Distribution of calpain I, an enzyme associated with degenerative activity, in rat brain
The calcium-activated protease calpain I was localized in rat brain by immunocytochemistry. Calpain I-like immunoreactivity (CLI) was prominent in several structures in which degeneration is an ongoing feature, e.g. spinal motoneurons, olfactory nerve. Also noteworthy was the presence of CLI in regi...
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| Veröffentlicht in: | Brain research 1985-11, Vol.347 (2), p.399-403 |
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| container_title | Brain research |
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| creator | Siman, Robert Gall, Christine Perlmutter, Lynn S. Christian, Clifford Baudry, Michel Lynch, Gary |
| description | The calcium-activated protease calpain I was localized in rat brain by immunocytochemistry. Calpain I-like immunoreactivity (CLI) was prominent in several structures in which degeneration is an ongoing feature, e.g. spinal motoneurons, olfactory nerve. Also noteworthy was the presence of CLI in regions susceptible to age-related pathologies, e.g. cerebellar Purkinje cells, substantia nigra and subiculum. This distribution suggests that calpain I may be involved with both normal and pathological neuronal degeneration. |
| doi_str_mv | 10.1016/0006-8993(85)90208-2 |
| format | Article |
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Calpain I-like immunoreactivity (CLI) was prominent in several structures in which degeneration is an ongoing feature, e.g. spinal motoneurons, olfactory nerve. Also noteworthy was the presence of CLI in regions susceptible to age-related pathologies, e.g. cerebellar Purkinje cells, substantia nigra and subiculum. This distribution suggests that calpain I may be involved with both normal and pathological neuronal degeneration.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(85)90208-2</identifier><identifier>PMID: 2998556</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>aging ; Animals ; Antibodies, Monoclonal ; Antibody Specificity ; Biological and medical sciences ; Brain - enzymology ; Brain - pathology ; calpain ; Calpain - analysis ; Histocytochemistry ; immunocytochemistry ; Immunoenzyme Techniques ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Motor Neurons - enzymology ; Nerve Degeneration ; Nervous system involvement in other diseases. Miscellaneous ; Neuroglia - enzymology ; Neurology ; neuronal degeneration ; Neurons - enzymology ; Neurons - pathology ; protease ; Rats ; Rats, Inbred Strains ; Spinal Cord - enzymology</subject><ispartof>Brain research, 1985-11, Vol.347 (2), p.399-403</ispartof><rights>1985 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-e97aa2c80138a5738afcd02809ecb742c7d987a38730084b06299f93f80b1db3</citedby><cites>FETCH-LOGICAL-c415t-e97aa2c80138a5738afcd02809ecb742c7d987a38730084b06299f93f80b1db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(85)90208-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8694808$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2998556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siman, Robert</creatorcontrib><creatorcontrib>Gall, Christine</creatorcontrib><creatorcontrib>Perlmutter, Lynn S.</creatorcontrib><creatorcontrib>Christian, Clifford</creatorcontrib><creatorcontrib>Baudry, Michel</creatorcontrib><creatorcontrib>Lynch, Gary</creatorcontrib><title>Distribution of calpain I, an enzyme associated with degenerative activity, in rat brain</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The calcium-activated protease calpain I was localized in rat brain by immunocytochemistry. Calpain I-like immunoreactivity (CLI) was prominent in several structures in which degeneration is an ongoing feature, e.g. spinal motoneurons, olfactory nerve. Also noteworthy was the presence of CLI in regions susceptible to age-related pathologies, e.g. cerebellar Purkinje cells, substantia nigra and subiculum. This distribution suggests that calpain I may be involved with both normal and pathological neuronal degeneration.