Enantioselective Total Synthesis of (−)- and (+)-Petrosin

The enantioselective total synthesis of (−)- and (+)-petrosin is described. The union of two key segments was executed by Suzuki−Miyaura coupling. The quinolizidine rings were stereoselectively constructed via a diastereoselective Mannich reaction and an aza-Michael reaction. The 16-membered ring wa...

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Veröffentlicht in:	Organic letters 2010-11, Vol.12 (22), p.5196-5199
Hauptverfasser:	Toya, Hiroki, Okano, Kentaro, Takasu, Kiyosei, Ihara, Masataka, Takahashi, Atsushi, Tanaka, Haruo, Tokuyama, Hidetoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemical synthesis Alkaloids - chemistry Animals Catalysis Cyclization Marine Biology Molecular Structure Petrosia - chemistry Quinolizidines - chemical synthesis Quinolizidines - chemistry Stereoisomerism
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