DNA damage by the glycation products of glyceraldehyde 3-phosphate and lysine

In order to evaluate whether base modifications, apurinic/apyrimidinic site formation, strand breaks, or a combination of these lesions results from the interaction of glycation products with DNA, plasmid DNA was first reacted with these products, and then subjected to digestion with endonuclease II...

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Veröffentlicht in:	Diabetologia 1994-02, Vol.37 (2), p.145-149
Hauptverfasser:	MULLOKANDOV, E. A, FRANKLIN, W. A, BROWNLEE, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Deoxyribonuclease (Pyrimidine Dimer) Deoxyribonuclease IV (Phage T4-Induced) DNA Damage DNA-(Apurinic or Apyrimidinic Site) Lyase Endodeoxyribonucleases - metabolism Escherichia coli - enzymology Escherichia coli Proteins Fundamental and applied biological sciences. Psychology Glycation End Products, Advanced Glyceraldehyde 3-Phosphate Lysine Molecular and cellular biology Molecular genetics Mutagenesis. Repair Plasmids
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