Chronic nicotine intake decelerates aging of nigrostriatal dopaminergic neurons
We have evaluated the effect of chronic nicotine intake on the age-associated loss of nigrostriatal dopaminergic neurons. The striatal density of dopamine (D1 and D 2) receptors and DA-uptake sites decreased with age. Concomitant with these changes was a pronounced loss of many behavioral functions...
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| Veröffentlicht in: | Life sciences (1973) 1994, Vol.54 (16), p.1169-1184 |
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| container_end_page | 1184 |
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| container_issue | 16 |
| container_start_page | 1169 |
| container_title | Life sciences (1973) |
| container_volume | 54 |
| creator | Prasad, Chandan Hiromasa Ikegami Ikuya Shimizu Onaivi, Emmanuel S. |
| description | We have evaluated the effect of chronic nicotine intake on the age-associated loss of nigrostriatal dopaminergic neurons. The striatal density of dopamine (D1 and D
2) receptors and DA-uptake sites decreased with age. Concomitant with these changes was a pronounced loss of many behavioral functions associated, at least in part, with dopaminergic neurotransmission. Chronic oral intake of nicotine resulted in partial restoration of the loss of receptors as well as behavioral performances. The results suggest that low doses of nicotine could have beneficial effects during aging. |
| doi_str_mv | 10.1016/0024-3205(94)00839-6 |
| format | Article |
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2) receptors and DA-uptake sites decreased with age. Concomitant with these changes was a pronounced loss of many behavioral functions associated, at least in part, with dopaminergic neurotransmission. Chronic oral intake of nicotine resulted in partial restoration of the loss of receptors as well as behavioral performances. The results suggest that low doses of nicotine could have beneficial effects during aging.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(94)00839-6</identifier><identifier>PMID: 8152341</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>aging ; Aging - metabolism ; Animals ; Apomorphine - pharmacology ; Benzazepines - metabolism ; Binding Sites ; Biological and medical sciences ; Body Weight - drug effects ; Cellular Senescence - drug effects ; Cholinergic system ; Corpus Striatum - cytology ; Corpus Striatum - drug effects ; Corpus Striatum - metabolism ; Domperidone - metabolism ; Dopamine - metabolism ; Male ; Mazindol - metabolism ; Medical sciences ; Neurons - drug effects ; Neurons - metabolism ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; nicotine ; Nicotine - administration & dosage ; Nicotine - pharmacology ; nigrostriatal dopaminergic neurons ; Parkinson's disease ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred F344 ; Receptors, Dopamine D1 - metabolism ; Receptors, Dopamine D2 - metabolism ; Substantia Nigra - cytology ; Substantia Nigra - drug effects ; Substantia Nigra - metabolism</subject><ispartof>Life sciences (1973), 1994, Vol.54 (16), p.1169-1184</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-27d65b49df328215d98ab2daf17d15bfcaa4339b8fc6465f3fc7c613f6939f263</citedby><cites>FETCH-LOGICAL-c417t-27d65b49df328215d98ab2daf17d15bfcaa4339b8fc6465f3fc7c613f6939f263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(94)00839-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4064150$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8152341$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prasad, Chandan</creatorcontrib><creatorcontrib>Hiromasa Ikegami</creatorcontrib><creatorcontrib>Ikuya Shimizu</creatorcontrib><creatorcontrib>Onaivi, Emmanuel S.</creatorcontrib><title>Chronic nicotine intake decelerates aging of nigrostriatal dopaminergic neurons</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>We have evaluated the effect of chronic nicotine intake on the age-associated loss of nigrostriatal dopaminergic neurons. The striatal density of dopamine (D1 and D
2) receptors and DA-uptake sites decreased with age. Concomitant with these changes was a pronounced loss of many behavioral functions associated, at least in part, with dopaminergic neurotransmission. Chronic oral intake of nicotine resulted in partial restoration of the loss of receptors as well as behavioral performances. The results suggest that low doses of nicotine could have beneficial effects during aging.