Studies on lipid oxidation in fish phospholipid liposomes
Fish phospholipid liposomes were prepared and used as an artificial membrane system to study factors influencing lipid oxidation. The extent of lipid oxidation was indexed by measuring the amount of thiobarbituric acid reactive substances (TBARS) produced. Fe2+, Fe3+, and Cu2+ were potent prooxidant...
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| Veröffentlicht in: | Biological trace element research 1994, Vol.40 (1), p.59-70 |
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| creator | LALINI RAMANATHAN DAS, N. P QIU-TIAN LI |
| description | Fish phospholipid liposomes were prepared and used as an artificial membrane system to study factors influencing lipid oxidation. The extent of lipid oxidation was indexed by measuring the amount of thiobarbituric acid reactive substances (TBARS) produced. Fe2+, Fe3+, and Cu2+ were potent prooxidants in catalysing lipid oxidation. These metal ions induced lipid oxidation in a dose dependent manner. However, Zn2+, Ni2+, and Mn2+ did not significantly (p > 0.05) affect lipid oxidation at all the concentrations (1, 10, or 100 microM) studied. Morin, luteolin (flavonoids), butein (chalcone), tannic acid, ellagic acid (polyphenols), butylated hydroxyanisole (BHA), and butylated hydroxytoluene (BHT) (synthetic antioxidants) were potent antioxidants (producing < 50% TBARS compared to control) of Fe(2+)-catalyzed lipid oxidation. Morin, luteolin, and butein possess two hydroxyl substituents, a C4 ketone structure and a 2-3 double bond, all of which contributed to their antioxidative potential. Fe2+ caused some losses of polyunsaturated fatty acids (PUFA), whereas tannic acid protected the oxidation of several of the PUFA including C 16:1 (Palmitoleic acid), C 18:3 (Linolenic acid), C 20:4 (Arachidonic acid), C 20:5 (Eicosapentaenoic acid), and C 22:6 (Docosahexaenoic acid). |
| doi_str_mv | 10.1007/BF02916821 |
| format | Article |
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Morin, luteolin, and butein possess two hydroxyl substituents, a C4 ketone structure and a 2-3 double bond, all of which contributed to their antioxidative potential. Fe2+ caused some losses of polyunsaturated fatty acids (PUFA), whereas tannic acid protected the oxidation of several of the PUFA including C 16:1 (Palmitoleic acid), C 18:3 (Linolenic acid), C 20:4 (Arachidonic acid), C 20:5 (Eicosapentaenoic acid), and C 22:6 (Docosahexaenoic acid).</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/BF02916821</identifier><identifier>PMID: 7511921</identifier><identifier>CODEN: BTERDG</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Analytical, structural and metabolic biochemistry ; Animals ; Antioxidants - pharmacology ; Biological and medical sciences ; Copper - pharmacology ; Fatty Acids - metabolism ; Fatty Acids, Unsaturated - metabolism ; Ferric Compounds - pharmacology ; Ferrous Compounds - pharmacology ; Fishes - metabolism ; Fundamental and applied biological sciences. 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P</creatorcontrib><creatorcontrib>QIU-TIAN LI</creatorcontrib><title>Studies on lipid oxidation in fish phospholipid liposomes</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><description>Fish phospholipid liposomes were prepared and used as an artificial membrane system to study factors influencing lipid oxidation. The extent of lipid oxidation was indexed by measuring the amount of thiobarbituric acid reactive substances (TBARS) produced. Fe2+, Fe3+, and Cu2+ were potent prooxidants in catalysing lipid oxidation. These metal ions induced lipid oxidation in a dose dependent manner. However, Zn2+, Ni2+, and Mn2+ did not significantly (p > 0.05) affect lipid oxidation at all the concentrations (1, 10, or 100 microM) studied. Morin, luteolin (flavonoids), butein (chalcone), tannic acid, ellagic acid (polyphenols), butylated hydroxyanisole (BHA), and butylated hydroxytoluene (BHT) (synthetic antioxidants) were potent antioxidants (producing < 50% TBARS compared to control) of Fe(2+)-catalyzed lipid oxidation. Morin, luteolin, and butein possess two hydroxyl substituents, a C4 ketone structure and a 2-3 double bond, all of which contributed to their antioxidative potential. Fe2+ caused some losses of polyunsaturated fatty acids (PUFA), whereas tannic acid protected the oxidation of several of the PUFA including C 16:1 (Palmitoleic acid), C 18:3 (Linolenic acid), C 20:4 (Arachidonic acid), C 20:5 (Eicosapentaenoic acid), and C 22:6 (Docosahexaenoic acid).