Voltage Dependence of Cardiac Delayed Rectifier Block by Methanesulfonamide Class III Antiarrhythmic Agents

SUMMARYVoltage-clamp experiments were performed on isolated guinea pig ventricular myocytes to examine the voltage dependence of delayed rectifier block by methanesulfonamide channel blockers. Voltage-dependent channel block, in which block decreases as membrane potential is made more positive, coul...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1994-01, Vol.23 (1), p.37-41
Hauptverfasser:	Krafte, Douglas S, Volberg, Walter A
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Anti-Arrhythmia Agents - pharmacology Dose-Response Relationship, Drug Electrophysiology Guinea Pigs Heart Ventricles - cytology Heart Ventricles - drug effects In Vitro Techniques Phenethylamines - pharmacology Piperidines - pharmacology Procainamide - analogs & derivatives Procainamide - pharmacology Pyridines - pharmacology Sotalol - pharmacology Stereoisomerism Sulfonamides - pharmacology Ventricular Function
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