Internalization and degradation of monoclonal antibody chCE7 by human neuroblastoma cells

Internalization and cellular degradation of a chimeric monoclonal anti‐neuroblastoma antibody (MAb chCE7) is described. Immunofluorescence localization showed temperature‐dependent redistribution of MAb chCE7 from the cell surface at O°C to vesicular structures after heating to 37°C. SKN‐AS cells wh...

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Veröffentlicht in:	International journal of cancer 1994-05, Vol.57 (3), p.427-432
Hauptverfasser:	Novak‐Hofer, Ilse, Amstutz, Hans Peter, Morgenthaler, Jean‐Jacques, Schubiger, P. August
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - metabolism Antigens, Neoplasm - metabolism Biological and medical sciences Diseases of the nervous system Fluorescent Antibody Technique Humans Iodine Radioisotopes - metabolism Medical sciences Neuroblastoma - immunology Neuroblastoma - metabolism Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Temperature
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