In vitro Photoinduced Cytotoxicity and DNA Binding Properties of Psoralen and Coumarin Conjugates of Netropsin Analogs: DNA Sequence-Directed Alkylation and Cross-Link Formation

he synthesis, DNA binding and in vitro photoinduced cytotoxic properties of a number of minor groove and sequence-directed psoralen and coumarin conjugates of pyrrole- and imidazole-containing distamycin analogues 2-5 are described. Results from an ethidium displacement assay on calf thymus and T4 D...

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Veröffentlicht in:	Journal of medicinal chemistry 1994-04, Vol.37 (8), p.1208-1213
Hauptverfasser:	Lee, Moses, Roldan, Mary C, Haskell, Margaret K, McAdam, Simon R, Hartley, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Antineoplastic Agents - chemical synthesis Base Composition Biological and medical sciences Coumarins - metabolism Coumarins - pharmacology Cross-Linking Reagents DNA - chemistry DNA - metabolism Ficusin - metabolism Ficusin - pharmacology Furocoumarins - chemical synthesis Furocoumarins - metabolism Furocoumarins - pharmacology Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Light Medical sciences Molecular Structure Netropsin - analogs & derivatives Netropsin - metabolism Netropsin - pharmacology Photochemistry Photochemotherapy Photoradiation therapy and photosensitizing agent Pyrroles - chemical synthesis Pyrroles - metabolism Pyrroles - pharmacology Structure-Activity Relationship Treatment with physical agents Treatment. General aspects Tumor Cells, Cultured Tumors
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