Dopamine receptor density, sensitivity and mRNA levels are altered following self-administration of cocaine in the rat
The effects of cocaine administration and withdrawal on D 1 and D 2 dopamine receptor number, affinity, and mRNA levels were examined in rats trained to self-administer cocaine for four weeks on a continuous reinforcement schedule. Two hours after the last infusion of cocaine there was a decrease in...
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| Veröffentlicht in: | Brain research 1994-01, Vol.634 (1), p.31-40 |
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| creator | Laurier, Lisanne G. Corrigall, William A. George, Susan R. |
| description | The effects of cocaine administration and withdrawal on D
1 and D
2 dopamine receptor number, affinity, and mRNA levels were examined in rats trained to self-administer cocaine for four weeks on a continuous reinforcement schedule. Two hours after the last infusion of cocaine there was a decrease in the number and agonist sensitivity of dopamine D
1 receptors in the anterior forebrain as well as in the limbic region. In contrast, there were no discernible changes in dopamine D
2 receptors in any of the brain regions examined. Examination of dopamine receptor gene expression using Northern blot analysis revealed that there was an increase in D
1 receptor mRNA levels in the forebrain, whereas D
1 and D
2 receptor mRNA levels both were increased in the limbic region. One week following the last infusion of cocaine, D
1 and D
2 receptor mRNA levels had returned to baseline. In the limbic region, D
1 receptor numbers also had normalized by this time, whereas in the forebrain, changes in D
1 receptors persisted. These data indicate that repeated exposure to cocaine induces regional changes in D
1 receptor sensitivity and gene expression, suggesting that the D
1 dopamine system plays an important role in mediating the reinforcing effects of cocaine. |
| doi_str_mv | 10.1016/0006-8993(94)90255-0 |
| format | Article |
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1 and D
2 dopamine receptor number, affinity, and mRNA levels were examined in rats trained to self-administer cocaine for four weeks on a continuous reinforcement schedule. Two hours after the last infusion of cocaine there was a decrease in the number and agonist sensitivity of dopamine D
1 receptors in the anterior forebrain as well as in the limbic region. In contrast, there were no discernible changes in dopamine D
2 receptors in any of the brain regions examined. Examination of dopamine receptor gene expression using Northern blot analysis revealed that there was an increase in D
1 receptor mRNA levels in the forebrain, whereas D
1 and D
2 receptor mRNA levels both were increased in the limbic region. One week following the last infusion of cocaine, D
1 and D
2 receptor mRNA levels had returned to baseline. In the limbic region, D
1 receptor numbers also had normalized by this time, whereas in the forebrain, changes in D
1 receptors persisted. These data indicate that repeated exposure to cocaine induces regional changes in D
1 receptor sensitivity and gene expression, suggesting that the D
1 dopamine system plays an important role in mediating the reinforcing effects of cocaine.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(94)90255-0</identifier><identifier>PMID: 8156390</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Brain - drug effects ; Cocaine - administration & dosage ; Cocaine dopamine receptors desensitization mRNA ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Receptors, Dopamine D1 - drug effects ; Receptors, Dopamine D1 - genetics ; Receptors, Dopamine D2 - drug effects ; Receptors, Dopamine D2 - genetics ; RNA, Messenger - drug effects ; RNA, Messenger - metabolism ; Self Administration</subject><ispartof>Brain research, 1994-01, Vol.634 (1), p.31-40</ispartof><rights>1994 Elsevier Science B.V. All rights reserved</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-fcdce4d8249ff40f41cf97331f550ef2c021f0e4bc5a256a538d223b04b6ff33</citedby><cites>FETCH-LOGICAL-c332t-fcdce4d8249ff40f41cf97331f550ef2c021f0e4bc5a256a538d223b04b6ff33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(94)90255-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3873775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8156390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laurier, Lisanne G.</creatorcontrib><creatorcontrib>Corrigall, William A.</creatorcontrib><creatorcontrib>George, Susan R.</creatorcontrib><title>Dopamine receptor density, sensitivity and mRNA levels are altered following self-administration of cocaine in the rat</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The effects of cocaine administration and withdrawal on D
1 and D
2 dopamine receptor number, affinity, and mRNA levels were examined in rats trained to self-administer cocaine for four weeks on a continuous reinforcement schedule. Two hours after the last infusion of cocaine there was a decrease in the number and agonist sensitivity of dopamine D
1 receptors in the anterior forebrain as well as in the limbic region. In contrast, there were no discernible changes in dopamine D
2 receptors in any of the brain regions examined. Examination of dopamine receptor gene expression using Northern blot analysis revealed that there was an increase in D
1 receptor mRNA levels in the forebrain, whereas D
1 and D
