δ-Aminolevulinic acid dehydratase inactivation by uroporphyrin I in light and darkness
1. 1. The action of uroporphyrin I on erythrocytic ALA-D activity under dark and light conditions was examined. 2. 2. Photo and non-photoinactivation of ALA-D induced by uroporphyrin I were observed. 3. 3. Both effects were dependent on uroporphyrin concentration, temperature and time of exposure of...
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| Veröffentlicht in: | International journal of biochemistry 1994-02, Vol.26 (2), p.255-258 |
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| container_end_page | 258 |
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| container_issue | 2 |
| container_start_page | 255 |
| container_title | International journal of biochemistry |
| container_volume | 26 |
| creator | Afonso, Susana Graciela Chinarro, Sagrario de Salamanca, Rafael Enriquez Del Carmen Batlle, Alcira Maria |
| description | 1.
1. The action of uroporphyrin I on erythrocytic ALA-D activity under dark and light conditions was examined.
2.
2. Photo and non-photoinactivation of ALA-D induced by uroporphyrin I were observed.
3.
3. Both effects were dependent on uroporphyrin concentration, temperature and time of exposure of the protein to the porphyrin.
4.
4. Light-dependent effect of uroporphyrin I is related with the phototoxicity of porphyrins and could be produced by primary amino acid photooxidation followed by secondary cross-linking of the protein.
5.
5. Light-dependent effect of uroporphyrin I could be ascribed to a direct enzyme inhibition due to binding of the porphyrin to the protein inducing structural changes at or near its active site. |
| doi_str_mv | 10.1016/0020-711X(94)90153-8 |
| format | Article |
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1. The action of uroporphyrin I on erythrocytic ALA-D activity under dark and light conditions was examined.
2.
2. Photo and non-photoinactivation of ALA-D induced by uroporphyrin I were observed.
3.
3. Both effects were dependent on uroporphyrin concentration, temperature and time of exposure of the protein to the porphyrin.
4.
4. Light-dependent effect of uroporphyrin I is related with the phototoxicity of porphyrins and could be produced by primary amino acid photooxidation followed by secondary cross-linking of the protein.
5.
5. Light-dependent effect of uroporphyrin I could be ascribed to a direct enzyme inhibition due to binding of the porphyrin to the protein inducing structural changes at or near its active site.</description><identifier>ISSN: 0020-711X</identifier><identifier>DOI: 10.1016/0020-711X(94)90153-8</identifier><identifier>PMID: 8174759</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Darkness ; Humans ; Light ; Porphobilinogen Synthase - antagonists & inhibitors ; Temperature ; Uroporphyrins - pharmacology</subject><ispartof>International journal of biochemistry, 1994-02, Vol.26 (2), p.255-258</ispartof><rights>1994</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-c3b91f90f72eb17b8449e6ad0021d57d97c456523a1acf740f45cd5f7db00e403</citedby><cites>FETCH-LOGICAL-c357t-c3b91f90f72eb17b8449e6ad0021d57d97c456523a1acf740f45cd5f7db00e403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8174759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Afonso, Susana Graciela</creatorcontrib><creatorcontrib>Chinarro, Sagrario</creatorcontrib><creatorcontrib>de Salamanca, Rafael Enriquez</creatorcontrib><creatorcontrib>Del Carmen Batlle, Alcira Maria</creatorcontrib><title>δ-Aminolevulinic acid dehydratase inactivation by uroporphyrin I in light and darkness</title><title>International journal of biochemistry</title><addtitle>Int J Biochem</addtitle><description>1.
1. The action of uroporphyrin I on erythrocytic ALA-D activity under dark and light conditions was examined.
2.
2. Photo and non-photoinactivation of ALA-D induced by uroporphyrin I were observed.
3.
3. Both effects were dependent on uroporphyrin concentration, temperature and time of exposure of the protein to the porphyrin.
4.
4. Light-dependent effect of uroporphyrin I is related with the phototoxicity of porphyrins and could be produced by primary amino acid photooxidation followed by secondary cross-linking of the protein.
5.
