Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study
Objective The objective of the study was to examine whether the risk of miscarriage is associated with caffeine consumption during pregnancy after controlling for pregnancy-related symptoms. Study Design This was a population-based prospective cohort study. Results An increasing dose of daily caffei...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2008-03, Vol.198 (3), p.279.e1-279.e8 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Weng, Xiaoping, PhD Odouli, Roxana, MSPH Li, De-Kun, MD, PhD |
| description | Objective The objective of the study was to examine whether the risk of miscarriage is associated with caffeine consumption during pregnancy after controlling for pregnancy-related symptoms. Study Design This was a population-based prospective cohort study. Results An increasing dose of daily caffeine intake during pregnancy was associated with an increased risk of miscarriage, compared with no caffeine intake, with an adjusted hazard ratio (aHR) of 1.42 (95% confidence interval 0.93 to 2.15) for caffeine intake of less than 200 mg/day, and aHR of 2.23 (1.34 to 3.69) for intake of 200 or more mg/day, respectively. Nausea or vomiting during pregnancy did not materially affect this observed association, nor did the change in intake pattern of caffeine during pregnancy. In addition, the magnitude of the association appeared to be stronger among women without a history of miscarriage (aHR 2.33, 1.48 to 3.67) than that among women with such a history (aHR 0.81, 0.34 to 1.94). Conclusion Our results demonstrated that high doses of caffeine intake during pregnancy increase the risk of miscarriage, independent of pregnancy-related symptoms. |
| doi_str_mv | 10.1016/j.ajog.2007.10.803 |
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Study Design This was a population-based prospective cohort study. Results An increasing dose of daily caffeine intake during pregnancy was associated with an increased risk of miscarriage, compared with no caffeine intake, with an adjusted hazard ratio (aHR) of 1.42 (95% confidence interval 0.93 to 2.15) for caffeine intake of less than 200 mg/day, and aHR of 2.23 (1.34 to 3.69) for intake of 200 or more mg/day, respectively. Nausea or vomiting during pregnancy did not materially affect this observed association, nor did the change in intake pattern of caffeine during pregnancy. In addition, the magnitude of the association appeared to be stronger among women without a history of miscarriage (aHR 2.33, 1.48 to 3.67) than that among women with such a history (aHR 0.81, 0.34 to 1.94). Conclusion Our results demonstrated that high doses of caffeine intake during pregnancy increase the risk of miscarriage, independent of pregnancy-related symptoms.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2007.10.803</identifier><identifier>PMID: 18221932</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>abortion ; Abortion, Spontaneous - chemically induced ; Abortion, Spontaneous - epidemiology ; Adult ; Beverages ; Biological and medical sciences ; caffeine ; Caffeine - adverse effects ; Diseases of mother, fetus and pregnancy ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; miscarriage ; Obstetrics and Gynecology ; Pregnancy ; Pregnancy. Fetus. Placenta ; Prospective Studies ; Risk Factors ; spontaneous</subject><ispartof>American journal of obstetrics and gynecology, 2008-03, Vol.198 (3), p.279.e1-279.e8</ispartof><rights>Mosby, Inc.</rights><rights>2008 Mosby, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-7304586da4a5da2e5eac13037128af4ba819ba694c7eb689fb023494bb2ccb993</citedby><cites>FETCH-LOGICAL-c537t-7304586da4a5da2e5eac13037128af4ba819ba694c7eb689fb023494bb2ccb993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000293780702025X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20169791$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18221932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weng, Xiaoping, PhD</creatorcontrib><creatorcontrib>Odouli, Roxana, MSPH</creatorcontrib><creatorcontrib>Li, De-Kun, MD, PhD</creatorcontrib><title>Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective The objective of the study was to examine whether the risk of miscarriage is associated with caffeine consumption during pregnancy after controlling for pregnancy-related symptoms. Study Design This was a population-based prospective cohort study. Results An increasing dose of daily caffeine intake during pregnancy was associated with an increased risk of miscarriage, compared with no caffeine intake, with an adjusted hazard ratio (aHR) of 1.42 (95% confidence interval 0.93 to 2.15) for caffeine intake of less than 200 mg/day, and aHR of 2.23 (1.34 to 3.69) for intake of 200 or more mg/day, respectively. Nausea or vomiting during pregnancy did not materially affect this observed association, nor did the change in intake pattern of caffeine during pregnancy. In addition, the magnitude of the association appeared to be stronger among women without a history of miscarriage (aHR 2.33, 1.48 to 3.67) than that among women with such a history (aHR 0.81, 0.34 to 1.94). Conclusion Our results demonstrated that high doses of caffeine intake during pregnancy increase the risk of miscarriage, independent of pregnancy-related symptoms.