Differential expression of the beta-adrenergic receptor modifies agonist stimulation of adenylyl cyclase: a quantitative evaluation

The effect of varying levels of beta 2-adrenergic receptor (beta AR) expression on the capacity of the receptor to activate adenylyl cyclase through regulatory G proteins has been systematically explored in this paper, using differential expression of hamster and human beta AR in L cells. Equations...

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Veröffentlicht in:	Molecular pharmacology 1994-03, Vol.45 (3), p.481-489
Hauptverfasser:	WHALEY, B. S, NANYONG YUAN, BIRNBAUMER, L, CLARK, R. B, BARBER, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - drug effects Adenylyl Cyclases - metabolism Animals Biological and medical sciences Cell receptors Cell structures and functions Cricetinae Enzyme Activation Epinephrine - pharmacology Fundamental and applied biological sciences. Psychology Humans Kinetics L Cells (Cell Line) Mice Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Receptors, Adrenergic, beta - genetics Receptors, Adrenergic, beta - metabolism
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