Anti-CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rat

We investigated the effect of an anti‐CD11b monoclonal antibody (1B6c) on ischemic cell damage after transient middle cerebral artery occlusion. We divided animals into three groups: MAb 1 group (n = 5)—rats were subjected to 2 hours of transient occlusion and 1B6c (1 mg/kg) was administered intrave...

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Veröffentlicht in:	Annals of neurology 1994-04, Vol.35 (4), p.458-463
Hauptverfasser:	Chen, H., Chopp, M., Zhang, R. L., Bodzin, G., Chen, Q., Rusche, J. R., Todd III, R. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Biological and medical sciences Blood Gas Analysis Blood Pressure - physiology Brain - pathology Ischemic Attack, Transient - pathology Ischemic Attack, Transient - physiopathology Ischemic Attack, Transient - therapy Macrophage-1 Antigen - immunology Male Medical sciences Neurology Rats Rats, Wistar Vascular diseases and vascular malformations of the nervous system
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