THE USE OF FORSKOLIN TO INVESTIGATE THE SITE OF CARDIAC β-ADRENORECEPTOR SUPERSENSITIVITY

The positive inotropic responses of left atria and papillary muscles and the positive chronotropic responses of right atria of guinea-pigs to isoprenaline and forskolin were examined. An increase in sensitivity of the three preparations to isoprenaline was observed by lowering the bath temperature f...

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Veröffentlicht in:	Journal of autonomic pharmacology 1985-09, Vol.5 (3), p.231-240
Hauptverfasser:	HAWTHORN, M. H., CHESS-WILLIAMS, R. G., GRASSBY, P. F., BROADLEY, K. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenylate cyclase Animals beta -adrenergic cardiac muscle chronotropism Colforsin forskolin Guinea Pigs Heart - drug effects In Vitro Techniques Isoproterenol - pharmacology Male Myocardial Contraction - drug effects Papillary Muscles - drug effects Propranolol - pharmacology Receptors, Adrenergic, beta - drug effects Reserpine - pharmacology Temperature
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