5. Light-dependent effect of uroporphyrin I could be ascribed to a direct enzyme inhibition due to binding of the porphyrin to the protein inducing structural changes at or near its active site.</description><subject>Darkness</subject><subject>Humans</subject><subject>Light</subject><subject>Porphobilinogen Synthase - antagonists & inhibitors</subject><subject>Temperature</subject><subject>Uroporphyrins - pharmacology</subject><issn>0020-711X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwyAYxzlo5px-A016MnqowgalXEyWxZclS7xo9EYoPHVoSyu0S_a9_Bx-JplbdvQCCf-X5-GH0BnB1wST7AbjMU45IW-Xgl4JTNgkzQ_QcP98hI5D-MCYiJySARrkhFPOxBC9_nyn09q6poJVX1lndaK0NYmB5dp41akAiXVKd3alOtu4pFgnvW_axrfLtbcumUc5qez7skuUiznlPx2EcIIOS1UFON3dI_Ryf_c8e0wXTw_z2XSR6gnjXTwLQUqBSz6GgvAip1RApkxcnBjGjeCasoyNJ4ooXXKKS8q0YSU3BcZA8WSELra9rW--egidrG3QUFXKQdMHyTOaseiLRro1at-E4KGUrbe18mtJsNwwlBtYcgNLCir_GMo8xs53_X1Rg9mHdgCjfrvVIX5yZcHLoC04DcZ60J00jf1_wC8vpoRv</recordid><startdate>19940201</startdate><enddate>19940201</enddate><creator>Afonso, Susana Graciela</creator><creator>Chinarro, Sagrario</creator><creator>de Salamanca, Rafael Enriquez</creator><creator>Del Carmen Batlle, Alcira Maria</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940201</creationdate><title>δ-Aminolevulinic acid dehydratase inactivation by uroporphyrin I in light and darkness</title><author>Afonso, Susana Graciela ; Chinarro, Sagrario ; de Salamanca, Rafael Enriquez ; Del Carmen Batlle, Alcira Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-c3b91f90f72eb17b8449e6ad0021d57d97c456523a1acf740f45cd5f7db00e403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Darkness</topic><topic>Humans</topic><topic>Light</topic><topic>Porphobilinogen Synthase - antagonists & inhibitors</topic><topic>Temperature</topic><topic>Uroporphyrins - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>Afonso, Susana Graciela</creatorcontrib><creatorcontrib>Chinarro, Sagrario</creatorcontrib><creatorcontrib>de Salamanca, Rafael Enriquez</creatorcontrib><creatorcontrib>Del Carmen Batlle, Alcira Maria</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Afonso, Susana Graciela</au><au>Chinarro, Sagrario</au><au>de Salamanca, Rafael Enriquez</au><au>Del Carmen Batlle, Alcira Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>δ-Aminolevulinic acid dehydratase inactivation by uroporphyrin I in light and darkness</atitle><jtitle>International journal of biochemistry</jtitle><addtitle>Int J Biochem</addtitle><date>1994-02-01</date><risdate>1994</risdate><volume>26</volume><issue>2</issue><spage>255</spage><epage>258</epage><pages>255-258</pages><issn>0020-711X</issn><abstract>1.
1. The action of uroporphyrin I on erythrocytic ALA-D activity under dark and light conditions was examined.
2.
2. Photo and non-photoinactivation of ALA-D induced by uroporphyrin I were observed.
3.
3. Both effects were dependent on uroporphyrin concentration, temperature and time of exposure of the protein to the porphyrin.
4.
4. Light-dependent effect of uroporphyrin I is related with the phototoxicity of porphyrins and could be produced by primary amino acid photooxidation followed by secondary cross-linking of the protein.
5.
5. Light-dependent effect of uroporphyrin I could be ascribed to a direct enzyme inhibition due to binding of the porphyrin to the protein inducing structural changes at or near its active site.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>8174759</pmid><doi>10.1016/0020-711X(94)90153-8</doi><tpages>4</tpages></addata></record> |
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| ispartof | International journal of biochemistry, 1994-02, Vol.26 (2), p.255-258 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Darkness Humans Light Porphobilinogen Synthase - antagonists & inhibitors Temperature Uroporphyrins - pharmacology |
| title | δ-Aminolevulinic acid dehydratase inactivation by uroporphyrin I in light and darkness |
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