Inhibition of Luminol-Enhanced Chemiluminescence by Reduced Pterins
Luminol-enhanced chemiluminescence, initially induced by exogenous H2O2 or enzymatic reactions which generate reactive oxygen species in situ, is inhibited by reduced pterins. Except dihydroneopterin which is as effective as tetrahydroneopterin, all tetrahydropterins are more effective than dihydrop...
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| Veröffentlicht in: | Archives of biochemistry and biophysics 1994-04, Vol.310 (1), p.60-63 |
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| container_title | Archives of biochemistry and biophysics |
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| creator | Shen, R.S. |
| description | Luminol-enhanced chemiluminescence, initially induced by exogenous H2O2 or enzymatic reactions which generate reactive oxygen species in situ, is inhibited by reduced pterins. Except dihydroneopterin which is as effective as tetrahydroneopterin, all tetrahydropterins are more effective than dihydropterins, which in turn is more effective than oxidized pterins in removing reactive oxygen species such as O∸2 and H2O2. The antioxidant efficacy of some reduced pterins is better than ascorbic acid and L-glutathione. Reduced pterins may act as physiological scavengers for reactive oxygen species, and play an important role in cellular defense against oxidative damage. |
| doi_str_mv | 10.1006/abbi.1994.1140 |
| format | Article |
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Except dihydroneopterin which is as effective as tetrahydroneopterin, all tetrahydropterins are more effective than dihydropterins, which in turn is more effective than oxidized pterins in removing reactive oxygen species such as O∸2 and H2O2. The antioxidant efficacy of some reduced pterins is better than ascorbic acid and L-glutathione. Reduced pterins may act as physiological scavengers for reactive oxygen species, and play an important role in cellular defense against oxidative damage.</description><identifier>ISSN: 0003-9861</identifier><identifier>EISSN: 1096-0384</identifier><identifier>DOI: 10.1006/abbi.1994.1140</identifier><identifier>PMID: 8161222</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>aminopterin ; analogs & derivatives ; antioxidant properties ; Antioxidants ; Antioxidants - pharmacology ; biopterin ; Biopterins ; Biopterins - analogs & derivatives ; Biopterins - pharmacology ; chemiluminescence ; derivatives ; Evaluation Studies as Topic ; Glucose Oxidase ; Glucose Oxidase - metabolism ; hydrogen peroxide ; inhibition ; Luminescent Measurements ; Luminol ; Luminol - pharmacology ; metabolism ; Models, Chemical ; Oxidation-Reduction ; pharmacology ; physicochemical properties ; pteridines ; Pterins ; Pterins - pharmacology ; Reactive Oxygen Species ; Reactive Oxygen Species - metabolism ; Xanthine Oxidase ; Xanthine Oxidase - metabolism</subject><ispartof>Archives of biochemistry and biophysics, 1994-04, Vol.310 (1), p.60-63</ispartof><rights>1994 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-6e798b90ffcd34655675faf40487a6ea6459ee6f9cc397d9b3dbe7f7324aeec53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0003986184711404$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8161222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, R.S.</creatorcontrib><title>Inhibition of Luminol-Enhanced Chemiluminescence by Reduced Pterins</title><title>Archives of biochemistry and biophysics</title><addtitle>Arch Biochem Biophys</addtitle><description>Luminol-enhanced chemiluminescence, initially induced by exogenous H2O2 or enzymatic reactions which generate reactive oxygen species in situ, is inhibited by reduced pterins. Except dihydroneopterin which is as effective as tetrahydroneopterin, all tetrahydropterins are more effective than dihydropterins, which in turn is more effective than oxidized pterins in removing reactive oxygen species such as O∸2 and H2O2. The antioxidant efficacy of some reduced pterins is better than ascorbic acid and L-glutathione. Reduced pterins may act as physiological scavengers for reactive oxygen species, and play an important role in cellular defense against oxidative damage.