</description><subject>aging</subject><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Antibody Specificity</subject><subject>Biological and medical sciences</subject><subject>Brain - enzymology</subject><subject>Brain - pathology</subject><subject>calpain</subject><subject>Calpain - analysis</subject><subject>Histocytochemistry</subject><subject>immunocytochemistry</subject><subject>Immunoenzyme Techniques</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Motor Neurons - enzymology</subject><subject>Nerve Degeneration</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neuroglia - enzymology</subject><subject>Neurology</subject><subject>neuronal degeneration</subject><subject>Neurons - enzymology</subject><subject>Neurons - pathology</subject><subject>protease</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Spinal Cord - enzymology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEQx4MoWh_fQCEHEQVXZ5PdTXIRpD6h4MWDt5DNzmqk3a1JWqmf3tSWHr1kyPwfDD9CjnO4yiGvrgGgyqRS_FyWFwoYyIxtkUEuBcsqVsA2GWwse2Q_hM_05VzBLtllSsmyrAbk7c6F6F09i67vaN9Sa8ZT4zr6fElNR7H7WUyQmhB660zEhn67-EEbfMcOvYlunkSbhouLS5piaUdrnwoOyU5rxgGP1vOAvD7cvw6fstHL4_PwdpTZIi9jhkoYw6yEnEtTivS0tgEmQaGtRcGsaJQUhkvBAWRRQ5VObxVvJdR5U_MDcraqnfr-a4Yh6okLFsdj02E_C1pURcWZKJOxWBmt70Pw2OqpdxPjFzoHveSpl7D0EpaWpf7jqVmKnaz7Z_UEm01oDTDpp2vdhISu9aazLmxsslKFBJlsNysbJhRzh14H67Cz2DiPNuqmd__f8QsjbpC5</recordid><startdate>19851118</startdate><enddate>19851118</enddate><creator>Siman, Robert</creator><creator>Gall, Christine</creator><creator>Perlmutter, Lynn S.</creator><creator>Christian, Clifford</creator><creator>Baudry, Michel</creator><creator>Lynch, Gary</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19851118</creationdate><title>Distribution of calpain I, an enzyme associated with degenerative activity, in rat brain</title><author>Siman, Robert ; Gall, Christine ; Perlmutter, Lynn S. ; Christian, Clifford ; Baudry, Michel ; Lynch, Gary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-e97aa2c80138a5738afcd02809ecb742c7d987a38730084b06299f93f80b1db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>aging</topic><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Antibody Specificity</topic><topic>Biological and medical sciences</topic><topic>Brain - enzymology</topic><topic>Brain - pathology</topic><topic>calpain</topic><topic>Calpain - analysis</topic><topic>Histocytochemistry</topic><topic>immunocytochemistry</topic><topic>Immunoenzyme Techniques</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Motor Neurons - enzymology</topic><topic>Nerve Degeneration</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neuroglia - enzymology</topic><topic>Neurology</topic><topic>neuronal degeneration</topic><topic>Neurons - enzymology</topic><topic>Neurons - pathology</topic><topic>protease</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Spinal Cord - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siman, Robert</creatorcontrib><creatorcontrib>Gall, Christine</creatorcontrib><creatorcontrib>Perlmutter, Lynn S.</creatorcontrib><creatorcontrib>Christian, Clifford</creatorcontrib><creatorcontrib>Baudry, Michel</creatorcontrib><creatorcontrib>Lynch, Gary</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siman, Robert</au><au>Gall, Christine</au><au>Perlmutter, Lynn S.</au><au>Christian, Clifford</au><au>Baudry, Michel</au><au>Lynch, Gary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of calpain I, an enzyme associated with degenerative activity, in rat brain</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1985-11-18</date><risdate>1985</risdate><volume>347</volume><issue>2</issue><spage>399</spage><epage>403</epage><pages>399-403</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The calcium-activated protease calpain I was localized in rat brain by immunocytochemistry. Calpain I-like immunoreactivity (CLI) was prominent in several structures in which degeneration is an ongoing feature, e.g. spinal motoneurons, olfactory nerve. Also noteworthy was the presence of CLI in regions susceptible to age-related pathologies, e.g. cerebellar Purkinje cells, substantia nigra and subiculum. This distribution suggests that calpain I may be involved with both normal and pathological neuronal degeneration.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2998556</pmid><doi>10.1016/0006-8993(85)90208-2</doi><tpages>5</tpages></addata></record> |
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| ispartof | Brain research, 1985-11, Vol.347 (2), p.399-403 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | aging Animals Antibodies, Monoclonal Antibody Specificity Biological and medical sciences Brain - enzymology Brain - pathology calpain Calpain - analysis Histocytochemistry immunocytochemistry Immunoenzyme Techniques Medical sciences Mice Mice, Inbred BALB C Motor Neurons - enzymology Nerve Degeneration Nervous system involvement in other diseases. Miscellaneous Neuroglia - enzymology Neurology neuronal degeneration Neurons - enzymology Neurons - pathology protease Rats Rats, Inbred Strains Spinal Cord - enzymology |
| title | Distribution of calpain I, an enzyme associated with degenerative activity, in rat brain |
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