Chemosensitivity and Perception of Dyspnea in Patients with a History of Near-Fatal Asthma
Concern about deaths from asthma is increasing 1 – 3 . Most of the deaths are avoidable if patients are adequately treated 3 , 4 . However, adequate treatment requires clarification of the mechanisms by which fatal or near-fatal attacks develop and identification of the risk factors for these attack...
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| Veröffentlicht in: | The New England journal of medicine 1994-05, Vol.330 (19), p.1329-1334 |
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| container_title | The New England journal of medicine |
| container_volume | 330 |
| creator | Kikuchi, Yoshihiro Okabe, Shinichi Tamura, Gen Hida, Wataru Homma, Masaaki Shirato, Kunio Takishima, Tamotsu |
| description | Concern about deaths from asthma is increasing
1
–
3
. Most of the deaths are avoidable if patients are adequately treated
3
,
4
. However, adequate treatment requires clarification of the mechanisms by which fatal or near-fatal attacks develop and identification of the risk factors for these attacks.
Although there have been many epidemiologic studies of fatal or near-fatal asthma,
4
–
7
there have been few studies of the mechanisms underlying life-threatening attacks
1
. One report
8
suggested that respiratory arrest, not cardiac arrest, may be the principal cause of death during an attack. The precise mechanisms of life-threatening attacks, however, were not elucidated . . . |
| doi_str_mv | 10.1056/NEJM199405123301901 |
| format | Article |
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1
–
3
. Most of the deaths are avoidable if patients are adequately treated
3
,
4
. However, adequate treatment requires clarification of the mechanisms by which fatal or near-fatal attacks develop and identification of the risk factors for these attacks.
Although there have been many epidemiologic studies of fatal or near-fatal asthma,
4
–
7
there have been few studies of the mechanisms underlying life-threatening attacks
1
. One report
8
suggested that respiratory arrest, not cardiac arrest, may be the principal cause of death during an attack. The precise mechanisms of life-threatening attacks, however, were not elucidated . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199405123301901</identifier><identifier>PMID: 8152444</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Airway management ; Asthma ; Asthma - etiology ; Asthma - mortality ; Asthma - physiopathology ; Asthma - therapy ; Biological and medical sciences ; Carbon dioxide ; Dyspnea ; Dyspnea - physiopathology ; Female ; Humans ; Hypercapnia ; Hypercapnia - physiopathology ; Hypoxia ; Hypoxia - physiopathology ; Male ; Medical sciences ; Monitoring, Physiologic ; Occlusion ; Oxygen ; Perception ; Perception - physiology ; Pharmacology. Drug treatments ; Pressure ; Remission ; Respiration ; Respiration, Artificial ; Respiratory Function Tests ; Respiratory Insufficiency - complications ; Respiratory Mechanics ; Respiratory system ; Respiratory tract ; Risk Factors ; Variance analysis ; Ventilation ; Ventilatory behavior</subject><ispartof>The New England journal of medicine, 1994-05, Vol.330 (19), p.1329-1334</ispartof><rights>Copyright © 1994 Massachusetts Medical Society. All rights reserved.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-41cdc8e955d507ae1b0f5fe19a5f7e20dac165f44b3ae7ca44e7081103811acb3</citedby><cites>FETCH-LOGICAL-c504t-41cdc8e955d507ae1b0f5fe19a5f7e20dac165f44b3ae7ca44e7081103811acb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199405123301901$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1983813113?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2757,2758,26102,27923,27924,52381,54063,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4117351$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8152444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kikuchi, Yoshihiro</creatorcontrib><creatorcontrib>Okabe, Shinichi</creatorcontrib><creatorcontrib>Tamura, Gen</creatorcontrib><creatorcontrib>Hida, Wataru</creatorcontrib><creatorcontrib>Homma, Masaaki</creatorcontrib><creatorcontrib>Shirato, Kunio</creatorcontrib><creatorcontrib>Takishima, Tamotsu</creatorcontrib><title>Chemosensitivity and Perception of Dyspnea in Patients with a History of Near-Fatal Asthma</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Concern about deaths from asthma is increasing
1
–
3
. Most of the deaths are avoidable if patients are adequately treated
3
,
4
. However, adequate treatment requires clarification of the mechanisms by which fatal or near-fatal attacks develop and identification of the risk factors for these attacks.
