Stimulation by Ionophores of Tyrosinase Activity of Mouse Melanoma Cells in Culture

The hypothesis that the melanosome is an acidic vesicle in which the tyrosinase action is suppressed under the ordinary culture conditions was examined with a variety of ionophores added in cultures of mouse melanoma cell line B16-C2M. In the presence of monensin or nigericin, which exchange H+ for...

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Veröffentlicht in:	Journal of investigative dermatology 1985-11, Vol.85 (5), p.423-425
Hauptverfasser:	Saeki, Hisaaki, Oikawa, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Biological and medical sciences Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone - pharmacology Catechol Oxidase - metabolism Cell-Free System Cells, Cultured Dose-Response Relationship, Drug Enzyme Activation - drug effects Experimental skin tumors Hydrogen-Ion Concentration Ionophores - pharmacology Medical sciences Melanoma - enzymology Melanoma - pathology Mice Monensin - pharmacology Monophenol Monooxygenase - metabolism Tumors
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