C−H Bond Functionalization in the Synthesis of Fused 1,2,3-Triazoles

C−H Bond Functionalization in the Synthesis of Fused 1,2,3-Triazoles

A highly modular approach to fused 1,2,3-triazoles has been developed featuring a one-pot procedure combining copper(I) catalyzed azide−alkyne cycloaddition and palladium-catalyzed C−H bond functionalization. A class of structurally unique heterocycles was synthesized in good yields.

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Veröffentlicht in:Organic letters 2010-11, Vol.12 (22), p.5092-5095
Hauptverfasser: Panteleev, Jane, Geyer, Karolin, Aguilar-Aguilar, Angelica, Wang, Letian, Lautens, Mark
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Azides - chemistry
Catalysis
Combinatorial Chemistry Techniques
Copper - chemistry
Cyclization
Heterocyclic Compounds, 4 or More Rings - chemical synthesis
Heterocyclic Compounds, 4 or More Rings - chemistry
Molecular Structure
Palladium - chemistry
Triazoles - chemical synthesis
Triazoles - chemistry
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Zusammenfassung:A highly modular approach to fused 1,2,3-triazoles has been developed featuring a one-pot procedure combining copper(I) catalyzed azide−alkyne cycloaddition and palladium-catalyzed C−H bond functionalization. A class of structurally unique heterocycles was synthesized in good yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol102342y