Cooperative Interaction Between Ets and AP-1 Transcription Factors Regulates Induction of Glutathione S-Transferase Ya Gene Expression
Induction of mouse glutathione S-transferase (GST) Ya gene expression by a variety of chemical agents is mediated by a regulatory element, EpRE, composed of an Ets and two adjacent AP-1-like binding sites. In this report we present evidence that the basal and inducible activity of EpRE is mediated b...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1994-04, Vol.200 (1), p.290-297 |
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| creator | Bergelson, S. Daniel, V. |
| description | Induction of mouse glutathione S-transferase (GST) Ya gene expression by a variety of chemical agents is mediated by a regulatory element, EpRE, composed of an Ets and two adjacent AP-1-like binding sites. In this report we present evidence that the basal and inducible activity of EpRE is mediated by AP-1 transcription factor and that the cooperative interaction between AP-1 and an Ets protein contributes to enhance the EpRE inducibility. We also show that EpRE, similar to a single AP-1 site, when ligated to GST Ya gene promoter, is transactivated by c-Fos/c-Jun or c-Fos/Jun-B heterodimer and that c-Jun/c-Jun homodimer is an activator of an AP-1 site only in the context of collagenase gene promoter. |
| doi_str_mv | 10.1006/bbrc.1994.1447 |
| format | Article |
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In this report we present evidence that the basal and inducible activity of EpRE is mediated by AP-1 transcription factor and that the cooperative interaction between AP-1 and an Ets protein contributes to enhance the EpRE inducibility. We also show that EpRE, similar to a single AP-1 site, when ligated to GST Ya gene promoter, is transactivated by c-Fos/c-Jun or c-Fos/Jun-B heterodimer and that c-Jun/c-Jun homodimer is an activator of an AP-1 site only in the context of collagenase gene promoter.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1006/bbrc.1994.1447</identifier><identifier>PMID: 8166697</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Base Sequence ; Binding Sites ; Biological and medical sciences ; Cells, Cultured ; DNA - metabolism ; Enhancer Elements, Genetic ; Enzyme Induction ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Glutathione Transferase - biosynthesis ; Glutathione Transferase - genetics ; Mice ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Nuclear Proteins - isolation & purification ; Nuclear Proteins - metabolism ; Oligodeoxyribonucleotides ; Proto-Oncogene Proteins - isolation & purification ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins c-ets ; Proto-Oncogene Proteins c-jun - isolation & purification ; Proto-Oncogene Proteins c-jun - metabolism ; Transcription Factors - metabolism ; Transcription. Transcription factor. Splicing. 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In this report we present evidence that the basal and inducible activity of EpRE is mediated by AP-1 transcription factor and that the cooperative interaction between AP-1 and an Ets protein contributes to enhance the EpRE inducibility. We also show that EpRE, similar to a single AP-1 site, when ligated to GST Ya gene promoter, is transactivated by c-Fos/c-Jun or c-Fos/Jun-B heterodimer and that c-Jun/c-Jun homodimer is an activator of an AP-1 site only in the context of collagenase gene promoter.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>DNA - metabolism</subject><subject>Enhancer Elements, Genetic</subject><subject>Enzyme Induction</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Glutathione Transferase - biosynthesis</subject><subject>Glutathione Transferase - genetics</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Nuclear Proteins - isolation & purification</subject><subject>Nuclear Proteins - metabolism</subject><subject>Oligodeoxyribonucleotides</subject><subject>Proto-Oncogene Proteins - isolation & purification</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-ets</subject><subject>Proto-Oncogene Proteins c-jun - isolation & purification</subject><subject>Proto-Oncogene Proteins c-jun - metabolism</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription. Transcription factor. Splicing. Rna processing</subject><subject>Transfection</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1u1DAURi0EKkNhyw7JC9RdBl_HceJlGU2HSpVAUCRYWY59A0aZONhOgRfgufF0Rt2x8s8936erQ8hLYGtgTL7p-2jXoJRYgxDtI7ICpljFgYnHZMUKUXEFX56SZyn9YAxASHVGzjqQUqp2Rf5uQpgxmuzvkF5PuVxt9mGibzH_QpzoNidqJkcvP1RAb6OZko1-vkeuChpioh_x2zKajKkUuOUYDwPdjUs2-Xt5If1U3UeHUp-QfjV0h-V3-3uOmFIhnpMngxkTvjid5-Tz1fZ28666eb-73lzeVLaWXa7A8l41Pees47LlPTadqo1s6hpaEI4J67CR1g3SilZ1xjrTDLWTojPgRF_X5-Ti2DvH8HPBlPXeJ4vjaCYMS9KtFJKD4AVcH0EbQ0oRBz1HvzfxjwamD-L1Qbw-iNcH8SXw6tS89Ht0D_jJdJm_Ps1NsmYcig7r0wMmWCs6EAXrjhgWC3ceo07W42TR-Yg2axf8_zb4B1P3oDQ</recordid><startdate>19940415</startdate><enddate>19940415</enddate><creator>Bergelson, S.