In vitro DNA strand scission and inhibition of nucleic acid synthesis in L1210 leukemia cells by a new class of DNA complexers, the anthra[1,9- cd]pyrazol-6(2 H)-ones (anthrapyrazoles)

CI-937 and CI-942 belong to a new class of DNA complexes, the anthra[1,9- cd]pyrazol-6(2 H)-ones (anthrapyrazoles), and are being further developed as antitumor drugs based on their curative properties against murine solid tumour models. The biochemical effects of these agents were studied in L1210...

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Veröffentlicht in:	Biochemical pharmacology 1985-10, Vol.34 (19), p.3499-3508
Hauptverfasser:	Fry, David W., Boritzki, Theodore J., Besserer, Judith A., Jackson, Robert C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacridines - therapeutic use Amsacrine Animals Anthraquinones - metabolism Anthraquinones - therapeutic use Antineoplastic agents Biological and medical sciences Colony-Forming Units Assay DNA - biosynthesis DNA - metabolism Doxorubicin - therapeutic use General aspects Kinetics Leukemia L1210 - drug therapy Leukemia L1210 - metabolism Medical sciences Mice Mitoxantrone Nucleic Acids - biosynthesis Nucleotides - metabolism Oxygen Consumption Pharmacology. Drug treatments Pyrazoles - metabolism Pyrazoles - therapeutic use RNA - biosynthesis
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