Reexpression of Cartilage-Specific Genes by Dedifferentiated Human Articular Chondrocytes Cultured in Alginate Beads

We have used the three-dimensional culture system in alginate beads to redifferentiate human articular chondrocytes which were first expanded on a plastic support. After 15 days in alginate beads, electron microscopy showed that cells had synthesized an extracellular matrix containing collagen fibri...

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Veröffentlicht in:	Experimental cell research 1994-05, Vol.212 (1), p.97-104
Hauptverfasser:	Bonaventure, J., Kadhom, N., Cohen-Solal, L., Ng, K.H., Bourguignon, J., Lasselin, C., Freisinger, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginates Base Sequence Biological and medical sciences Blotting, Northern Capsules Cartilage, Articular - cytology Cartilage, Articular - embryology Cartilage, Articular - metabolism Cell Differentiation - physiology Collagen - biosynthesis Collagen - genetics Culture Techniques - methods Fundamental and applied biological sciences. Psychology Gene Expression Humans Hydroxyproline - metabolism Molecular Sequence Data Polymerase Chain Reaction Procollagen - secretion Proline - metabolism RNA, Messenger - biosynthesis Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system
Online-Zugang:	Volltext
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