</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Copper - pharmacology</subject><subject>Fatty Acids - metabolism</subject><subject>Fatty Acids, Unsaturated - metabolism</subject><subject>Ferric Compounds - pharmacology</subject><subject>Ferrous Compounds - pharmacology</subject><subject>Fishes - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycerolipids, phospholipids</subject><subject>Lipid Metabolism</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipids</subject><subject>Liposomes - metabolism</subject><subject>Other biological molecules</subject><subject>Oxidation-Reduction</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LxDAQxYMo67p68S70IB6E6uSrSY66uCoseFDPJU1SNtI2tWlB_3sjWxRm5jG8H-_wEDrHcIMBxO39BojChST4AC0x5yoHQeAQLQEXNGdKsmN0EuMHABZE0QVaCI6xIniJ1Os4We9iFrqs8b23WfjyVo8-_b7Lah93Wb8LMe3eTjfE0Lp4io5q3UR3NusKvW8e3tZP-fbl8Xl9t80NxXjMlTAGassr6agAIwjlBhviBFjJja1EmkIwDlJJMNpIToxSRSIVs6yydIWu9rn9ED4nF8ey9dG4ptGdC1MsRcEIASYSeL0HzRBiHFxd9oNv9fBdYih_eyr_e0rwxZw6Va2zf-hcTPIvZ19Ho5t60J3x8Q-jijGuJP0B-CJuTA</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>LALINI RAMANATHAN</creator><creator>DAS, N. 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Psychology</topic><topic>Glycerolipids, phospholipids</topic><topic>Lipid Metabolism</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipids</topic><topic>Liposomes - metabolism</topic><topic>Other biological molecules</topic><topic>Oxidation-Reduction</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LALINI RAMANATHAN</creatorcontrib><creatorcontrib>DAS, N. 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P</au><au>QIU-TIAN LI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on lipid oxidation in fish phospholipid liposomes</atitle><jtitle>Biological trace element research</jtitle><addtitle>Biol Trace Elem Res</addtitle><date>1994</date><risdate>1994</risdate><volume>40</volume><issue>1</issue><spage>59</spage><epage>70</epage><pages>59-70</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><coden>BTERDG</coden><abstract>Fish phospholipid liposomes were prepared and used as an artificial membrane system to study factors influencing lipid oxidation. The extent of lipid oxidation was indexed by measuring the amount of thiobarbituric acid reactive substances (TBARS) produced. Fe2+, Fe3+, and Cu2+ were potent prooxidants in catalysing lipid oxidation. These metal ions induced lipid oxidation in a dose dependent manner. However, Zn2+, Ni2+, and Mn2+ did not significantly (p > 0.05) affect lipid oxidation at all the concentrations (1, 10, or 100 microM) studied. Morin, luteolin (flavonoids), butein (chalcone), tannic acid, ellagic acid (polyphenols), butylated hydroxyanisole (BHA), and butylated hydroxytoluene (BHT) (synthetic antioxidants) were potent antioxidants (producing < 50% TBARS compared to control) of Fe(2+)-catalyzed lipid oxidation. Morin, luteolin, and butein possess two hydroxyl substituents, a C4 ketone structure and a 2-3 double bond, all of which contributed to their antioxidative potential. Fe2+ caused some losses of polyunsaturated fatty acids (PUFA), whereas tannic acid protected the oxidation of several of the PUFA including C 16:1 (Palmitoleic acid), C 18:3 (Linolenic acid), C 20:4 (Arachidonic acid), C 20:5 (Eicosapentaenoic acid), and C 22:6 (Docosahexaenoic acid).</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>7511921</pmid><doi>10.1007/BF02916821</doi><tpages>12</tpages></addata></record> |
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| ispartof | Biological trace element research, 1994, Vol.40 (1), p.59-70 |
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| subjects | Analytical, structural and metabolic biochemistry Animals Antioxidants - pharmacology Biological and medical sciences Copper - pharmacology Fatty Acids - metabolism Fatty Acids, Unsaturated - metabolism Ferric Compounds - pharmacology Ferrous Compounds - pharmacology Fishes - metabolism Fundamental and applied biological sciences. Psychology Glycerolipids, phospholipids Lipid Metabolism Lipid Peroxidation - drug effects Lipids Liposomes - metabolism Other biological molecules Oxidation-Reduction Thiobarbituric Acid Reactive Substances - metabolism |
| title | Studies on lipid oxidation in fish phospholipid liposomes |
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