Diurnal Variations in Cyclic AMP and Melatonin Content of Golden Hamster Retina
: The diurnal variations and photic regulation of cyclic AMP and melatonin content in golden hamster retina were studied. Both parameters showed significant diurnal variations with maximal values at night. Light exposure during the night inhibited retinal cyclic AMP and melatonin levels, whereas exp...
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| Veröffentlicht in: | Journal of neurochemistry 1994-05, Vol.62 (5), p.1995-2000 |
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| container_end_page | 2000 |
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| container_issue | 5 |
| container_start_page | 1995 |
| container_title | Journal of neurochemistry |
| container_volume | 62 |
| creator | Faillace, María P. Sarmiento, María I. Keller Siri, Leonardo Nicola Rosenstein, Ruth E. |
| description | : The diurnal variations and photic regulation of cyclic AMP and melatonin content in golden hamster retina were studied. Both parameters showed significant diurnal variations with maximal values at night. Light exposure during the night inhibited retinal cyclic AMP and melatonin levels, whereas exposure to darkness during the day significantly increased cyclic AMP and melatonin content. Incubation with melatonin of retinas excised at different intervals indicated that the methoxyindole inhibited cyclic AMP accumulation in a time‐dependent manner. The inhibitory effect of melatonin at 2400 h and at noon showed a threshold concentration of 1 and 10 pM, respectively. At 0400 h melatonin did not affect cyclic AMP accumulation. The results indicate a diurnal variability of retinal cyclic AMP and melatonin content in hamsters, mainly influenced by a photic stimulus. Cyclic AMP could be a putative second messenger for melatonin action in golden hamster retina. |
| doi_str_mv | 10.1046/j.1471-4159.1994.62051995.x |
| format | Article |
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Keller ; Siri, Leonardo Nicola ; Rosenstein, Ruth E.</creator><creatorcontrib>Faillace, María P. ; Sarmiento, María I. Keller ; Siri, Leonardo Nicola ; Rosenstein, Ruth E.</creatorcontrib><description>: The diurnal variations and photic regulation of cyclic AMP and melatonin content in golden hamster retina were studied. Both parameters showed significant diurnal variations with maximal values at night. Light exposure during the night inhibited retinal cyclic AMP and melatonin levels, whereas exposure to darkness during the day significantly increased cyclic AMP and melatonin content. Incubation with melatonin of retinas excised at different intervals indicated that the methoxyindole inhibited cyclic AMP accumulation in a time‐dependent manner. The inhibitory effect of melatonin at 2400 h and at noon showed a threshold concentration of 1 and 10 pM, respectively. At 0400 h melatonin did not affect cyclic AMP accumulation. The results indicate a diurnal variability of retinal cyclic AMP and melatonin content in hamsters, mainly influenced by a photic stimulus. Cyclic AMP could be a putative second messenger for melatonin action in golden hamster retina.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1046/j.1471-4159.1994.62051995.x</identifier><identifier>PMID: 8158146</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Biological and medical sciences ; Circadian Rhythm ; Cricetinae ; Cyclic AMP ; Cyclic AMP - metabolism ; Darkness ; Diurnal variations ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. 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Keller</creatorcontrib><creatorcontrib>Siri, Leonardo Nicola</creatorcontrib><creatorcontrib>Rosenstein, Ruth E.</creatorcontrib><title>Diurnal Variations in Cyclic AMP and Melatonin Content of Golden Hamster Retina</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: The diurnal variations and photic regulation of cyclic AMP and melatonin content in golden hamster retina were studied. Both parameters showed significant diurnal variations with maximal values at night. Light exposure during the night inhibited retinal cyclic AMP and melatonin levels, whereas exposure to darkness during the day significantly increased cyclic AMP and melatonin content. Incubation with melatonin of retinas excised at different intervals indicated that the methoxyindole inhibited cyclic AMP accumulation in a time‐dependent manner. The inhibitory effect of melatonin at 2400 h and at noon showed a threshold concentration of 1 and 10 pM, respectively. At 0400 h melatonin did not affect cyclic AMP accumulation. The results indicate a diurnal variability of retinal cyclic AMP and melatonin content in hamsters, mainly influenced by a photic stimulus. Cyclic AMP could be a putative second messenger for melatonin action in golden hamster retina.