Photodynamic therapy for atherosclerotic stenoses in Yucatan miniswine
To determine the feasibility of treating atherosclerotic stenoses with photodynamic therapy (PDT). A prospective study with a 4-week follow-up. Twelve Yucatan miniswine, weighing between 25 and 35 kg. Aortoiliac atherosclerosis was created by a combination of balloon endothelial injury and dietary s...
Gespeichert in:
| Veröffentlicht in: | Canadian Journal of Surgery 1994-04, Vol.37 (2), p.148-152 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 152 |
|---|---|
| container_issue | 2 |
| container_start_page | 148 |
| container_title | Canadian Journal of Surgery |
| container_volume | 37 |
| creator | Hsiang, Y N Crespo, M T Machan, L S Bower, R D Todd, M E |
| description | To determine the feasibility of treating atherosclerotic stenoses with photodynamic therapy (PDT).
A prospective study with a 4-week follow-up.
Twelve Yucatan miniswine, weighing between 25 and 35 kg.
Aortoiliac atherosclerosis was created by a combination of balloon endothelial injury and dietary supplementation with 2% cholesterol and 15% lard for 7 weeks. Then the miniswine were given a porphyrin-type photosensitizer (Photofrin), 2.5 mg/kg intravenously, and treated with 630 nm light through an intravascular, cylindrical, diffusing fibreoptic probe, which was coupled to an argon-pumped dye laser to supply 120 J of laser energy.
Differences in luminal narrowing before and after PDT.
Seven miniswine had an increase in luminal diameter, but five had no increase. Microscopy demonstrated a broad range of features in treated vessels, including areas with re-endothelialization and regions of platelet and blood cell adherence with absent or abnormal endothelium.
Although this study demonstrated resolution in stenoses for some miniswine, questions concerning light dosimetry, mechanism of action and long-term effects remain to be determined. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_76433672</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76433672</sourcerecordid><originalsourceid>FETCH-LOGICAL-p233t-5cc8fe42ee0aaadbe8e495e35b97fe8529433a787998a2fa6d224bc808179dd13</originalsourceid><addsrcrecordid>eNpdkE1LxDAQhoMo67r6E4TiwVshX22SoyyuCgt6UNBTmaZTNkub1CZF9t_bxT15meFlHh5e5owsmdQ654LRc7KklOpccv15Sa5i3FPKqJBmQRaaFaUszZJs3nYhhebgoXc2SzscYThkbRgzOIYQbTfPNN9iQh8ixsz57GuykMBnvfMu_jiP1-SihS7izWmvyMfm8X39nG9fn17WD9t84EKkvLBWtyg5IgWApkaN0hQoitqoFnXBjRQClFbGaOAtlA3nsraaaqZM0zCxIvd_3mEM3xPGVPUuWuw68BimWKlyFpSKz-DdP3AfptHP3SpmClNQxY-22xM01T021TC6HsZDdfqO-AUyGWJm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>195950721</pqid></control><display><type>article</type><title>Photodynamic therapy for atherosclerotic stenoses in Yucatan miniswine</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Hsiang, Y N ; Crespo, M T ; Machan, L S ; Bower, R D ; Todd, M E</creator><creatorcontrib>Hsiang, Y N ; Crespo, M T ; Machan, L S ; Bower, R D ; Todd, M E</creatorcontrib><description>To determine the feasibility of treating atherosclerotic stenoses with photodynamic therapy (PDT).
A prospective study with a 4-week follow-up.
Twelve Yucatan miniswine, weighing between 25 and 35 kg.
Aortoiliac atherosclerosis was created by a combination of balloon endothelial injury and dietary supplementation with 2% cholesterol and 15% lard for 7 weeks. Then the miniswine were given a porphyrin-type photosensitizer (Photofrin), 2.5 mg/kg intravenously, and treated with 630 nm light through an intravascular, cylindrical, diffusing fibreoptic probe, which was coupled to an argon-pumped dye laser to supply 120 J of laser energy.
Differences in luminal narrowing before and after PDT.
Seven miniswine had an increase in luminal diameter, but five had no increase. Microscopy demonstrated a broad range of features in treated vessels, including areas with re-endothelialization and regions of platelet and blood cell adherence with absent or abnormal endothelium.
