Hepatocyte Growth Factor Accelerates the Wound Repair of Cultured Gastric Mucosal Cells
Effects of hepatocyte growth factor (HGF) on gastric wound repair were assessed. Artificial wounds of uniform size were made by mechanical cell denudation in confluent rabbit gastric mucosal cell sheets. The changes in wound size were analyzed quantitatively. The wound repair process contained an in...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1994-03, Vol.199 (3), p.1453-1460 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Watanabe, S. Hirose, M. Wang, X.E. Maehiro, K. Murai, T. Kobayashi, O. Nagahara, A. Sato, N. |
| description | Effects of hepatocyte growth factor (HGF) on gastric wound repair were assessed. Artificial wounds of uniform size were made by mechanical cell denudation in confluent rabbit gastric mucosal cell sheets. The changes in wound size were analyzed quantitatively. The wound repair process contained an initial migration stage and a later proliferation stage. The wound was completely repaired in 36 h in controls; this repair was accelerated by HGF with the induction of cell migration followed by proliferation and was retarded by tyrosine protein kinase inhibitor genistein. HGF might play some roles in gastric ulcer healing. |
| doi_str_mv | 10.1006/bbrc.1994.1394 |
| format | Article |
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Artificial wounds of uniform size were made by mechanical cell denudation in confluent rabbit gastric mucosal cell sheets. The changes in wound size were analyzed quantitatively. The wound repair process contained an initial migration stage and a later proliferation stage. The wound was completely repaired in 36 h in controls; this repair was accelerated by HGF with the induction of cell migration followed by proliferation and was retarded by tyrosine protein kinase inhibitor genistein. HGF might play some roles in gastric ulcer healing.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1006/bbrc.1994.1394</identifier><identifier>PMID: 8147890</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Cell Division - drug effects ; Cells, Cultured ; Gastric Mucosa - cytology ; Gastric Mucosa - drug effects ; Gastric Mucosa - physiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Genistein ; Growth Inhibitors - pharmacology ; Hepatocyte Growth Factor - pharmacology ; Isoflavones - pharmacology ; Kinetics ; Male ; Medical sciences ; Other diseases. Semiology ; Rabbits ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Time Factors ; Wound Healing - drug effects</subject><ispartof>Biochemical and biophysical research communications, 1994-03, Vol.199 (3), p.1453-1460</ispartof><rights>1994 Academic Press</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-334e9f15e1729b1e1bd86e9793dc6e6adec46f424fefab4b0b69d48687034f3d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X84713945$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3992502$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8147890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watanabe, S.</creatorcontrib><creatorcontrib>Hirose, M.</creatorcontrib><creatorcontrib>Wang, X.E.</creatorcontrib><creatorcontrib>Maehiro, K.</creatorcontrib><creatorcontrib>Murai, T.</creatorcontrib><creatorcontrib>Kobayashi, O.</creatorcontrib><creatorcontrib>Nagahara, A.</creatorcontrib><creatorcontrib>Sato, N.</creatorcontrib><title>Hepatocyte Growth Factor Accelerates the Wound Repair of Cultured Gastric Mucosal Cells</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Effects of hepatocyte growth factor (HGF) on gastric wound repair were assessed. Artificial wounds of uniform size were made by mechanical cell denudation in confluent rabbit gastric mucosal cell sheets. The changes in wound size were analyzed quantitatively. The wound repair process contained an initial migration stage and a later proliferation stage. The wound was completely repaired in 36 h in controls; this repair was accelerated by HGF with the induction of cell migration followed by proliferation and was retarded by tyrosine protein kinase inhibitor genistein. HGF might play some roles in gastric ulcer healing.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Cells, Cultured</subject><subject>Gastric Mucosa - cytology</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - physiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genistein</subject><subject>Growth Inhibitors - pharmacology</subject><subject>Hepatocyte Growth Factor - pharmacology</subject><subject>Isoflavones - pharmacology</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Rabbits</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Genistein</topic><topic>Growth Inhibitors - pharmacology</topic><topic>Hepatocyte Growth Factor - pharmacology</topic><topic>Isoflavones - pharmacology</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Rabbits</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Time Factors</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watanabe, S.</creatorcontrib><creatorcontrib>Hirose, M.</creatorcontrib><creatorcontrib>Wang, X.E.</creatorcontrib><creatorcontrib>Maehiro, K.</creatorcontrib><creatorcontrib>Murai, T.</creatorcontrib><creatorcontrib>Kobayashi, O.</creatorcontrib><creatorcontrib>Nagahara, A.</creatorcontrib><creatorcontrib>Sato, N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watanabe, S.</au><au>Hirose, M.</au><au>Wang, X.E.</au><au>Maehiro, K.</au><au>Murai, T.</au><au>Kobayashi, O.</au><au>Nagahara, A.</au><au>Sato, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatocyte Growth Factor Accelerates the Wound Repair of Cultured Gastric Mucosal Cells</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1994-03-30</date><risdate>1994</risdate><volume>199</volume><issue>3</issue><spage>1453</spage><epage>1460</epage><pages>1453-1460</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>Effects of hepatocyte growth factor (HGF) on gastric wound repair were assessed. Artificial wounds of uniform size were made by mechanical cell denudation in confluent rabbit gastric mucosal cell sheets. The changes in wound size were analyzed quantitatively. The wound repair process contained an initial migration stage and a later proliferation stage. The wound was completely repaired in 36 h in controls; this repair was accelerated by HGF with the induction of cell migration followed by proliferation and was retarded by tyrosine protein kinase inhibitor genistein. HGF might play some roles in gastric ulcer healing.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8147890</pmid><doi>10.1006/bbrc.1994.1394</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1994-03, Vol.199 (3), p.1453-1460 |
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| subjects | Animals Biological and medical sciences Cell Division - drug effects Cells, Cultured Gastric Mucosa - cytology Gastric Mucosa - drug effects Gastric Mucosa - physiology Gastroenterology. Liver. Pancreas. Abdomen Genistein Growth Inhibitors - pharmacology Hepatocyte Growth Factor - pharmacology Isoflavones - pharmacology Kinetics Male Medical sciences Other diseases. Semiology Rabbits Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Time Factors Wound Healing - drug effects |
| title | Hepatocyte Growth Factor Accelerates the Wound Repair of Cultured Gastric Mucosal Cells |
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