Natural History of Cervical Infection with Human Papillomaviruses
Human papillomavirus (HPV) is a sexually transmitted virus that has been studied primarily in the context of its role as an epidemiological risk factor for cervical cancer and as a biological agent capable of modifying cellular growth and differentiation. Chronic cervical HPV infection appears to be...
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Veröffentlicht in: | Clinical infectious diseases 1994-02, Vol.18 (2), p.172-180 |
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description | Human papillomavirus (HPV) is a sexually transmitted virus that has been studied primarily in the context of its role as an epidemiological risk factor for cervical cancer and as a biological agent capable of modifying cellular growth and differentiation. Chronic cervical HPV infection appears to be etiologically linked to neoplastic changes of the cervix. However, it has recently become apparent that HPV is highly prevalent in the general population, including a substantial number of cytologically normal women. Although HPV detection is often transient in these individuals, it is not known whether the virus is truly eliminated or whether it remains below the threshold of detection in a latent state. Little is known about the interaction between HPV and other risk factors for cervical cancer, but it is possible that variables such as pregnancy, immunosuppression, and use of oral contraceptives may alter the natural history of HPV infection. |
doi_str_mv | 10.1093/clinids/18.2.172 |
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Chronic cervical HPV infection appears to be etiologically linked to neoplastic changes of the cervix. However, it has recently become apparent that HPV is highly prevalent in the general population, including a substantial number of cytologically normal women. Although HPV detection is often transient in these individuals, it is not known whether the virus is truly eliminated or whether it remains below the threshold of detection in a latent state. Little is known about the interaction between HPV and other risk factors for cervical cancer, but it is possible that variables such as pregnancy, immunosuppression, and use of oral contraceptives may alter the natural history of HPV infection.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/clinids/18.2.172</identifier><identifier>PMID: 8161623</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Cervical cancer ; Cervix uteri ; Clinical Infectious Disease Articles ; Condylomata Acuminata - etiology ; Condylomata Acuminata - virology ; DNA, Viral - isolation & purification ; Female ; Genitalia ; Humans ; Infections ; Lesions ; Natural history ; Neoplasia ; Papillomaviridae ; Papillomavirus infections ; Papillomavirus Infections - etiology ; Papillomavirus Infections - transmission ; Papillomavirus Infections - virology ; Predisposing factors ; Risk Factors ; Sexual Behavior ; Tumor Virus Infections - etiology ; Tumor Virus Infections - transmission ; Tumor Virus Infections - virology ; Uterine Cervical Diseases - etiology ; Uterine Cervical Diseases - virology ; Uterine Cervical Neoplasms - etiology ; Uterine Cervical Neoplasms - virology ; Viruses</subject><ispartof>Clinical infectious diseases, 1994-02, Vol.18 (2), p.172-180</ispartof><rights>Copyright 1994 The University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-79efb9ed429c679b9f363ed722ef5697188b6ad1c96e3b31405fe97bb1a4623c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4457640$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4457640$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8161623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morrison, E A</creatorcontrib><title>Natural History of Cervical Infection with Human Papillomaviruses</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>Human papillomavirus (HPV) is a sexually transmitted virus that has been studied primarily in the context of its role as an epidemiological risk factor for cervical cancer and as a biological agent capable of modifying cellular growth and differentiation. Chronic cervical HPV infection appears to be etiologically linked to neoplastic changes of the cervix. However, it has recently become apparent that HPV is highly prevalent in the general population, including a substantial number of cytologically normal women. Although HPV detection is often transient in these individuals, it is not known whether the virus is truly eliminated or whether it remains below the threshold of detection in a latent state. Little is known about the interaction between HPV and other risk factors for cervical cancer, but it is possible that variables such as pregnancy, immunosuppression, and use of oral contraceptives may alter the natural history of HPV infection.