Although this study demonstrated resolution in stenoses for some miniswine, questions concerning light dosimetry, mechanism of action and long-term effects remain to be determined.</description><identifier>ISSN: 0008-428X</identifier><identifier>EISSN: 1488-2310</identifier><identifier>PMID: 8156469</identifier><identifier>CODEN: CJSUAX</identifier><language>eng</language><publisher>Canada: CMA Impact, Inc</publisher><subject>Animals ; Aorta, Abdominal ; Aortic Diseases - drug therapy ; Aortic Diseases - pathology ; Arteriosclerosis - drug therapy ; Arteriosclerosis - pathology ; Dihematoporphyrin Ether - administration & dosage ; Disease Models, Animal ; Evaluation Studies as Topic ; Female ; Iliac Artery ; Laser Therapy ; Male ; Photochemotherapy - instrumentation ; Photochemotherapy - methods ; Photosensitizing Agents - administration & dosage ; Swine ; Swine, Miniature</subject><ispartof>Canadian Journal of Surgery, 1994-04, Vol.37 (2), p.148-152</ispartof><rights>Copyright Canadian Medical Association Apr 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8156469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsiang, Y N</creatorcontrib><creatorcontrib>Crespo, M T</creatorcontrib><creatorcontrib>Machan, L S</creatorcontrib><creatorcontrib>Bower, R D</creatorcontrib><creatorcontrib>Todd, M E</creatorcontrib><title>Photodynamic therapy for atherosclerotic stenoses in Yucatan miniswine</title><title>Canadian Journal of Surgery</title><addtitle>Can J Surg</addtitle><description>To determine the feasibility of treating atherosclerotic stenoses with photodynamic therapy (PDT).
A prospective study with a 4-week follow-up.
Twelve Yucatan miniswine, weighing between 25 and 35 kg.
Aortoiliac atherosclerosis was created by a combination of balloon endothelial injury and dietary supplementation with 2% cholesterol and 15% lard for 7 weeks. Then the miniswine were given a porphyrin-type photosensitizer (Photofrin), 2.5 mg/kg intravenously, and treated with 630 nm light through an intravascular, cylindrical, diffusing fibreoptic probe, which was coupled to an argon-pumped dye laser to supply 120 J of laser energy.
Differences in luminal narrowing before and after PDT.
Seven miniswine had an increase in luminal diameter, but five had no increase. Microscopy demonstrated a broad range of features in treated vessels, including areas with re-endothelialization and regions of platelet and blood cell adherence with absent or abnormal endothelium.
Although this study demonstrated resolution in stenoses for some miniswine, questions concerning light dosimetry, mechanism of action and long-term effects remain to be determined.</description><subject>Animals</subject><subject>Aorta, Abdominal</subject><subject>Aortic Diseases - drug therapy</subject><subject>Aortic Diseases - pathology</subject><subject>Arteriosclerosis - drug therapy</subject><subject>Arteriosclerosis - pathology</subject><subject>Dihematoporphyrin Ether - administration & dosage</subject><subject>Disease Models, Animal</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Iliac Artery</subject><subject>Laser Therapy</subject><subject>Male</subject><subject>Photochemotherapy - instrumentation</subject><subject>Photochemotherapy - methods</subject><subject>Photosensitizing Agents - administration & dosage</subject><subject>Swine</subject><subject>Swine, Miniature</subject><issn>0008-428X</issn><issn>1488-2310</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkE1LxDAQhoMo67r6E4TiwVshX22SoyyuCgt6UNBTmaZTNkub1CZF9t_bxT15meFlHh5e5owsmdQ654LRc7KklOpccv15Sa5i3FPKqJBmQRaaFaUszZJs3nYhhebgoXc2SzscYThkbRgzOIYQbTfPNN9iQh8ixsz57GuykMBnvfMu_jiP1-SihS7izWmvyMfm8X39nG9fn17WD9t84EKkvLBWtyg5IgWApkaN0hQoitqoFnXBjRQClFbGaOAtlA3nsraaaqZM0zCxIvd_3mEM3xPGVPUuWuw68BimWKlyFpSKz-DdP3AfptHP3SpmClNQxY-22xM01T021TC6HsZDdfqO-AUyGWJm</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>Hsiang, Y N</creator><creator>Crespo, M T</creator><creator>Machan, L S</creator><creator>Bower, R D</creator><creator>Todd, M E</creator><general>CMA Impact, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M3G</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19940401</creationdate><title>Photodynamic therapy for atherosclerotic stenoses in Yucatan miniswine</title><author>Hsiang, Y N ; Crespo, M T ; Machan, L S ; Bower, R D ; Todd, M E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p233t-5cc8fe42ee0aaadbe8e495e35b97fe8529433a787998a2fa6d224bc808179dd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Aorta, Abdominal</topic><topic>Aortic Diseases - drug therapy</topic><topic>Aortic Diseases - pathology</topic><topic>Arteriosclerosis - drug therapy</topic><topic>Arteriosclerosis - pathology</topic><topic>Dihematoporphyrin Ether - administration & dosage</topic><topic>Disease Models, Animal</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Iliac Artery</topic><topic>Laser Therapy</topic><topic>Male</topic><topic>Photochemotherapy - instrumentation</topic><topic>Photochemotherapy - methods</topic><topic>Photosensitizing Agents - administration & dosage</topic><topic>Swine</topic><topic>Swine, Miniature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsiang, Y N</creatorcontrib><creatorcontrib>Crespo, M T</creatorcontrib><creatorcontrib>Machan, L S</creatorcontrib><creatorcontrib>Bower, R D</creatorcontrib><creatorcontrib>Todd, M E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>CBCA Reference & Current Events</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Canadian Journal of Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsiang, Y N</au><au>Crespo, M T</au><au>Machan, L S</au><au>Bower, R D</au><au>Todd, M E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photodynamic therapy for atherosclerotic stenoses in Yucatan miniswine</atitle><jtitle>Canadian Journal of Surgery</jtitle><addtitle>Can J Surg</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>37</volume><issue>2</issue><spage>148</spage><epage>152</epage><pages>148-152</pages><issn>0008-428X</issn><eissn>1488-2310</eissn><coden>CJSUAX</coden><abstract>To determine the feasibility of treating atherosclerotic stenoses with photodynamic therapy (PDT).
A prospective study with a 4-week follow-up.
Twelve Yucatan miniswine, weighing between 25 and 35 kg.
Aortoiliac atherosclerosis was created by a combination of balloon endothelial injury and dietary supplementation with 2% cholesterol and 15% lard for 7 weeks. Then the miniswine were given a porphyrin-type photosensitizer (Photofrin), 2.5 mg/kg intravenously, and treated with 630 nm light through an intravascular, cylindrical, diffusing fibreoptic probe, which was coupled to an argon-pumped dye laser to supply 120 J of laser energy.
Differences in luminal narrowing before and after PDT.
Seven miniswine had an increase in luminal diameter, but five had no increase. Microscopy demonstrated a broad range of features in treated vessels, including areas with re-endothelialization and regions of platelet and blood cell adherence with absent or abnormal endothelium.
Although this study demonstrated resolution in stenoses for some miniswine, questions concerning light dosimetry, mechanism of action and long-term effects remain to be determined.</abstract><cop>Canada</cop><pub>CMA Impact, Inc</pub><pmid>8156469</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-428X |
| ispartof | Canadian Journal of Surgery, 1994-04, Vol.37 (2), p.148-152 |
| issn | 0008-428X 1488-2310 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76433672 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Aorta, Abdominal Aortic Diseases - drug therapy Aortic Diseases - pathology Arteriosclerosis - drug therapy Arteriosclerosis - pathology Dihematoporphyrin Ether - administration & dosage Disease Models, Animal Evaluation Studies as Topic Female Iliac Artery Laser Therapy Male Photochemotherapy - instrumentation Photochemotherapy - methods Photosensitizing Agents - administration & dosage Swine Swine, Miniature |
| title | Photodynamic therapy for atherosclerotic stenoses in Yucatan miniswine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T12%3A39%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Photodynamic%20therapy%20for%20atherosclerotic%20stenoses%20in%20Yucatan%20miniswine&rft.jtitle=Canadian%20Journal%20of%20Surgery&rft.au=Hsiang,%20Y%20N&rft.date=1994-04-01&rft.volume=37&rft.issue=2&rft.spage=148&rft.epage=152&rft.pages=148-152&rft.issn=0008-428X&rft.eissn=1488-2310&rft.coden=CJSUAX&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E76433672%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=195950721&rft_id=info:pmid/8156469&rfr_iscdi=true |