One-Pot Enantioselective Syntheses of Iminosugar Derivatives Using Organocatalytic anti-Michael−anti-Aza-Henry Reactions

Organocatalyst-controlled asymmetric anti-Michael reactions of (tert-butyldimethylsilyloxy)acetaldehyde with a range of nitroolefins, followed by an intermolecular aza-Henry reaction with imine, provided iminosugar derivatives with five contiguous stereocenters in very high enantiomeric excess in on...

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Veröffentlicht in:	Organic letters 2010-11, Vol.12 (22), p.5250-5253
Hauptverfasser:	Imashiro, Ritsuo, Uehara, Hisatoshi, Barbas, Carlos F
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbohydrate Conformation Catalysis Combinatorial Chemistry Techniques Crystallography, X-Ray Imino Sugars - chemical synthesis Imino Sugars - chemistry Models, Molecular Molecular Structure Nitro Compounds - chemical synthesis Nitro Compounds - chemistry Organosilicon Compounds - chemistry Stereoisomerism
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