2 receptor mRNA levels both were increased in the limbic region. One week following the last infusion of cocaine, D
1 and D
2 receptor mRNA levels had returned to baseline. In the limbic region, D
1 receptor numbers also had normalized by this time, whereas in the forebrain, changes in D
1 receptors persisted. These data indicate that repeated exposure to cocaine induces regional changes in D
1 receptor sensitivity and gene expression, suggesting that the D
1 dopamine system plays an important role in mediating the reinforcing effects of cocaine.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Cocaine - administration & dosage</subject><subject>Cocaine dopamine receptors desensitization mRNA</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Receptors, Dopamine D1 - drug effects</subject><subject>Receptors, Dopamine D1 - genetics</subject><subject>Receptors, Dopamine D2 - drug effects</subject><subject>Receptors, Dopamine D2 - genetics</subject><subject>RNA, Messenger - drug effects</subject><subject>RNA, Messenger - metabolism</subject><subject>Self Administration</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEUhoModVv9Bwq5EKngaL4mM3MjlPrRQlGQ3odscqKRTLIm2S399810l73Uq5zDed73hPMi9IqSD5RQ-ZEQIrtxmvj5JN5NhPV9R56gFR0H1kkmyFO0OiLP0Wkpf1rL-URO0MlIe9mqFdp9Ths9-wg4g4FNTRlbiMXX-_e4PBZ-1xqso8Xzz-8XOMAOQsE6A9ahQgaLXQoh3fn4qymC67Rtfr7UrKtPESeHTTJ6WeEjrr_bJl1foGdOhwIvD-8Zuv365fbyqrv58e368uKmM5yz2jljDQg7MjE5J4gT1Lhp4Jy6vifgmCGMOgJibXrNeql7PlrG-JqItXSO8zP0dm-7yenvFkpVsy8GQtAR0raoQQouJaP_BamUgg3D4ij2oMmplAxObbKfdb5XlKglFrXcXC03V5NQj7Eo0mSvD_7b9Qz2KDrk0OZvDnNdjA4u62h8OWJ8HPgw9A37tMdaBLDzkFUxHqIB61t8Vdnk__2PB2nJqmQ</recordid><startdate>19940114</startdate><enddate>19940114</enddate><creator>Laurier, Lisanne G.</creator><creator>Corrigall, William A.</creator><creator>George, Susan R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940114</creationdate><title>Dopamine receptor density, sensitivity and mRNA levels are altered following self-administration of cocaine in the rat</title><author>Laurier, Lisanne G. ; Corrigall, William A. ; George, Susan R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-fcdce4d8249ff40f41cf97331f550ef2c021f0e4bc5a256a538d223b04b6ff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Cocaine - administration & dosage</topic><topic>Cocaine dopamine receptors desensitization mRNA</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Receptors, Dopamine D1 - drug effects</topic><topic>Receptors, Dopamine D1 - genetics</topic><topic>Receptors, Dopamine D2 - drug effects</topic><topic>Receptors, Dopamine D2 - genetics</topic><topic>RNA, Messenger - drug effects</topic><topic>RNA, Messenger - metabolism</topic><topic>Self Administration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laurier, Lisanne G.</creatorcontrib><creatorcontrib>Corrigall, William A.</creatorcontrib><creatorcontrib>George, Susan R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laurier, Lisanne G.</au><au>Corrigall, William A.</au><au>George, Susan R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopamine receptor density, sensitivity and mRNA levels are altered following self-administration of cocaine in the rat</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1994-01-14</date><risdate>1994</risdate><volume>634</volume><issue>1</issue><spage>31</spage><epage>40</epage><pages>31-40</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The effects of cocaine administration and withdrawal on D
1 and D
2 dopamine receptor number, affinity, and mRNA levels were examined in rats trained to self-administer cocaine for four weeks on a continuous reinforcement schedule. Two hours after the last infusion of cocaine there was a decrease in the number and agonist sensitivity of dopamine D
1 receptors in the anterior forebrain as well as in the limbic region. In contrast, there were no discernible changes in dopamine D
2 receptors in any of the brain regions examined. Examination of dopamine receptor gene expression using Northern blot analysis revealed that there was an increase in D
1 receptor mRNA levels in the forebrain, whereas D
1 and D
2 receptor mRNA levels both were increased in the limbic region. One week following the last infusion of cocaine, D
1 and D
2 receptor mRNA levels had returned to baseline. In the limbic region, D
1 receptor numbers also had normalized by this time, whereas in the forebrain, changes in D
1 receptors persisted. These data indicate that repeated exposure to cocaine induces regional changes in D
1 receptor sensitivity and gene expression, suggesting that the D
1 dopamine system plays an important role in mediating the reinforcing effects of cocaine.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8156390</pmid><doi>10.1016/0006-8993(94)90255-0</doi><tpages>10</tpages></addata></record> |
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| ispartof | Brain research, 1994-01, Vol.634 (1), p.31-40 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Brain - drug effects Cocaine - administration & dosage Cocaine dopamine receptors desensitization mRNA Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Receptors, Dopamine D1 - drug effects Receptors, Dopamine D1 - genetics Receptors, Dopamine D2 - drug effects Receptors, Dopamine D2 - genetics RNA, Messenger - drug effects RNA, Messenger - metabolism Self Administration |
| title | Dopamine receptor density, sensitivity and mRNA levels are altered following self-administration of cocaine in the rat |
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