Genetic structures associated with spread of the type Ia trimethoprim-resistant dihydrofolate reductase gene amongst Escherichia coli strains isolated in the Nottingham area of the United Kingdom

DNA probes for specific integrase genes were used to study 122 R plasmids encoding the predominant trimethoprim-insusceptible type Ia dihydrofolate reductase (DHFR) found in clinical isolates of Escherichia coli. The predominance of the type Ia DHFR was thought to result from the location of its gen...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1994-01, Vol.33 (1), p.25-32
Hauptverfasser:	Towner, K J, Brennan, A, Zhang, Y, Holtham, C A, Brough, J L, Carter, G I
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriuria - microbiology DNA Probes Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli Infections - microbiology Genes, Bacterial Humans In Situ Hybridization R Factors - genetics Tetrahydrofolate Dehydrogenase - genetics Trimethoprim Resistance - genetics United Kingdom
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