Acute myocardial infarction
Acute myocardial infarction is a common disease with serious consequences in mortality, morbidity, and cost to the society. Coronary atherosclerosis plays a pivotal part as the underlying substrate in many patients. In addition, a new definition of myocardial infarction has recently been introduced...
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| Veröffentlicht in: | The Lancet (British edition) 2003-03, Vol.361 (9360), p.847-858 |
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| container_title | The Lancet (British edition) |
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| creator | Boersma, Eric Mercado, Nestor Poldermans, Don Gardien, Martin Vos, Jeroen Simoons, Maarten L |
| description | Acute myocardial infarction is a common disease with serious consequences in mortality, morbidity, and cost to the society. Coronary atherosclerosis plays a pivotal part as the underlying substrate in many patients. In addition, a new definition of myocardial infarction has recently been introduced that has major implications from the epidemiological, societal, and patient points of view. The advent of coronary-care units and the results of randomised clinical trials on reperfusion therapy, lytic or percutaneous coronary intervention, and chronic medical treatment with various pharmacological agents have substantially changed the therapeutic approach, decreased in-hospital mortality, and improved the long-term outlook in survivors of the acute phase. New treatments will continue to emerge, but the greatest challenge will be to effectively implement preventive actions in all high-risk individuals and to expand delivery of acute treatment in a timely fashion for all eligible patients. |
| doi_str_mv | 10.1016/S0140-6736(03)12712-2 |
| format | Article |
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Coronary atherosclerosis plays a pivotal part as the underlying substrate in many patients. In addition, a new definition of myocardial infarction has recently been introduced that has major implications from the epidemiological, societal, and patient points of view. The advent of coronary-care units and the results of randomised clinical trials on reperfusion therapy, lytic or percutaneous coronary intervention, and chronic medical treatment with various pharmacological agents have substantially changed the therapeutic approach, decreased in-hospital mortality, and improved the long-term outlook in survivors of the acute phase. New treatments will continue to emerge, but the greatest challenge will be to effectively implement preventive actions in all high-risk individuals and to expand delivery of acute treatment in a timely fashion for all eligible patients.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(03)12712-2</identifier><identifier>PMID: 12642064</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Acute coronary syndromes ; Angioplasty ; Angioplasty, Balloon, Coronary ; Arteriosclerosis ; Aspirin ; Atherosclerosis ; Biological and medical sciences ; Blood pressure ; Cardiology. Vascular system ; Cardiovascular disease ; Catheters ; Cholesterol ; Chronic illnesses ; Clinical trials ; Clinical Trials as Topic ; Conflicts of interest ; Coronary Artery Bypass ; Coronary heart disease ; Coronary vessels ; Cytokines ; Epidemiology ; Fibrinolytic Agents - therapeutic use ; Gangrene ; Growth factors ; Health risk assessment ; Heart ; Heart attacks ; Homocysteine ; Humans ; Hypertension ; Low density lipoprotein ; Medical instruments ; Medical prognosis ; Medical research ; Medical sciences ; Medical treatment ; Meta-analysis ; Meta-Analysis as Topic ; Morbidity ; Mortality ; Myocardial infarction ; Myocardial Infarction - diagnosis ; Myocardial Infarction - mortality ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; Patients ; Pharmacology ; Preventive medicine ; Proteins ; Reperfusion ; Statins ; Streptokinase - therapeutic use ; Stroke ; Substrates ; Tissue Plasminogen Activator - therapeutic use ; Treatment Outcome ; Ultrasonic imaging</subject><ispartof>The Lancet (British edition), 2003-03, Vol.361 (9360), p.847-858</ispartof><rights>2003 Elsevier Ltd</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Mar 8, 2003</rights><rights>Copyright Elsevier Limited Mar 8, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-f566b6ac6636ff8ba0aa5523c8f15d78acd3aeb9a2a0272994c960aaa986611d3</citedby><cites>FETCH-LOGICAL-c530t-f566b6ac6636ff8ba0aa5523c8f15d78acd3aeb9a2a0272994c960aaa986611d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673603127122$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14563939$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12642064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boersma, Eric</creatorcontrib><creatorcontrib>Mercado, Nestor</creatorcontrib><creatorcontrib>Poldermans, Don</creatorcontrib><creatorcontrib>Gardien, Martin</creatorcontrib><creatorcontrib>Vos, Jeroen</creatorcontrib><creatorcontrib>Simoons, Maarten L</creatorcontrib><title>Acute myocardial infarction</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Acute myocardial infarction is a common disease with serious consequences in mortality, morbidity, and cost to the society. Coronary atherosclerosis plays a pivotal part as the underlying substrate in many patients. In addition, a new definition of myocardial infarction has recently been introduced that has major implications from the epidemiological, societal, and patient points of view. The advent of coronary-care units and the results of randomised clinical trials on reperfusion therapy, lytic or percutaneous coronary intervention, and chronic medical treatment with various pharmacological agents have substantially changed the therapeutic approach, decreased in-hospital mortality, and improved the long-term outlook in survivors of the acute phase. New treatments will continue to emerge, but the greatest challenge will be to effectively implement preventive actions in all high-risk individuals and to expand delivery of acute treatment in a timely fashion for all eligible patients.