Natural History of Cervical Infection with Human Papillomaviruses

Human papillomavirus (HPV) is a sexually transmitted virus that has been studied primarily in the context of its role as an epidemiological risk factor for cervical cancer and as a biological agent capable of modifying cellular growth and differentiation. Chronic cervical HPV infection appears to be...

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Veröffentlicht in:Clinical infectious diseases 1994-02, Vol.18 (2), p.172-180
1. Verfasser: Morrison, E A
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creator Morrison, E A
description Human papillomavirus (HPV) is a sexually transmitted virus that has been studied primarily in the context of its role as an epidemiological risk factor for cervical cancer and as a biological agent capable of modifying cellular growth and differentiation. Chronic cervical HPV infection appears to be etiologically linked to neoplastic changes of the cervix. However, it has recently become apparent that HPV is highly prevalent in the general population, including a substantial number of cytologically normal women. Although HPV detection is often transient in these individuals, it is not known whether the virus is truly eliminated or whether it remains below the threshold of detection in a latent state. Little is known about the interaction between HPV and other risk factors for cervical cancer, but it is possible that variables such as pregnancy, immunosuppression, and use of oral contraceptives may alter the natural history of HPV infection.
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Chronic cervical HPV infection appears to be etiologically linked to neoplastic changes of the cervix. However, it has recently become apparent that HPV is highly prevalent in the general population, including a substantial number of cytologically normal women. Although HPV detection is often transient in these individuals, it is not known whether the virus is truly eliminated or whether it remains below the threshold of detection in a latent state. 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subjects Cervical cancer
Cervix uteri
Clinical Infectious Disease Articles
Condylomata Acuminata - etiology
Condylomata Acuminata - virology
DNA, Viral - isolation & purification
Female
Genitalia
Humans
Infections
Lesions
Natural history
Neoplasia
Papillomaviridae
Papillomavirus infections
Papillomavirus Infections - etiology
Papillomavirus Infections - transmission
Papillomavirus Infections - virology
Predisposing factors
Risk Factors
Sexual Behavior
Tumor Virus Infections - etiology
Tumor Virus Infections - transmission
Tumor Virus Infections - virology
Uterine Cervical Diseases - etiology
Uterine Cervical Diseases - virology
Uterine Cervical Neoplasms - etiology
Uterine Cervical Neoplasms - virology
Viruses
title Natural History of Cervical Infection with Human Papillomaviruses
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