Metabolism and pharmacokinetic studies of misoprostol

Absorption, metabolism and excretion of radiolabelled misoprostol were studied in laboratory animals and in humans. Dog and man were similar in terms of key parameters examined. Misoprostol itself was not present in plasma after its oral administration to humans. Misoprostol was rapidly converted by...

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Veröffentlicht in:	Digestive diseases and sciences 1985-11, Vol.30 (11 Suppl), p.126S-128S
Hauptverfasser:	Schoenhard, G, Oppermann, J, Kohn, F E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alprostadil - analogs & derivatives Alprostadil - metabolism Alprostadil - pharmacology Animals Biotransformation Blood Proteins - metabolism Cimetidine - pharmacology Dogs Erythrocytes - metabolism Female Half-Life Haplorhini Humans Intestinal Absorption Kinetics Liver - drug effects Liver - enzymology Male Mice Misoprostol Mixed Function Oxygenases - metabolism Protein Binding Ranitidine - pharmacology Rats Tissue Distribution
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