Contractile Arrest Increases Sarcoplasmic Reticulum Calcium Uptake and SERCA2 Gene Expression in Cultured Neonatal Rat Heart Cells

We developed protocols with intact cultured neonatal rat myocytes to directly evaluate the function of the sarcoplasmic reticulum (SR) Ca-ATPase (or SERCA2), Na-Ca exchange (Na-CaX), and slow Ca transport systems (mitochondria and sarcolemmal Ca-ATPase}. Spontaneously beating control cells were comp...

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Veröffentlicht in:	Circulation research 1994-05, Vol.74 (5), p.991-997
Hauptverfasser:	Bassani, José W.M, Qi, Ming, Samarel, Allen M, Bers, Donald M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Caffeine - pharmacology Calcium - metabolism Calcium-Transporting ATPases - genetics Calcium-Transporting ATPases - metabolism Carrier Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation Heart Major Histocompatibility Complex Myocardial Contraction - drug effects Myocardium - metabolism Rats RNA, Messenger - metabolism Sarcoplasmic Reticulum - metabolism Sodium-Calcium Exchanger Verapamil - pharmacology Vertebrates: cardiovascular system
Online-Zugang:	Volltext
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