Effects of felodipine versus nifedipine on exercise tolerance in stable angina pectoris
The effects of single doses of felodipine (5 and 10 mg) and nifedipine (10 and 20 mg) on chronic stable effort angina pectoris were assessed in a placebo-controlled, double-blind, crossover study of 24 patients receiving β blockers and short-acting nitroglycerin. The effects were measured by repeate...
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| Veröffentlicht in: | The American journal of cardiology 1994-04, Vol.73 (9), p.658-660 |
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| container_title | The American journal of cardiology |
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| creator | Ekelund, Lars G. Ulvenstam, Göran Walldius, Göran Aberg, Anders |
| description | The effects of single doses of felodipine (5 and 10 mg) and nifedipine (10 and 20 mg) on chronic stable effort angina pectoris were assessed in a placebo-controlled, double-blind, crossover study of 24 patients receiving β blockers and short-acting nitroglycerin. The effects were measured by repeated bicycle ergometer tests. The total work, and time until 1 mm of ST depression increased significantly by 9 to 31% after both active drugs at both dose levels in comparison with placebo. The differences were not significant between drugs or doses. At rest, blood pressure decreased (10 to 15%) and heart rate increased (5 to 10%) significantly after both active drugs. During exercise at the highest comparable work load, systolic blood pressure decreased significantly (23 to 26%), whereas heart rate was not affected after felodipine and nifedipine compared with placebo. The 2 drugs were well tolerated, and side effects were mild. Therefore, single doses of 5 and 10 mg of felodipine, and 10 and 20 mg of nifedipine have similar antiangnal and anti-ischemic properties. However, felodipine has a longer duration of action, which may improve compliance. |
| doi_str_mv | 10.1016/0002-9149(94)90929-6 |
| format | Article |
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The effects were measured by repeated bicycle ergometer tests. The total work, and time until 1 mm of ST depression increased significantly by 9 to 31% after both active drugs at both dose levels in comparison with placebo. The differences were not significant between drugs or doses. At rest, blood pressure decreased (10 to 15%) and heart rate increased (5 to 10%) significantly after both active drugs. During exercise at the highest comparable work load, systolic blood pressure decreased significantly (23 to 26%), whereas heart rate was not affected after felodipine and nifedipine compared with placebo. The 2 drugs were well tolerated, and side effects were mild. Therefore, single doses of 5 and 10 mg of felodipine, and 10 and 20 mg of nifedipine have similar antiangnal and anti-ischemic properties. However, felodipine has a longer duration of action, which may improve compliance.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/0002-9149(94)90929-6</identifier><identifier>PMID: 8166061</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Analysis of Variance ; Angina pectoris ; Angina Pectoris - drug therapy ; Angina Pectoris - physiopathology ; Antianginal agents. Coronary vasodilator agents ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiovascular system ; Double-Blind Method ; Drugs ; Exercise - physiology ; Felodipine - pharmacology ; Felodipine - therapeutic use ; Female ; Heart Rate - drug effects ; Humans ; Male ; Medical research ; Medical sciences ; Middle Aged ; Nifedipine - pharmacology ; Nifedipine - therapeutic use ; Patients ; Pharmacology. 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The effects were measured by repeated bicycle ergometer tests. The total work, and time until 1 mm of ST depression increased significantly by 9 to 31% after both active drugs at both dose levels in comparison with placebo. The differences were not significant between drugs or doses. At rest, blood pressure decreased (10 to 15%) and heart rate increased (5 to 10%) significantly after both active drugs. During exercise at the highest comparable work load, systolic blood pressure decreased significantly (23 to 26%), whereas heart rate was not affected after felodipine and nifedipine compared with placebo. The 2 drugs were well tolerated, and side effects were mild. Therefore, single doses of 5 and 10 mg of felodipine, and 10 and 20 mg of nifedipine have similar antiangnal and anti-ischemic properties. However, felodipine has a longer duration of action, which may improve compliance.