Binding of unglycosylated and glycosylated human recombinant interferon-γ to cellular receptors

Recombinant human interferons (IFNs), either unglycosylated produced in E. coli (rIFN-gamma) or glycosylated produced in CHO cells (g-rIFN-gamma), were labeled with 125I to similar specific activities to study their interaction with cell-surface receptors. When analyzed by gel electrophoresis, rIFN-...

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Veröffentlicht in:	Journal of interferon research 1985, Vol.5 (3), p.471-476
Hauptverfasser:	LITTMAN, S. J, DEVOS, R, BAGLIONI, C
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - metabolism Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Cell Line CHO cells Escherichia coli - genetics Fundamental and applied biological sciences. Psychology Fundamental immunology gamma -interferon HeLa Cells - enzymology Humans Immunobiology Interferon-gamma - genetics Interferon-gamma - isolation & purification Interferon-gamma - metabolism Kinetics Miscellaneous Molecular Weight Receptors, Immunologic - metabolism Receptors, Interferon Recombinant Proteins - metabolism Regulatory factors and their cellular receptors Structure-Activity Relationship
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