</description><subject>abortion</subject><subject>Abortion, Spontaneous - chemically induced</subject><subject>Abortion, Spontaneous - epidemiology</subject><subject>Adult</subject><subject>Beverages</subject><subject>Biological and medical sciences</subject><subject>caffeine</subject><subject>Caffeine - adverse effects</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>miscarriage</subject><subject>Obstetrics and Gynecology</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>spontaneous</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2LFDEQhoMo7rj6BzxILuKpx3x0dzoigix-wYoHFbyF6nT1bHp7ktmke2H-vQkzKHjwFFI8VXl5KoQ852zLGW9fT1uYwm4rGFO5sO2YfEA2nGlVtV3bPSQbxpiotFTdBXmS0lSuQovH5IJ3QnAtxYaMX2HB6GGmFsYRnUdqg0_r_rC44OmwRud39BBx58HbIwU_0OUGaXTploaR7l2yEKODHb6hkMGQDmgXd1_m3IS40LSsw_EpeTTCnPDZ-bwkPz9--HH1ubr-9unL1fvryjZSLZWSrG66doAamgEENgiWSyYVFx2MdQ8d1z20urYK-7bTY8-ErHXd98LaXmt5SV6d5uYgdyumxZSAOM_gMazJqLaWTStFIcWJtDlyijiaQ3R7iEfDmSl6zWSKXlP0llrWm5tenMev_R6Hvy1nnxl4eQYge5nHmKW59IcTea5Wmmfu7YnDLOPeYTTJOvQWBxezPjME9_8c7_5pt7PzLr94i0dMU1jLSpPhJgnDzPey-fIPmGKCieaX_A2rBK7j</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Weng, Xiaoping, PhD</creator><creator>Odouli, Roxana, MSPH</creator><creator>Li, De-Kun, MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope></search><sort><creationdate>20080301</creationdate><title>Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study</title><author>Weng, Xiaoping, PhD ; Odouli, Roxana, MSPH ; Li, De-Kun, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-7304586da4a5da2e5eac13037128af4ba819ba694c7eb689fb023494bb2ccb993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>abortion</topic><topic>Abortion, Spontaneous - chemically induced</topic><topic>Abortion, Spontaneous - epidemiology</topic><topic>Adult</topic><topic>Beverages</topic><topic>Biological and medical sciences</topic><topic>caffeine</topic><topic>Caffeine - adverse effects</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>miscarriage</topic><topic>Obstetrics and Gynecology</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>spontaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weng, Xiaoping, PhD</creatorcontrib><creatorcontrib>Odouli, Roxana, MSPH</creatorcontrib><creatorcontrib>Li, De-Kun, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weng, Xiaoping, PhD</au><au>Odouli, Roxana, MSPH</au><au>Li, De-Kun, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>198</volume><issue>3</issue><spage>279.e1</spage><epage>279.e8</epage><pages>279.e1-279.e8</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective The objective of the study was to examine whether the risk of miscarriage is associated with caffeine consumption during pregnancy after controlling for pregnancy-related symptoms. Study Design This was a population-based prospective cohort study. Results An increasing dose of daily caffeine intake during pregnancy was associated with an increased risk of miscarriage, compared with no caffeine intake, with an adjusted hazard ratio (aHR) of 1.42 (95% confidence interval 0.93 to 2.15) for caffeine intake of less than 200 mg/day, and aHR of 2.23 (1.34 to 3.69) for intake of 200 or more mg/day, respectively. Nausea or vomiting during pregnancy did not materially affect this observed association, nor did the change in intake pattern of caffeine during pregnancy. In addition, the magnitude of the association appeared to be stronger among women without a history of miscarriage (aHR 2.33, 1.48 to 3.67) than that among women with such a history (aHR 0.81, 0.34 to 1.94). Conclusion Our results demonstrated that high doses of caffeine intake during pregnancy increase the risk of miscarriage, independent of pregnancy-related symptoms.</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>18221932</pmid><doi>10.1016/j.ajog.2007.10.803</doi><tpages>3</tpages></addata></record> |
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| subjects | abortion Abortion, Spontaneous - chemically induced Abortion, Spontaneous - epidemiology Adult Beverages Biological and medical sciences caffeine Caffeine - adverse effects Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans Medical sciences miscarriage Obstetrics and Gynecology Pregnancy Pregnancy. Fetus. Placenta Prospective Studies Risk Factors spontaneous |
| title | Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study |
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