</creator><creator>Daniel, V.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940415</creationdate><title>Cooperative Interaction Between Ets and AP-1 Transcription Factors Regulates Induction of Glutathione S-Transferase Ya Gene Expression</title><author>Bergelson, S. ; Daniel, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-1c2b95b22082672be5893a65331714d04cde56cdf6c4798acda5f3d648a1d4b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>DNA - metabolism</topic><topic>Enhancer Elements, Genetic</topic><topic>Enzyme Induction</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Glutathione Transferase - biosynthesis</topic><topic>Glutathione Transferase - genetics</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Nuclear Proteins - isolation & purification</topic><topic>Nuclear Proteins - metabolism</topic><topic>Oligodeoxyribonucleotides</topic><topic>Proto-Oncogene Proteins - isolation & purification</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-ets</topic><topic>Proto-Oncogene Proteins c-jun - isolation & purification</topic><topic>Proto-Oncogene Proteins c-jun - metabolism</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription. Transcription factor. Splicing. Rna processing</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bergelson, S.</creatorcontrib><creatorcontrib>Daniel, V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bergelson, S.</au><au>Daniel, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cooperative Interaction Between Ets and AP-1 Transcription Factors Regulates Induction of Glutathione S-Transferase Ya Gene Expression</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1994-04-15</date><risdate>1994</risdate><volume>200</volume><issue>1</issue><spage>290</spage><epage>297</epage><pages>290-297</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>Induction of mouse glutathione S-transferase (GST) Ya gene expression by a variety of chemical agents is mediated by a regulatory element, EpRE, composed of an Ets and two adjacent AP-1-like binding sites. In this report we present evidence that the basal and inducible activity of EpRE is mediated by AP-1 transcription factor and that the cooperative interaction between AP-1 and an Ets protein contributes to enhance the EpRE inducibility. We also show that EpRE, similar to a single AP-1 site, when ligated to GST Ya gene promoter, is transactivated by c-Fos/c-Jun or c-Fos/Jun-B heterodimer and that c-Jun/c-Jun homodimer is an activator of an AP-1 site only in the context of collagenase gene promoter.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8166697</pmid><doi>10.1006/bbrc.1994.1447</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1994-04, Vol.200 (1), p.290-297 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Base Sequence Binding Sites Biological and medical sciences Cells, Cultured DNA - metabolism Enhancer Elements, Genetic Enzyme Induction Fundamental and applied biological sciences. Psychology Gene Expression Glutathione Transferase - biosynthesis Glutathione Transferase - genetics Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data Nuclear Proteins - isolation & purification Nuclear Proteins - metabolism Oligodeoxyribonucleotides Proto-Oncogene Proteins - isolation & purification Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-ets Proto-Oncogene Proteins c-jun - isolation & purification Proto-Oncogene Proteins c-jun - metabolism Transcription Factors - metabolism Transcription. Transcription factor. Splicing. Rna processing Transfection |
| title | Cooperative Interaction Between Ets and AP-1 Transcription Factors Regulates Induction of Glutathione S-Transferase Ya Gene Expression |
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