</description><subject>aging</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Apomorphine - pharmacology</subject><subject>Benzazepines - metabolism</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Cellular Senescence - drug effects</subject><subject>Cholinergic system</subject><subject>Corpus Striatum - cytology</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - metabolism</subject><subject>Domperidone - metabolism</subject><subject>Dopamine - metabolism</subject><subject>Male</subject><subject>Mazindol - metabolism</subject><subject>Medical sciences</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>nicotine</subject><subject>Nicotine - administration & dosage</subject><subject>Nicotine - pharmacology</subject><subject>nigrostriatal dopaminergic neurons</subject><subject>Parkinson's disease</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Receptors, Dopamine D1 - metabolism</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Substantia Nigra - cytology</subject><subject>Substantia Nigra - drug effects</subject><subject>Substantia Nigra - metabolism</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMoOl7eQKELEV1Uk-bSZCPI4A0EN7oOaXIyRjvtmHQE397UGWapi5DF-f6fcz6Ejgm-JJiIK4wrVtIK83PFLjCWVJViC02IrFWJBSXbaLJB9tB-Su8YY85ruot2JeEVZWSCnqdvse-CLfLrh9BBEbrBfEDhwEIL0QyQCjML3azofYZmsU9DDGYwbeH6hZnnSJyNeVjmonSIdrxpExyt_wP0enf7Mn0on57vH6c3T6VlpB7KqnaCN0w5TytZEe6UNE3ljCe1I7zx1hhGqWqkt4IJ7qm3tRWEeqGo8pWgB-hs1buI_ecS0qDnIeWNW9NBv0y6FoyKOh_5H0iEFEJKnkG2Am0-MUXwehHD3MRvTbAehevRph5tasX0r3A9LnKy7l82c3Cb0Npwnp-u5yZZ0_poOhvSBmNYMMJxxq5XGGRpXwGiTjZAZ8GFCHbQrg9_7_EDdficeQ</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Prasad, Chandan</creator><creator>Hiromasa Ikegami</creator><creator>Ikuya Shimizu</creator><creator>Onaivi, Emmanuel S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Chronic nicotine intake decelerates aging of nigrostriatal dopaminergic neurons</title><author>Prasad, Chandan ; Hiromasa Ikegami ; Ikuya Shimizu ; Onaivi, Emmanuel S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-27d65b49df328215d98ab2daf17d15bfcaa4339b8fc6465f3fc7c613f6939f263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>aging</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Apomorphine - pharmacology</topic><topic>Benzazepines - metabolism</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Cellular Senescence - drug effects</topic><topic>Cholinergic system</topic><topic>Corpus Striatum - cytology</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - metabolism</topic><topic>Domperidone - metabolism</topic><topic>Dopamine - metabolism</topic><topic>Male</topic><topic>Mazindol - metabolism</topic><topic>Medical sciences</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>nicotine</topic><topic>Nicotine - administration & dosage</topic><topic>Nicotine - pharmacology</topic><topic>nigrostriatal dopaminergic neurons</topic><topic>Parkinson's disease</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Receptors, Dopamine D1 - metabolism</topic><topic>Receptors, Dopamine D2 - metabolism</topic><topic>Substantia Nigra - cytology</topic><topic>Substantia Nigra - drug effects</topic><topic>Substantia Nigra - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prasad, Chandan</creatorcontrib><creatorcontrib>Hiromasa Ikegami</creatorcontrib><creatorcontrib>Ikuya Shimizu</creatorcontrib><creatorcontrib>Onaivi, Emmanuel S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prasad, Chandan</au><au>Hiromasa Ikegami</au><au>Ikuya Shimizu</au><au>Onaivi, Emmanuel S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic nicotine intake decelerates aging of nigrostriatal dopaminergic neurons</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1994</date><risdate>1994</risdate><volume>54</volume><issue>16</issue><spage>1169</spage><epage>1184</epage><pages>1169-1184</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>We have evaluated the effect of chronic nicotine intake on the age-associated loss of nigrostriatal dopaminergic neurons. The striatal density of dopamine (D1 and D
2) receptors and DA-uptake sites decreased with age. Concomitant with these changes was a pronounced loss of many behavioral functions associated, at least in part, with dopaminergic neurotransmission. Chronic oral intake of nicotine resulted in partial restoration of the loss of receptors as well as behavioral performances. The results suggest that low doses of nicotine could have beneficial effects during aging.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>8152341</pmid><doi>10.1016/0024-3205(94)00839-6</doi><tpages>16</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | aging Aging - metabolism Animals Apomorphine - pharmacology Benzazepines - metabolism Binding Sites Biological and medical sciences Body Weight - drug effects Cellular Senescence - drug effects Cholinergic system Corpus Striatum - cytology Corpus Striatum - drug effects Corpus Striatum - metabolism Domperidone - metabolism Dopamine - metabolism Male Mazindol - metabolism Medical sciences Neurons - drug effects Neurons - metabolism Neuropharmacology Neurotransmitters. Neurotransmission. Receptors nicotine Nicotine - administration & dosage Nicotine - pharmacology nigrostriatal dopaminergic neurons Parkinson's disease Pharmacology. Drug treatments Rats Rats, Inbred F344 Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism Substantia Nigra - cytology Substantia Nigra - drug effects Substantia Nigra - metabolism |
| title | Chronic nicotine intake decelerates aging of nigrostriatal dopaminergic neurons |
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