Isologous and heterologous platelet aggregation induced by tumor cells from three murine mammary gland adenocarcinomas with different metastatic abilities

The addition of neoplastic cells (NC) isolated from murine mammary gland adenocarcinomas having moderate and high metastatic ability on in vitro heparinized mice platelet rich plasma (PRP) induced platelet aggregation. One non-metastatic line did not induce aggregation. The aggregatory effect was no...

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Veröffentlicht in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1994, Vol.45 (7), p.449-451
Hauptverfasser: Pasqualini, Maria Eugenia, Eynard, Aldo R.
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container_issue 7
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container_title Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie
container_volume 45
creator Pasqualini, Maria Eugenia
Eynard, Aldo R.
description The addition of neoplastic cells (NC) isolated from murine mammary gland adenocarcinomas having moderate and high metastatic ability on in vitro heparinized mice platelet rich plasma (PRP) induced platelet aggregation. One non-metastatic line did not induce aggregation. The aggregatory effect was not correlated with the metastatic abilities. None of the three types of tumors did cause aggregation on whole blood or PRP of rats. These adenocarcinomas seem to be suitable models to study in vitro the interactions between platelets and tumor cells having metastatic and non-metastatic potentials.
doi_str_mv 10.1016/S0940-2993(11)80380-5
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identifier ISSN: 0940-2993
ispartof Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 1994, Vol.45 (7), p.449-451
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Adenocarcinoma - pathology
Adenocarcinoma - physiopathology
Animal tumors. Experimental tumors
Animals
Biological and medical sciences
Experimental genital and mammary tumors
Female
Mammary gland adenocarcinoma, murine
Mammary Neoplasms, Experimental - pathology
Mammary Neoplasms, Experimental - physiopathology
Medical sciences
Metastases
Mice
Mice, Inbred BALB C
Neoplasm Metastasis
Platelet aggregation
Platelet Aggregation - physiology
Rats
Rats, Wistar
Tumor Cells, Cultured
Tumors
title Isologous and heterologous platelet aggregation induced by tumor cells from three murine mammary gland adenocarcinomas with different metastatic abilities
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