Pharmacokinetic overview of indomethacin and sustained-release indomethacin
Indomethacin has a moderately short half-life, usually requiring dosing twice a day or three times a day. A more convenient once or twice daily regimen is made possible with a sustained-release formulation. Following multiple-dose administration of either sustained-release indomethacin (Indocin SR)...
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| Veröffentlicht in: | The American journal of medicine 1985-10, Vol.79 (4), p.3-12 |
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| container_title | The American journal of medicine |
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| creator | Yeh, Kuang C. |
| description | Indomethacin has a moderately short half-life, usually requiring dosing twice a day or three times a day. A more convenient once or twice daily regimen is made possible with a sustained-release formulation. Following multiple-dose administration of either sustained-release indomethacin (Indocin SR) or conventional indomethacin, drug accumulation is low. Clinical studies indicate comparable safety and efficacy profiles between the two preparations. Pharmacokinetic information on both dosage forms is reviewed. |
| doi_str_mv | 10.1016/0002-9343(85)90510-8 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | The American journal of medicine, 1985-10, Vol.79 (4), p.3-12 |
| issn | 0002-9343 1555-7162 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76465009 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Absorption Administration, Oral Adult Aged Antacids - pharmacology Biological Availability Circadian Rhythm Delayed-Action Preparations Enterohepatic Circulation Fasting Food Half-Life Humans Indomethacin - blood Indomethacin - metabolism Kinetics Middle Aged Protein Binding Tissue Distribution |
| title | Pharmacokinetic overview of indomethacin and sustained-release indomethacin |
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