Effect of aprotinin on fibrinopurulent peritonitis in rats
The effect of aprotinin on the clinical and pathologic course of experimentally induced peritonitis in the rat was studied. Peritonitis was induced in 40 rats by creating a closed ileal loop 4 cm long 5 cm from the ileocecal valve. The rats were divided into two groups of 20 rats each. Group 1 serve...
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| Veröffentlicht in: | The American journal of surgery 1985-11, Vol.150 (5), p.550-553 |
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| creator | Chalkiadakis, George E. Kostakis, Alkis Karydakis, Periklis Chalkiadakis, Mary E. Matsikas, Pantelis Karayannoccos, Panayotis E. Sechas, Michael Skalkeas, Gregory D. |
| description | The effect of aprotinin on the clinical and pathologic course of experimentally induced peritonitis in the rat was studied. Peritonitis was induced in 40 rats by creating a closed ileal loop 4 cm long 5 cm from the ileocecal valve. The rats were divided into two groups of 20 rats each. Group 1 served as a control group, whereas each animal in Group 2 received a bolus dose of aprotinin (10 ml) intraperitoneally immediately after closing the laparotomy. In the aprotinin-treated group, survival was drastically increased (p < 0.01) and formation of adhesions and abscesses was considerably reduced. The results of peritoneal cultures showed a decreased incidence of Escherichia coli and Clostridia in the aprotinin-treated group.
We conclude that the administration of aprotinin significantly prolongs the survival time of animals with peritonitis and reduces the development of adhesions and abscesses in the peritoneal cavity. This beneficial effect can be attributed to decreased fibrinogen deposits within the peritoneal cavity and the stabilization of the organism after bacterial shock. Thus, bacteria were more susceptible to cellular and noncellular clearing mechanisms. |
| doi_str_mv | 10.1016/0002-9610(85)90434-9 |
| format | Article |
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We conclude that the administration of aprotinin significantly prolongs the survival time of animals with peritonitis and reduces the development of adhesions and abscesses in the peritoneal cavity. This beneficial effect can be attributed to decreased fibrinogen deposits within the peritoneal cavity and the stabilization of the organism after bacterial shock. Thus, bacteria were more susceptible to cellular and noncellular clearing mechanisms.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/0002-9610(85)90434-9</identifier><identifier>PMID: 2415011</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject><![CDATA[Abscess - physiopathology ; Abscess - prevention & control ; Animals ; Aprotinin - pharmacology ; Biological and medical sciences ; Clostridium Infections - physiopathology ; Clostridium Infections - prevention & control ; Digestive system ; Escherichia coli Infections - physiopathology ; Escherichia coli Infections - prevention & control ; Female ; Fibrin - physiology ; Male ; Medical sciences ; Peritonitis - mortality ; Peritonitis - physiopathology ; Peritonitis - prevention & control ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Surgical Wound Infection - physiopathology ; Surgical Wound Infection - prevention & control ; Tissue Adhesions - physiopathology ; Tissue Adhesions - prevention & control]]></subject><ispartof>The American journal of surgery, 1985-11, Vol.150 (5), p.550-553</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-f9f029fd601a49849b25b646494a4d2b96f91040e19b2c867075480e988aff003</citedby><cites>FETCH-LOGICAL-c386t-f9f029fd601a49849b25b646494a4d2b96f91040e19b2c867075480e988aff003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9610(85)90434-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8775835$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2415011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chalkiadakis, George E.</creatorcontrib><creatorcontrib>Kostakis, Alkis</creatorcontrib><creatorcontrib>Karydakis, Periklis</creatorcontrib><creatorcontrib>Chalkiadakis, Mary E.</creatorcontrib><creatorcontrib>Matsikas, Pantelis</creatorcontrib><creatorcontrib>Karayannoccos, Panayotis E.</creatorcontrib><creatorcontrib>Sechas, Michael</creatorcontrib><creatorcontrib>Skalkeas, Gregory D.</creatorcontrib><title>Effect of aprotinin on fibrinopurulent peritonitis in rats</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>The effect of aprotinin on the clinical and pathologic course of experimentally induced peritonitis in the rat was studied. Peritonitis was induced in 40 rats by creating a closed ileal loop 4 cm long 5 cm from the ileocecal valve. The rats were divided into two groups of 20 rats each. Group 1 served as a control group, whereas each animal in Group 2 received a bolus dose of aprotinin (10 ml) intraperitoneally immediately after closing the laparotomy. In the aprotinin-treated group, survival was drastically increased (p < 0.01) and formation of adhesions and abscesses was considerably reduced. The results of peritoneal cultures showed a decreased incidence of Escherichia coli and Clostridia in the aprotinin-treated group.
