Antagonism of the hypnotic effect of ethanol in mice by an alpha-1 adrenoceptor agonist

A lipid soluble α 1-adrenoceptor agonist 2-(2-chloro-5-trifluoromethylphenylimino) imidazolidine (St 587) antagonized the hypnotic effect of ethanol in C57B1/6 and CD-1 mice. In Swiss-Webster mice the effect of St 587 was weak and in BALB/c mice this drug potentiated ethanol hypnosis. St 587 did not...

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Veröffentlicht in:	Neuropharmacology 1985-01, Vol.24 (9), p.927-930
Hauptverfasser:	Menon, M.K., Kodama, C.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - pharmacology Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Clonidine - analogs & derivatives Clonidine - pharmacology Ethanol - antagonists & inhibitors Ethanol - metabolism Hypnotics and Sedatives - antagonists & inhibitors Imidazoles - pharmacology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Toxicology
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