Secretion of mature mouse interleukin-2 by Saccharomyces cerevisiae: use of a general secretion vector containing promoter and leader sequences of the mating pheromone α-factor

We have constructed a general expression vector which allows the synthesis and secretion of processed gene products in Saccharomyces cerevisiae. This vector contains yeast DNA, including the promoter of the mating pheromone (α-factor), its downstream leader sequence, and the TRP5 terminator. A cDNA...

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Veröffentlicht in:	Gene 1985, Vol.37 (1), p.155-161
Hauptverfasser:	Miyajima, Atsushi, Bond, Martha W., Otsu, Keiko, Arai, Ken-ichi, Arai, Naoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Biotechnology cloning vehicle Cloning, Molecular Fundamental and applied biological sciences. Psychology Fundamental immunology Fungal Proteins - genetics Genetic Vectors glycosylation Health. Pharmaceutical industry Immunobiology Industrial applications and implications. Economical aspects Interleukin-2 - genetics Interleukin-2 - metabolism Lymphokines, interleukins ( function, expression) Mating Factor Mice Other active biomolecules Peptides - genetics Production of active biomolecules Promoter Regions, Genetic Protein Processing, Post-Translational - drug effects Protein Sorting Signals - genetics Recombinant DNA Recombinant Proteins - genetics Regulatory factors and their cellular receptors Saccharomyces cerevisiae - genetics secretion Secretory Rate - drug effects T-cell growth-factor tunicamycin Tunicamycin - pharmacology
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