Transfer of Olanzapine Into Breast Milk, Calculation of Infant Drug Dose, and Effect on Breast-Fed Infants

OBJECTIVE: This study characterized infant drug doses and breast-milk-to-plasma area-under-the-curve ratios for olanzapine and determined plasma concentrations and effects of this drug on breast-feeding infants. METHOD: Seven mother-infant nursing pairs were studied. Olanzapine was measured in plasm...

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Veröffentlicht in:	The American journal of psychiatry 2003-08, Vol.160 (8), p.1428-1431
Hauptverfasser:	Gardiner, Sharon J., Kristensen, Judith H., Begg, Evan J., Hackett, L. Peter, Wilson, Debbie A., Ilett, Kenneth F., Kohan, Rolland, Rampono, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antipsychotic Agents - analysis Antipsychotic Agents - blood Antipsychotic Agents - pharmacokinetics Area Under Curve Babies Benzodiazepines Biological and medical sciences Breast Feeding Breastfeeding & lactation Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Drug therapy Drug toxicity and drugs side effects treatment Female Humans Infant Male Medical sciences Milk, Human - chemistry Milk, Human - metabolism Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Pirenzepine - analogs & derivatives Pirenzepine - analysis Pirenzepine - blood Pirenzepine - pharmacokinetics Side effects
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