucine intake was either 14 or 38.3 mg · kg−1· d−1.Mean measured daily leucine oxidation (mg leucine · kg−1· d−1) was 27.8 and 45.2 for the 14-and 38.3-mg intakes, respectively. Oxidation rates predicted by extrapolation of rates measured during the final hour of fasting (15 h after last meal) and the 5th h of feeding were ≈ 12% higher (P< 0.01) than measured rates for both diets. For the prediction based on the 12th h of fasting and 5th h of feeding, it was 4% higher or 0.4% lower than measured rates for the 38.3- and 14-mg intakes, respectively. Hence, relatively small differences exist between measured vs predicted estimates of daily leucine oxidation and balance. These studies support previous conclusions that the current, international requirement value for leucine in healthy adults is far too low.</description><subject>Adult</subject><subject>ADULTE</subject><subject>ADULTOS</subject><subject>BESOIN NUTRITIONNEL</subject><subject>Biological and medical sciences</subject><subject>Carbon Isotopes</subject><subject>Fasting</subject><subject>Female</subject><subject>FEMME</subject><subject>FISIOLOGIA DE LA NUTRICION</subject><subject>Food</subject><subject>HOMBRES</subject><subject>HOMME</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Keto Acids - blood</subject><subject>Kinetics</subject><subject>LEUCINA</subject><subject>LEUCINE</subject><subject>Leucine - administration & dosage</subject><subject>Leucine - metabolism</subject><subject>Male</subject><subject>MASSACHUSETTS</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>MUJERES</subject><subject>NECESIDADES DE NUTRIENTES</subject><subject>Nutritional Requirements</subject><subject>OXIDACION</subject><subject>Oxidation-Reduction</subject><subject>OXYDATION</subject><subject>Pathology. 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Miscellaneous investigative techniques</topic><topic>PHYSIOLOGIE DE LA NUTRITION</topic><topic>PLASMA SANGUIN</topic><topic>PLASMA SANGUINEO</topic><topic>RITMOS BIOLOGICOS</topic><topic>RYTHME BIOLOGIQUE</topic><topic>TECHNIQUE DE PREVISION</topic><topic>TECHNIQUE DES TRACEURS</topic><topic>TECNICAS DE PREDICCION</topic><topic>TECNICAS DE TRAZADORES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Khoury, AE</creatorcontrib><creatorcontrib>Fukagawa, NK</creatorcontrib><creatorcontrib>Sánchez, M</creatorcontrib><creatorcontrib>Tsay, RH</creatorcontrib><creatorcontrib>Gleason, RE</creatorcontrib><creatorcontrib>Chapman, TE</creatorcontrib><creatorcontrib>Young, VR</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Khoury, AE</au><au>Fukagawa, NK</au><au>Sánchez, M</au><au>Tsay, RH</au><au>Gleason, RE</au><au>Chapman, TE</au><au>Young, VR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The 24-h pattern and rate of leucine oxidation, with particular reference to tracer estimates of leucine requirements in healthy adults</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1994-05-01</date><risdate>1994</risdate><volume>59</volume><issue>5</issue><spage>1012</spage><epage>1020</epage><pages>1012-1020</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Daily leucine oxidation and derived values for whole-body leucine balance, obtained by continuous measurement throughout a 24-h period, were compared with those predicted from short-term measurements during fasted and fed states in five healthy adults studied during two 6-d experimental diet periods, each immediately followed by a 24-h continuous intravenous tracer infusion of l-[l-13C]leucine. Leucine intake was either 14 or 38.3 mg · kg−1· d−1.Mean measured daily leucine oxidation (mg leucine · kg−1· d−1) was 27.8 and 45.2 for the 14-and 38.3-mg intakes, respectively. Oxidation rates predicted by extrapolation of rates measured during the final hour of fasting (15 h after last meal) and the 5th h of feeding were ≈ 12% higher (P< 0.01) than measured rates for both diets. For the prediction based on the 12th h of fasting and 5th h of feeding, it was 4% higher or 0.4% lower than measured rates for the 38.3- and 14-mg intakes, respectively. Hence, relatively small differences exist between measured vs predicted estimates of daily leucine oxidation and balance. These studies support previous conclusions that the current, international requirement value for leucine in healthy adults is far too low.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>8172084</pmid><doi>10.1093/ajcn/59.5.1012</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0002-9165 |
| ispartof | The American journal of clinical nutrition, 1994-05, Vol.59 (5), p.1012-1020 |
| issn | 0002-9165 1938-3207 |
| language | eng |
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| subjects | Adult ADULTE ADULTOS BESOIN NUTRITIONNEL Biological and medical sciences Carbon Isotopes Fasting Female FEMME FISIOLOGIA DE LA NUTRICION Food HOMBRES HOMME Humans Investigative techniques, diagnostic techniques (general aspects) Keto Acids - blood Kinetics LEUCINA LEUCINE Leucine - administration & dosage Leucine - metabolism Male MASSACHUSETTS Medical sciences Metabolic diseases MUJERES NECESIDADES DE NUTRIENTES Nutritional Requirements OXIDACION Oxidation-Reduction OXYDATION Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques PHYSIOLOGIE DE LA NUTRITION PLASMA SANGUIN PLASMA SANGUINEO RITMOS BIOLOGICOS RYTHME BIOLOGIQUE TECHNIQUE DE PREVISION TECHNIQUE DES TRACEURS TECNICAS DE PREDICCION TECNICAS DE TRAZADORES |
| title | The 24-h pattern and rate of leucine oxidation, with particular reference to tracer estimates of leucine requirements in healthy adults |
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