Nitrous Oxide Degradation by Cobalamin-Dependent Methionine Synthase: Characterization of the Reactants and Products in the Inactivation Reaction

Cobalamin-dependent methionine synthase catalyzes the remethylation of homocysteine to form methionine, using methyltetrahydrofolate as the primary methyl donor. The enzyme is susceptible to inactivation by the anaesthetic gas, nitrous oxide, through either short-term exposure to high levels or chro...

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