</description><subject>aminopterin</subject><subject>analogs & derivatives</subject><subject>antioxidant properties</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>biopterin</subject><subject>Biopterins</subject><subject>Biopterins - analogs & derivatives</subject><subject>Biopterins - pharmacology</subject><subject>chemiluminescence</subject><subject>derivatives</subject><subject>Evaluation Studies as Topic</subject><subject>Glucose Oxidase</subject><subject>Glucose Oxidase - metabolism</subject><subject>hydrogen peroxide</subject><subject>inhibition</subject><subject>Luminescent Measurements</subject><subject>Luminol</subject><subject>Luminol - pharmacology</subject><subject>metabolism</subject><subject>Models, Chemical</subject><subject>Oxidation-Reduction</subject><subject>pharmacology</subject><subject>physicochemical properties</subject><subject>pteridines</subject><subject>Pterins</subject><subject>Pterins - pharmacology</subject><subject>Reactive Oxygen Species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Xanthine Oxidase</subject><subject>Xanthine Oxidase - metabolism</subject><issn>0003-9861</issn><issn>1096-0384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtLJDEQh8OijKPudW9in7z1bKWTTjpHGXwMDLi4eg7pdGUn0g9NugX_-00zgzfxVFC_rx58hPyisKIA4repa7-iSvEVpRx-kCUFJXJgFT8iSwBguaoEPSGnMb4AJEYUC7KoqKBFUSzJetPvfO1HP_TZ4LLt1Pl-aPObfmd6i0223mHn27mL0WJqZfVH9ojNNId_Rgy-j-fk2Jk24s9DPSPPtzdP6_t8-3C3WV9vc8sUH3OBUlW1Audsw7goSyFLZxwHXkkj0AheKkThlE28bFTNmhqlk6zgBtGW7Ixc7fe-huFtwjjqzqen2tb0OExRS8E5lVx9C3KpoGQcErjagzYMMQZ0-jX4zoQPTUHPevWsV8969aw3DVwcNk91h80nfvCZ8st97sygzb_go37-WwBlQLkCqmgiqj2BydS7x6Cj9bPYxge0o24G_9Xx_1cjkhI</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>Shen, R.S.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>7X8</scope></search><sort><creationdate>19940401</creationdate><title>Inhibition of Luminol-Enhanced Chemiluminescence by Reduced Pterins</title><author>Shen, R.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-6e798b90ffcd34655675faf40487a6ea6459ee6f9cc397d9b3dbe7f7324aeec53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>aminopterin</topic><topic>analogs & derivatives</topic><topic>antioxidant properties</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>biopterin</topic><topic>Biopterins</topic><topic>Biopterins - analogs & derivatives</topic><topic>Biopterins - pharmacology</topic><topic>chemiluminescence</topic><topic>derivatives</topic><topic>Evaluation Studies as Topic</topic><topic>Glucose Oxidase</topic><topic>Glucose Oxidase - metabolism</topic><topic>hydrogen peroxide</topic><topic>inhibition</topic><topic>Luminescent Measurements</topic><topic>Luminol</topic><topic>Luminol - pharmacology</topic><topic>metabolism</topic><topic>Models, Chemical</topic><topic>Oxidation-Reduction</topic><topic>pharmacology</topic><topic>physicochemical properties</topic><topic>pteridines</topic><topic>Pterins</topic><topic>Pterins - pharmacology</topic><topic>Reactive Oxygen Species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Xanthine Oxidase</topic><topic>Xanthine Oxidase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, R.S.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, R.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Luminol-Enhanced Chemiluminescence by Reduced Pterins</atitle><jtitle>Archives of biochemistry and biophysics</jtitle><addtitle>Arch Biochem Biophys</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>310</volume><issue>1</issue><spage>60</spage><epage>63</epage><pages>60-63</pages><issn>0003-9861</issn><eissn>1096-0384</eissn><abstract>Luminol-enhanced chemiluminescence, initially induced by exogenous H2O2 or enzymatic reactions which generate reactive oxygen species in situ, is inhibited by reduced pterins. Except dihydroneopterin which is as effective as tetrahydroneopterin, all tetrahydropterins are more effective than dihydropterins, which in turn is more effective than oxidized pterins in removing reactive oxygen species such as O∸2 and H2O2. The antioxidant efficacy of some reduced pterins is better than ascorbic acid and L-glutathione. Reduced pterins may act as physiological scavengers for reactive oxygen species, and play an important role in cellular defense against oxidative damage.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8161222</pmid><doi>10.1006/abbi.1994.1140</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-9861 |
| ispartof | Archives of biochemistry and biophysics, 1994-04, Vol.310 (1), p.60-63 |
| issn | 0003-9861 1096-0384 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76441749 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | aminopterin analogs & derivatives antioxidant properties Antioxidants Antioxidants - pharmacology biopterin Biopterins Biopterins - analogs & derivatives Biopterins - pharmacology chemiluminescence derivatives Evaluation Studies as Topic Glucose Oxidase Glucose Oxidase - metabolism hydrogen peroxide inhibition Luminescent Measurements Luminol Luminol - pharmacology metabolism Models, Chemical Oxidation-Reduction pharmacology physicochemical properties pteridines Pterins Pterins - pharmacology Reactive Oxygen Species Reactive Oxygen Species - metabolism Xanthine Oxidase Xanthine Oxidase - metabolism |
| title | Inhibition of Luminol-Enhanced Chemiluminescence by Reduced Pterins |
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