Effect of chronic treatment with the antidepressant tianeptine on the hypothalamo-pituitary-adrenal axis

The effects of acute and chronic administration of tianeptine, a novel antidepressant agent, on the hypothalamo-pituitary-adrenal axis were studied in the adult male rat. A single injection of tianeptine did not alter the activity of the hypothalamo-pituitary-adrenal axi axis. In contrast, chronic a...

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Veröffentlicht in:	European journal of pharmacology 1994-01, Vol.251 (2), p.245-251
Hauptverfasser:	Delbende, Catherine, Bunel, Denis Tranchand, Tarozzo, Glauco, Grino, Michel, Oliver, Charles, Mocaër, Elisabeth, Vaudry, Hubert
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT (5-hydroxytryptamine, serotonin) ACTH (adrenocorticotropin) Animals Antidepressant Antidepressive Agents, Tricyclic - pharmacology Biological and medical sciences Corticosterone CRF (corticotropin-releasing factor) Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiology Hypothalamo-pituitary-adrenal axis Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiology Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Stress Stress, Physiological - drug therapy Stress, Physiological - physiopathology Thiazepines - pharmacology Tianeptine Time Factors
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