Noncovalent DNA-Binding Metallo-Supramolecular Cylinders Prevent DNA Transactions in vitro
Supramolecular metal cylinders not only bind noncovalently to DNA inducing substantial coiling but are able to recognize specific DNA structures involved in biological processes as DNA replication. It is demonstrated that these molecules can inhibit the amplification of the DNA mediated by a Taq DNA...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2010-11, Vol.49 (47), p.8942-8945 |
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| container_issue | 47 |
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| container_title | Angewandte Chemie International Edition |
| container_volume | 49 |
| creator | Ducani, Cosimo Leczkowska, Anna Hodges, Nikolas J. Hannon, Michael J. |
| description | Supramolecular metal cylinders not only bind noncovalently to DNA inducing substantial coiling but are able to recognize specific DNA structures involved in biological processes as DNA replication. It is demonstrated that these molecules can inhibit the amplification of the DNA mediated by a Taq DNA polymerase and are even able to displace the enzyme from a double strand DNA (see scheme). |
| doi_str_mv | 10.1002/anie.201004471 |
| format | Article |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | cancer Coordination Complexes - chemistry Coordination Complexes - therapeutic use DNA - chemistry DNA Replication - drug effects helical structures Humans Iron - chemistry Ligands metallodrugs Neoplasms - drug therapy PCR inhibition Ruthenium - chemistry supramolecular chemistry Taq Polymerase - metabolism |
| title | Noncovalent DNA-Binding Metallo-Supramolecular Cylinders Prevent DNA Transactions in vitro |
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