</description><subject>Cervical cancer</subject><subject>Cervix uteri</subject><subject>Clinical Infectious Disease Articles</subject><subject>Condylomata Acuminata - etiology</subject><subject>Condylomata Acuminata - virology</subject><subject>DNA, Viral - isolation & purification</subject><subject>Female</subject><subject>Genitalia</subject><subject>Humans</subject><subject>Infections</subject><subject>Lesions</subject><subject>Natural history</subject><subject>Neoplasia</subject><subject>Papillomaviridae</subject><subject>Papillomavirus infections</subject><subject>Papillomavirus Infections - etiology</subject><subject>Papillomavirus Infections - transmission</subject><subject>Papillomavirus Infections - virology</subject><subject>Predisposing factors</subject><subject>Risk Factors</subject><subject>Sexual Behavior</subject><subject>Tumor Virus Infections - etiology</subject><subject>Tumor Virus Infections - transmission</subject><subject>Tumor Virus Infections - virology</subject><subject>Uterine Cervical Diseases - etiology</subject><subject>Uterine Cervical Diseases - virology</subject><subject>Uterine Cervical Neoplasms - etiology</subject><subject>Uterine Cervical Neoplasms - virology</subject><subject>Viruses</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1PwjAUwBujQUXvHjTZydugXdevIxJxJEQ5aGK4NF3XxeI-sN1Q_ntLIJzey_u9r_wAuENwhKDAY13ZxhZ-jPgoGSGWnIErRDCLKRHoPOSQ8DjlmF-Ca-_XECLEIRmAAUcU0QRfgcmr6nqnqiizvmvdLmrLaGrc1upQmzel0Z1tm-jXdl9R1teqiZZqY6uqrdXWut4bfwMuSlV5c3uMQ_Axe36fZvHi7WU-nSxijQnuYiZMmQtTpInQlIlclJhiU7AkMSWhgiHOc6oKpAU1OMcohaQ0guU5Umn4VOMheDzs3bj2pze-k7X12lSVakzbe8loSjAhMDTCQ6N2rffOlHLjbK3cTiIo99bk0ZpEXCYyWAsjD8fdfV6b4jRw1BT4_YGv95JOOE1JuLq_GB9wcGj-Tli5b0kZZkRmnyspFow9rZaZnOF_dhaCug</recordid><startdate>19940201</startdate><enddate>19940201</enddate><creator>Morrison, E A</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940201</creationdate><title>Natural History of Cervical Infection with Human Papillomaviruses</title><author>Morrison, E A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-79efb9ed429c679b9f363ed722ef5697188b6ad1c96e3b31405fe97bb1a4623c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Cervical cancer</topic><topic>Cervix uteri</topic><topic>Clinical Infectious Disease Articles</topic><topic>Condylomata Acuminata - etiology</topic><topic>Condylomata Acuminata - virology</topic><topic>DNA, Viral - isolation & purification</topic><topic>Female</topic><topic>Genitalia</topic><topic>Humans</topic><topic>Infections</topic><topic>Lesions</topic><topic>Natural history</topic><topic>Neoplasia</topic><topic>Papillomaviridae</topic><topic>Papillomavirus infections</topic><topic>Papillomavirus Infections - etiology</topic><topic>Papillomavirus Infections - transmission</topic><topic>Papillomavirus Infections - virology</topic><topic>Predisposing factors</topic><topic>Risk Factors</topic><topic>Sexual Behavior</topic><topic>Tumor Virus Infections - etiology</topic><topic>Tumor Virus Infections - transmission</topic><topic>Tumor Virus Infections - virology</topic><topic>Uterine Cervical Diseases - etiology</topic><topic>Uterine Cervical Diseases - virology</topic><topic>Uterine Cervical Neoplasms - etiology</topic><topic>Uterine Cervical Neoplasms - virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morrison, E A</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morrison, E A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural History of Cervical Infection with Human Papillomaviruses</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>1994-02-01</date><risdate>1994</risdate><volume>18</volume><issue>2</issue><spage>172</spage><epage>180</epage><pages>172-180</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Human papillomavirus (HPV) is a sexually transmitted virus that has been studied primarily in the context of its role as an epidemiological risk factor for cervical cancer and as a biological agent capable of modifying cellular growth and differentiation. Chronic cervical HPV infection appears to be etiologically linked to neoplastic changes of the cervix. However, it has recently become apparent that HPV is highly prevalent in the general population, including a substantial number of cytologically normal women. Although HPV detection is often transient in these individuals, it is not known whether the virus is truly eliminated or whether it remains below the threshold of detection in a latent state. Little is known about the interaction between HPV and other risk factors for cervical cancer, but it is possible that variables such as pregnancy, immunosuppression, and use of oral contraceptives may alter the natural history of HPV infection.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>8161623</pmid><doi>10.1093/clinids/18.2.172</doi><tpages>9</tpages></addata></record> |
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subjects | Cervical cancer Cervix uteri Clinical Infectious Disease Articles Condylomata Acuminata - etiology Condylomata Acuminata - virology DNA, Viral - isolation & purification Female Genitalia Humans Infections Lesions Natural history Neoplasia Papillomaviridae Papillomavirus infections Papillomavirus Infections - etiology Papillomavirus Infections - transmission Papillomavirus Infections - virology Predisposing factors Risk Factors Sexual Behavior Tumor Virus Infections - etiology Tumor Virus Infections - transmission Tumor Virus Infections - virology Uterine Cervical Diseases - etiology Uterine Cervical Diseases - virology Uterine Cervical Neoplasms - etiology Uterine Cervical Neoplasms - virology Viruses |
title | Natural History of Cervical Infection with Human Papillomaviruses |
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