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm</subject><subject>Cricetinae</subject><subject>Cyclic AMP</subject><subject>Cyclic AMP - metabolism</subject><subject>Darkness</subject><subject>Diurnal variations</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Golden hamster</subject><subject>Light</subject><subject>Male</subject><subject>Melatonin</subject><subject>Melatonin - metabolism</subject><subject>Melatonin - pharmacology</subject><subject>Mesocricetus</subject><subject>Radioimmunoassay</subject><subject>Retina</subject><subject>Retina - drug effects</subject><subject>Retina - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMtKxDAUhoMoOl4eQQgo7lqTNkkb3DiMd7wh6jYc0wQyZFJNOui8vS0zzt7VOfB_58KH0BElOSVMnE5zyiqaMcplTqVkuSgI7xue_2yg0TrbRCNCiiIrCSt20G5KU0KoYIJuo-2a8poyMUJPF24eA3j8DtFB59qQsAt4stDeaTx-eMYQGvxgPHRtGII2dCZ0uLX4uvWNCfgGZqkzEb-YzgXYR1sWfDIHq7qH3q4uXyc32f3T9e1kfJ9pRhjPGlKbDy1LzhotdFVZQcraksJKaaCqudVWaOA1CC2hFrxgXFRUN4Jaxi2V5R46We79jO3X3KROzVzSxnsIpp0nVQnGuCSsB8-WoI5tStFY9RndDOJCUaIGnWqqBmVqUKYGnepPp_rppw9XZ-YfM9OsZ1f--vx4lUPS4G2EoF1aY4zWZVFWPXa-xL6dN4v_fKDuHidDV_4CQdOQIA</recordid><startdate>199405</startdate><enddate>199405</enddate><creator>Faillace, María P.</creator><creator>Sarmiento, María I. Keller</creator><creator>Siri, Leonardo Nicola</creator><creator>Rosenstein, Ruth E.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199405</creationdate><title>Diurnal Variations in Cyclic AMP and Melatonin Content of Golden Hamster Retina</title><author>Faillace, María P. ; Sarmiento, María I. Keller ; Siri, Leonardo Nicola ; Rosenstein, Ruth E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4045-d08ebc9354dc6c77f6038f02f99ea785fcf6ca58a6c9a865245671cd61f45f193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Circadian Rhythm</topic><topic>Cricetinae</topic><topic>Cyclic AMP</topic><topic>Cyclic AMP - metabolism</topic><topic>Darkness</topic><topic>Diurnal variations</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Golden hamster</topic><topic>Light</topic><topic>Male</topic><topic>Melatonin</topic><topic>Melatonin - metabolism</topic><topic>Melatonin - pharmacology</topic><topic>Mesocricetus</topic><topic>Radioimmunoassay</topic><topic>Retina</topic><topic>Retina - drug effects</topic><topic>Retina - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faillace, María P.</creatorcontrib><creatorcontrib>Sarmiento, María I. Keller</creatorcontrib><creatorcontrib>Siri, Leonardo Nicola</creatorcontrib><creatorcontrib>Rosenstein, Ruth E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faillace, María P.</au><au>Sarmiento, María I. Keller</au><au>Siri, Leonardo Nicola</au><au>Rosenstein, Ruth E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diurnal Variations in Cyclic AMP and Melatonin Content of Golden Hamster Retina</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1994-05</date><risdate>1994</risdate><volume>62</volume><issue>5</issue><spage>1995</spage><epage>2000</epage><pages>1995-2000</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: The diurnal variations and photic regulation of cyclic AMP and melatonin content in golden hamster retina were studied. Both parameters showed significant diurnal variations with maximal values at night. Light exposure during the night inhibited retinal cyclic AMP and melatonin levels, whereas exposure to darkness during the day significantly increased cyclic AMP and melatonin content. Incubation with melatonin of retinas excised at different intervals indicated that the methoxyindole inhibited cyclic AMP accumulation in a time‐dependent manner. The inhibitory effect of melatonin at 2400 h and at noon showed a threshold concentration of 1 and 10 pM, respectively. At 0400 h melatonin did not affect cyclic AMP accumulation. The results indicate a diurnal variability of retinal cyclic AMP and melatonin content in hamsters, mainly influenced by a photic stimulus. Cyclic AMP could be a putative second messenger for melatonin action in golden hamster retina.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8158146</pmid><doi>10.1046/j.1471-4159.1994.62051995.x</doi><tpages>6</tpages></addata></record> |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Animals Biological and medical sciences Circadian Rhythm Cricetinae Cyclic AMP Cyclic AMP - metabolism Darkness Diurnal variations Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Golden hamster Light Male Melatonin Melatonin - metabolism Melatonin - pharmacology Mesocricetus Radioimmunoassay Retina Retina - drug effects Retina - metabolism Vertebrates: nervous system and sense organs |
| title | Diurnal Variations in Cyclic AMP and Melatonin Content of Golden Hamster Retina |
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