We conclude that the administration of aprotinin significantly prolongs the survival time of animals with peritonitis and reduces the development of adhesions and abscesses in the peritoneal cavity. This beneficial effect can be attributed to decreased fibrinogen deposits within the peritoneal cavity and the stabilization of the organism after bacterial shock. Thus, bacteria were more susceptible to cellular and noncellular clearing mechanisms.</description><subject>Abscess - physiopathology</subject><subject>Abscess - prevention & control</subject><subject>Animals</subject><subject>Aprotinin - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Clostridium Infections - physiopathology</subject><subject>Clostridium Infections - prevention & control</subject><subject>Digestive system</subject><subject>Escherichia coli Infections - physiopathology</subject><subject>Escherichia coli Infections - prevention & control</subject><subject>Female</subject><subject>Fibrin - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Peritonitis - mortality</subject><subject>Peritonitis - physiopathology</subject><subject>Peritonitis - prevention & control</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Surgical Wound Infection - physiopathology</subject><subject>Surgical Wound Infection - prevention & control</subject><subject>Tissue Adhesions - physiopathology</subject><subject>Tissue Adhesions - prevention & control</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxR6ENFDNWmTNPEgyLJ-wIIXPYc0TSDSTdYkFfz3pm7Zo6fJ8D4zGR4AzhG8RRDROwhhVXKK4DUjNxziGpf8AMwRa3iJGKsPwXyPHIOTGD9zixCuZ2BWYUTyew7uV8ZolQpvCrkNPllnXeFdYWwbrPPbIQy9dqnY6mCTdzbZWGQiyBRPwZGRfdRnU12Aj6fV-_KlXL89vy4f16WqGU2l4QZW3HQUIok5w7ytSEsxxRxL3FUtp4YjiKFGOVGMNrAhmEHNGZPGQFgvwNVub77va9AxiY2NSve9dNoPUTQUE0oakkG8A1XwMQZtxDbYjQw_AkExKhOjDzH6EIyIP2WC57GLaf_QbnS3H5oc5fxyymVUsjdBOmXjHmNNQ1g9_v6ww3R28W11EFFZ7ZTubMiGReft_3f8AmeHhcU</recordid><startdate>198511</startdate><enddate>198511</enddate><creator>Chalkiadakis, George E.</creator><creator>Kostakis, Alkis</creator><creator>Karydakis, Periklis</creator><creator>Chalkiadakis, Mary E.</creator><creator>Matsikas, Pantelis</creator><creator>Karayannoccos, Panayotis E.</creator><creator>Sechas, Michael</creator><creator>Skalkeas, Gregory D.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198511</creationdate><title>Effect of aprotinin on fibrinopurulent peritonitis in rats</title><author>Chalkiadakis, George E. ; Kostakis, Alkis ; Karydakis, Periklis ; Chalkiadakis, Mary E. ; Matsikas, Pantelis ; Karayannoccos, Panayotis E. ; Sechas, Michael ; Skalkeas, Gregory D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-f9f029fd601a49849b25b646494a4d2b96f91040e19b2c867075480e988aff003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Abscess - physiopathology</topic><topic>Abscess - prevention & control</topic><topic>Animals</topic><topic>Aprotinin - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Clostridium Infections - physiopathology</topic><topic>Clostridium Infections - prevention & control</topic><topic>Digestive system</topic><topic>Escherichia coli Infections - physiopathology</topic><topic>Escherichia coli Infections - prevention & control</topic><topic>Female</topic><topic>Fibrin - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Peritonitis - mortality</topic><topic>Peritonitis - physiopathology</topic><topic>Peritonitis - prevention & control</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Surgical Wound Infection - physiopathology</topic><topic>Surgical Wound Infection - prevention & control</topic><topic>Tissue Adhesions - physiopathology</topic><topic>Tissue Adhesions - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chalkiadakis, George E.</creatorcontrib><creatorcontrib>Kostakis, Alkis</creatorcontrib><creatorcontrib>Karydakis, Periklis</creatorcontrib><creatorcontrib>Chalkiadakis, Mary E.</creatorcontrib><creatorcontrib>Matsikas, Pantelis</creatorcontrib><creatorcontrib>Karayannoccos, Panayotis E.</creatorcontrib><creatorcontrib>Sechas, Michael</creatorcontrib><creatorcontrib>Skalkeas, Gregory D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chalkiadakis, George E.</au><au>Kostakis, Alkis</au><au>Karydakis, Periklis</au><au>Chalkiadakis, Mary E.</au><au>Matsikas, Pantelis</au><au>Karayannoccos, Panayotis E.</au><au>Sechas, Michael</au><au>Skalkeas, Gregory D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of aprotinin on fibrinopurulent peritonitis in rats</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1985-11</date><risdate>1985</risdate><volume>150</volume><issue>5</issue><spage>550</spage><epage>553</epage><pages>550-553</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>The effect of aprotinin on the clinical and pathologic course of experimentally induced peritonitis in the rat was studied. Peritonitis was induced in 40 rats by creating a closed ileal loop 4 cm long 5 cm from the ileocecal valve. The rats were divided into two groups of 20 rats each. Group 1 served as a control group, whereas each animal in Group 2 received a bolus dose of aprotinin (10 ml) intraperitoneally immediately after closing the laparotomy. In the aprotinin-treated group, survival was drastically increased (p < 0.01) and formation of adhesions and abscesses was considerably reduced. The results of peritoneal cultures showed a decreased incidence of Escherichia coli and Clostridia in the aprotinin-treated group.
We conclude that the administration of aprotinin significantly prolongs the survival time of animals with peritonitis and reduces the development of adhesions and abscesses in the peritoneal cavity. This beneficial effect can be attributed to decreased fibrinogen deposits within the peritoneal cavity and the stabilization of the organism after bacterial shock. Thus, bacteria were more susceptible to cellular and noncellular clearing mechanisms.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2415011</pmid><doi>10.1016/0002-9610(85)90434-9</doi><tpages>4</tpages></addata></record> |
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| subjects | Abscess - physiopathology Abscess - prevention & control Animals Aprotinin - pharmacology Biological and medical sciences Clostridium Infections - physiopathology Clostridium Infections - prevention & control Digestive system Escherichia coli Infections - physiopathology Escherichia coli Infections - prevention & control Female Fibrin - physiology Male Medical sciences Peritonitis - mortality Peritonitis - physiopathology Peritonitis - prevention & control Pharmacology. Drug treatments Rats Rats, Inbred Strains Surgical Wound Infection - physiopathology Surgical Wound Infection - prevention & control Tissue Adhesions - physiopathology Tissue Adhesions - prevention & control |
| title | Effect of aprotinin on fibrinopurulent peritonitis in rats |
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