</description><subject>Analysis of Variance</subject><subject>Angina pectoris</subject><subject>Angina Pectoris - drug therapy</subject><subject>Angina Pectoris - physiopathology</subject><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular system</subject><subject>Double-Blind Method</subject><subject>Drugs</subject><subject>Exercise - physiology</subject><subject>Felodipine - pharmacology</subject><subject>Felodipine - therapeutic use</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nifedipine - pharmacology</subject><subject>Nifedipine - therapeutic use</subject><subject>Patients</subject><subject>Pharmacology. Drug treatments</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1rFDEUhoMo7Xb1HygEkaIXo_maTHIjlFK1UPCm4mXIZs5IymyyzZkp9d832x32wguvwsl5zsvLQ8hbzj5zxvUXxphoLFf2o1WfLLPCNvoFWXHT2YZbLl-S1RE5JWeId3XkvNUn5MRwrZnmK_L7ahggTEjzQAcYcx93MQF9gIIz0hQHWH5yovAIJUQEOuURik8BaEwUJ78Zgfr0JyZPdzUsl4ivyavBjwhvlndNfn27ur380dz8_H59eXHTBMXl1AgQvu3BBNkazkEFE0xrNZfGmq43wrMgZO3A2tBvWBc2bdsJFZQSgts-KLkm54fcXcn3M-DkthEDjKNPkGd0nVaadaat4Pt_wLs8l1S7OSGZVErWQmuiDlAoGbHA4HYlbn356zhze-lub9TtjTqr3LN0p-vZuyV73myhPx4tluv-w7L3GPw47N1FPGKKGaG0rNjXAwZV2EOE4jBEqJr7WKpW1-f4_x5PACycsg</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>Ekelund, Lars G.</creator><creator>Ulvenstam, Göran</creator><creator>Walldius, Göran</creator><creator>Aberg, Anders</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19940401</creationdate><title>Effects of felodipine versus nifedipine on exercise tolerance in stable angina pectoris</title><author>Ekelund, Lars G. ; Ulvenstam, Göran ; Walldius, Göran ; Aberg, Anders</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-2e2a5de8c35811e4c8c8596138987d82a0c23fed05cdb07cb55724c442219dc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Analysis of Variance</topic><topic>Angina pectoris</topic><topic>Angina Pectoris - drug therapy</topic><topic>Angina Pectoris - physiopathology</topic><topic>Antianginal agents. Coronary vasodilator agents</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular system</topic><topic>Double-Blind Method</topic><topic>Drugs</topic><topic>Exercise - physiology</topic><topic>Felodipine - pharmacology</topic><topic>Felodipine - therapeutic use</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nifedipine - pharmacology</topic><topic>Nifedipine - therapeutic use</topic><topic>Patients</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ekelund, Lars G.</creatorcontrib><creatorcontrib>Ulvenstam, Göran</creatorcontrib><creatorcontrib>Walldius, Göran</creatorcontrib><creatorcontrib>Aberg, Anders</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ekelund, Lars G.</au><au>Ulvenstam, Göran</au><au>Walldius, Göran</au><au>Aberg, Anders</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of felodipine versus nifedipine on exercise tolerance in stable angina pectoris</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>73</volume><issue>9</issue><spage>658</spage><epage>660</epage><pages>658-660</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>The effects of single doses of felodipine (5 and 10 mg) and nifedipine (10 and 20 mg) on chronic stable effort angina pectoris were assessed in a placebo-controlled, double-blind, crossover study of 24 patients receiving β blockers and short-acting nitroglycerin. The effects were measured by repeated bicycle ergometer tests. The total work, and time until 1 mm of ST depression increased significantly by 9 to 31% after both active drugs at both dose levels in comparison with placebo. The differences were not significant between drugs or doses. At rest, blood pressure decreased (10 to 15%) and heart rate increased (5 to 10%) significantly after both active drugs. During exercise at the highest comparable work load, systolic blood pressure decreased significantly (23 to 26%), whereas heart rate was not affected after felodipine and nifedipine compared with placebo. The 2 drugs were well tolerated, and side effects were mild. Therefore, single doses of 5 and 10 mg of felodipine, and 10 and 20 mg of nifedipine have similar antiangnal and anti-ischemic properties. However, felodipine has a longer duration of action, which may improve compliance.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8166061</pmid><doi>10.1016/0002-9149(94)90929-6</doi><tpages>3</tpages></addata></record> |
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| ispartof | The American journal of cardiology, 1994-04, Vol.73 (9), p.658-660 |
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| subjects | Analysis of Variance Angina pectoris Angina Pectoris - drug therapy Angina Pectoris - physiopathology Antianginal agents. Coronary vasodilator agents Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Double-Blind Method Drugs Exercise - physiology Felodipine - pharmacology Felodipine - therapeutic use Female Heart Rate - drug effects Humans Male Medical research Medical sciences Middle Aged Nifedipine - pharmacology Nifedipine - therapeutic use Patients Pharmacology. Drug treatments |
| title | Effects of felodipine versus nifedipine on exercise tolerance in stable angina pectoris |
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