</description><subject>Acute coronary syndromes</subject><subject>Angioplasty</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Arteriosclerosis</subject><subject>Aspirin</subject><subject>Atherosclerosis</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Catheters</subject><subject>Cholesterol</subject><subject>Chronic illnesses</subject><subject>Clinical trials</subject><subject>Clinical Trials as Topic</subject><subject>Conflicts of interest</subject><subject>Coronary Artery Bypass</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Cytokines</subject><subject>Epidemiology</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>Gangrene</subject><subject>Growth factors</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Homocysteine</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Low density lipoprotein</subject><subject>Medical instruments</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Meta-analysis</subject><subject>Meta-Analysis as Topic</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - mortality</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - therapy</subject><subject>Patients</subject><subject>Pharmacology</subject><subject>Preventive medicine</subject><subject>Proteins</subject><subject>Reperfusion</subject><subject>Statins</subject><subject>Streptokinase - therapeutic use</subject><subject>Stroke</subject><subject>Substrates</subject><subject>Tissue Plasminogen Activator - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Ultrasonic imaging</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0UtrFEEQB_BGDO5m9ROIEgy-DqPVr-rpk4TFqLDgQQVvTW1PD3SYnYndM4H99ul9kEBAPfXlV9VV9WfsBYcPHDh-_AFcQYVG4juQ77kwXFTiEZtzZVSllfn9mM3vyIyd5nwFAApBP2EzLlAJQDVnzy_8NIazzXbwlJpI3VnsW0p-jEP_lJ201OXw7Pgu2K_Lzz-XX6vV9y_flherymsJY9VqxDWSR5TYtvWagEhrIX3dct2YmnwjKawtCQJhhLXKWyyGbI3IeSMX7O2h73Ua_kwhj24Tsw9dR30YpuwMKm5MDbbIN_-WknNT9irw_AG8GqbUly1c2buMoGqsi3r1N8WtBSlQ7_7UB-TTkHMKrbtOcUNp6zi4XRRuH4Xb3dmBdPsonCh1L4_Np_UmNPdVx9sX8PoIKHvq2kS9j_neKY3Syt0Anw4ulAxuYkgu-xh6H5qYgh9dM8T_jHILL7Chgg</recordid><startdate>20030308</startdate><enddate>20030308</enddate><creator>Boersma, Eric</creator><creator>Mercado, Nestor</creator><creator>Poldermans, Don</creator><creator>Gardien, Martin</creator><creator>Vos, Jeroen</creator><creator>Simoons, Maarten L</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20030308</creationdate><title>Acute myocardial infarction</title><author>Boersma, Eric ; 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Coronary atherosclerosis plays a pivotal part as the underlying substrate in many patients. In addition, a new definition of myocardial infarction has recently been introduced that has major implications from the epidemiological, societal, and patient points of view. The advent of coronary-care units and the results of randomised clinical trials on reperfusion therapy, lytic or percutaneous coronary intervention, and chronic medical treatment with various pharmacological agents have substantially changed the therapeutic approach, decreased in-hospital mortality, and improved the long-term outlook in survivors of the acute phase. New treatments will continue to emerge, but the greatest challenge will be to effectively implement preventive actions in all high-risk individuals and to expand delivery of acute treatment in a timely fashion for all eligible patients.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>12642064</pmid><doi>10.1016/S0140-6736(03)12712-2</doi><tpages>12</tpages></addata></record> |
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| ispartof | The Lancet (British edition), 2003-03, Vol.361 (9360), p.847-858 |
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| language | eng |
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| subjects | Acute coronary syndromes Angioplasty Angioplasty, Balloon, Coronary Arteriosclerosis Aspirin Atherosclerosis Biological and medical sciences Blood pressure Cardiology. Vascular system Cardiovascular disease Catheters Cholesterol Chronic illnesses Clinical trials Clinical Trials as Topic Conflicts of interest Coronary Artery Bypass Coronary heart disease Coronary vessels Cytokines Epidemiology Fibrinolytic Agents - therapeutic use Gangrene Growth factors Health risk assessment Heart Heart attacks Homocysteine Humans Hypertension Low density lipoprotein Medical instruments Medical prognosis Medical research Medical sciences Medical treatment Meta-analysis Meta-Analysis as Topic Morbidity Mortality Myocardial infarction Myocardial Infarction - diagnosis Myocardial Infarction - mortality Myocardial Infarction - physiopathology Myocardial Infarction - therapy Patients Pharmacology Preventive medicine Proteins Reperfusion Statins Streptokinase - therapeutic use Stroke Substrates Tissue Plasminogen Activator - therapeutic use Treatment Outcome Ultrasonic imaging |
| title | Acute myocardial infarction |
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