Although there have been many epidemiologic studies of fatal or near-fatal asthma,
4
–
7
there have been few studies of the mechanisms underlying life-threatening attacks
1
. One report
8
suggested that respiratory arrest, not cardiac arrest, may be the principal cause of death during an attack. The precise mechanisms of life-threatening attacks, however, were not elucidated . . .</description><subject>Adult</subject><subject>Airway management</subject><subject>Asthma</subject><subject>Asthma - etiology</subject><subject>Asthma - mortality</subject><subject>Asthma - physiopathology</subject><subject>Asthma - therapy</subject><subject>Biological and medical sciences</subject><subject>Carbon dioxide</subject><subject>Dyspnea</subject><subject>Dyspnea - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypercapnia</subject><subject>Hypercapnia - physiopathology</subject><subject>Hypoxia</subject><subject>Hypoxia - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monitoring, Physiologic</subject><subject>Occlusion</subject><subject>Oxygen</subject><subject>Perception</subject><subject>Perception - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pressure</subject><subject>Remission</subject><subject>Respiration</subject><subject>Respiration, Artificial</subject><subject>Respiratory Function Tests</subject><subject>Respiratory Insufficiency - complications</subject><subject>Respiratory Mechanics</subject><subject>Respiratory system</subject><subject>Respiratory tract</subject><subject>Risk Factors</subject><subject>Variance analysis</subject><subject>Ventilation</subject><subject>Ventilatory behavior</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUFv1DAQhS0EKkvhFyAkC1AvKNQT20l8rJaWFpW2B7hwiWadidarxNnaXtD--3q1qx4QdA4zh_nmvZEeY29BfAahq9Ob82_fwRglNJRSCjACnrEZaCkLpUT1nM2EKJtC1Ua-ZK9iXIlcoMwRO2pAl0qpGfs1X9I4RfLRJffbpS1H3_E7CpbWyU2eTz3_so1rT8id53eYHPkU-R-Xlhz5pYtpCtsddUMYigtMOPCzmJYjvmYvehwivTnMY_bz4vzH_LK4vv16NT-7LqwWKhUKbGcbMlp3WtRIsBC97gkM6r6mUnRoodK9UguJVFtUimrRAAiZG9qFPGYne911mO43FFM7umhpGNDTtIltXSkpK11m8P1f4GraBJ9_a8tSGiMqaDL04X8QmCZ7SgCZKbmnbJhiDNS36-BGDNsWRLsLp_1HOPnq3UF7sxipe7w5pJH3Hw97jBaHPqC3Lj5iCqCWeifzaY-NY2w9rcYnTR8AXXqhDA</recordid><startdate>19940512</startdate><enddate>19940512</enddate><creator>Kikuchi, Yoshihiro</creator><creator>Okabe, Shinichi</creator><creator>Tamura, Gen</creator><creator>Hida, Wataru</creator><creator>Homma, Masaaki</creator><creator>Shirato, Kunio</creator><creator>Takishima, Tamotsu</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19940512</creationdate><title>Chemosensitivity and Perception of Dyspnea in Patients with a History of Near-Fatal Asthma</title><author>Kikuchi, Yoshihiro ; Okabe, Shinichi ; Tamura, Gen ; Hida, Wataru ; Homma, Masaaki ; Shirato, Kunio ; Takishima, Tamotsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-41cdc8e955d507ae1b0f5fe19a5f7e20dac165f44b3ae7ca44e7081103811acb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Airway management</topic><topic>Asthma</topic><topic>Asthma - etiology</topic><topic>Asthma - mortality</topic><topic>Asthma - physiopathology</topic><topic>Asthma - therapy</topic><topic>Biological and medical sciences</topic><topic>Carbon dioxide</topic><topic>Dyspnea</topic><topic>Dyspnea - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypercapnia</topic><topic>Hypercapnia - physiopathology</topic><topic>Hypoxia</topic><topic>Hypoxia - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monitoring, Physiologic</topic><topic>Occlusion</topic><topic>Oxygen</topic><topic>Perception</topic><topic>Perception - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pressure</topic><topic>Remission</topic><topic>Respiration</topic><topic>Respiration, Artificial</topic><topic>Respiratory Function Tests</topic><topic>Respiratory Insufficiency - complications</topic><topic>Respiratory Mechanics</topic><topic>Respiratory system</topic><topic>Respiratory tract</topic><topic>Risk Factors</topic><topic>Variance analysis</topic><topic>Ventilation</topic><topic>Ventilatory behavior</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kikuchi, Yoshihiro</creatorcontrib><creatorcontrib>Okabe, Shinichi</creatorcontrib><creatorcontrib>Tamura, Gen</creatorcontrib><creatorcontrib>Hida, Wataru</creatorcontrib><creatorcontrib>Homma, Masaaki</creatorcontrib><creatorcontrib>Shirato, Kunio</creatorcontrib><creatorcontrib>Takishima, Tamotsu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kikuchi, Yoshihiro</au><au>Okabe, Shinichi</au><au>Tamura, Gen</au><au>Hida, Wataru</au><au>Homma, Masaaki</au><au>Shirato, Kunio</au><au>Takishima, Tamotsu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemosensitivity and Perception of Dyspnea in Patients with a History of Near-Fatal Asthma</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1994-05-12</date><risdate>1994</risdate><volume>330</volume><issue>19</issue><spage>1329</spage><epage>1334</epage><pages>1329-1334</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Concern about deaths from asthma is increasing
1
–
3
. Most of the deaths are avoidable if patients are adequately treated
3
,
4
. However, adequate treatment requires clarification of the mechanisms by which fatal or near-fatal attacks develop and identification of the risk factors for these attacks.
Although there have been many epidemiologic studies of fatal or near-fatal asthma,
4
–
7
there have been few studies of the mechanisms underlying life-threatening attacks
1
. One report
8
suggested that respiratory arrest, not cardiac arrest, may be the principal cause of death during an attack. The precise mechanisms of life-threatening attacks, however, were not elucidated . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>8152444</pmid><doi>10.1056/NEJM199405123301901</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1994-05, Vol.330 (19), p.1329-1334 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adult Airway management Asthma Asthma - etiology Asthma - mortality Asthma - physiopathology Asthma - therapy Biological and medical sciences Carbon dioxide Dyspnea Dyspnea - physiopathology Female Humans Hypercapnia Hypercapnia - physiopathology Hypoxia Hypoxia - physiopathology Male Medical sciences Monitoring, Physiologic Occlusion Oxygen Perception Perception - physiology Pharmacology. Drug treatments Pressure Remission Respiration Respiration, Artificial Respiratory Function Tests Respiratory Insufficiency - complications Respiratory Mechanics Respiratory system Respiratory tract Risk Factors Variance analysis Ventilation Ventilatory behavior |
| title | Chemosensitivity and Perception of Dyspnea in Patients with a History of Near-Fatal Asthma |
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