Multiple birth resulting from ovarian stimulation for subfertility treatment

Assisted reproductive technologies (ARTs) aim to increase a woman's chances of becoming pregnant by bringing many female and male gametes into close proximity. Techniques to achieve this objective include ovarian hyperstimulation by maturation of several oocytes, intrauterine insemination (IUI)...

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Veröffentlicht in:The Lancet (British edition) 2005-05, Vol.365 (9473), p.1807-1816
Hauptverfasser: Fauser, Bart CJM, Devroey, Paul, Macklon, Nick S
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creator Fauser, Bart CJM
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description Assisted reproductive technologies (ARTs) aim to increase a woman's chances of becoming pregnant by bringing many female and male gametes into close proximity. Techniques to achieve this objective include ovarian hyperstimulation by maturation of several oocytes, intrauterine insemination (IUI) of concentrated sperm, or in-vitro fertilisation (IVF) by bringing gametes together outside the female body. The very nature of ovarian hyperstimulation—with or without IUI—enhances the risk of multiple pregnancy (eg, two or more babies). In most IVF cycles, more than one embryo is transferred, again resulting in an increased chance of multiple pregnancy. Developed societies have witnessed a large rise in prevalence of twin, triplet, and higher order multiple births, mainly resulting from ARTs. The primary aim of this Review is to increase awareness of the many implications of the present iatrogenic epidemic of multiple births. The background of ovarian hyperstimulation, trends supporting current practice, and strategies to reduce the chance of multiple pregnancy are highlighted. Published online February 4, 2005 http://image.thelancet.com/extras/04art6002web.pdf
doi_str_mv 10.1016/S0140-6736(05)66478-1
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subjects Artificial insemination
Biological and medical sciences
Births
Female
Females
Fertility
Fertilization in Vitro
General aspects
Humans
Infertility
Infertility - diagnosis
Infertility - therapy
Medical sciences
Medical treatment
Multiple births
Ovulation Induction - adverse effects
Ovulation Induction - methods
Pregnancy
Pregnancy, Multiple - statistics & numerical data
Reproductive Techniques
Reproductive technologies
title Multiple birth resulting from ovarian stimulation for subfertility treatment
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